 | Macaulay Culkin als Richard Tyler |
 | Christopher Lloyd als Mr. Dewey |
 | Whoopi Goldberg als Fantasy (voice) |
 | Patrick Stewart als Adventure (voice) |
 | Frank Welker als Horror (voice) |
 | Leonard Nimoy als Dr. Jekyll / Mr. Hyde (voice) |
 | Ed Begley Jr. als Alan Tyler |
 | Mel Harris als Claire Tyler |
 | B.J. Ward als Queen of Hearts (voice) |
 | George Hearn als Captain Ahab (voice) |
 | Ed Gilbert als George Merry (voice) |
 | Phil Hartman als Tom Morgan (voice) |
 | Jim Cummings als Long John Silver (voice) |
 | Dorian Harewood als Jamaican Pirates (voice) |
 | Robert Picardo als Pirate (voice) |
 | Richard Erdman als Pirate (voice) |
 | Fernando Escandon als Pirate (voice) |
| Canan J. Howell als Neighborhood Kid |
| Alexis Kirschner als Neighborhood Kid |
| Jessica Kirschner als Neighborhood Kid |
| Guy Mansker als Neighborhood Kid |
| Brandon S. McKay als Neighborhood Kid |
| Pixote Hunt | Director |
| David Kirschner | Story |
| David Casci | Story |
| Ernie Contreras | Screenplay |
| Joe Johnston | Director |
| Al Holter | Special Effects |
| Pat Sito | Animation Manager |
| John Huey | Special Effects |
| Craig R. Maras | Animation Manager |
| Micki Zurcher | Animation Manager |
| Brice Mallier | Special Effects |
| Eddie Rosas | Color Designer |
| Brendan Harris | Animation Manager |
| Derek L'Estrange | Animation |
| Penelope Sevier | Animation Manager |
| Dave Kupczyk | Animation |
| James Horner | Original Music Composer |
| Alexander Gruszynski | Director of Photography |
| Dan Molina | Editor |
| Amy Kimmelman | Casting |
| Pixote Hunt | Art Direction |
| David Casci | Screenplay |
| David Kirschner | Screenplay |
| Paul Gertz | Producer |
| Claire A. Glidden | Associate Producer |
| Michael R. Joyce | Producer |
| David Kirschner | Producer |
| David J. Steinberg | Co-Producer |
| Roxy Steven | Associate Producer |
| Barry Weiss | Co-Producer |
| Gordon Hunt | Casting Director |
| Kris Zimmerman | Casting Director |
