 | Sandra Bullock als Margaret Tate |
 | Ryan Reynolds als Andrew Paxton |
 | Malin Åkerman als Gertrude |
 | Craig T. Nelson als Joe Paxton |
 | Mary Steenburgen als Grace Paxton |
 | Betty White als Grandma Annie |
 | Denis O'Hare als Mr. Gilbertson |
 | Oscar Nunez als Ramone |
 | Aasif Mandvi als Bob Spaulding |
 | Michael Nouri als Chairman Bergen |
 | Gregg Edelman als Lead Counsel Malloy |
 | Michael Mosley als Chuck |
 | Dale Place als Jim McKittrick |
 | Alicia Hunt als Coffee Barista |
 | Alexis Garcia als Immigration Clerk |
 | Kortney Adams als Colden Books Receptionist |
| Chris Whitney als Medivac Pilot |
| Jerrell Lee Wesley als Jordan |
 | Phyllis Kay als Mrs. McKittrick |
 | Kate Lacey als Party Guest |
| Gene Fleming als Store Owner |
 | Mary Linda Rapelye als Executive Secretary |
 | Anne Fletcher als Jill |
| B. Johnson als Guy in Office |
 | John Franchi als Taxicab Driver (uncredited) |
 | Keith Fluker als Businessman (uncredited) |
| Dan Griffin als Businessman / Pedestrian on Sidewalk (uncredited) |
| London Hall als Wedding and Reception Guest (uncredited) |
 | Dan Marshall als Lawyer at Publishing Company (uncredited) |
 | Ron Murphy als Wedding Guest (uncredited) |
 | Niecy Nash Betts als Stewardess (uncredited) |
| Thomas Olson als Party Guest (uncredited) |
| Donna Glee Reim als Reception Guest (uncredited) |
 | Rich Skinner als New York Cab Driver (uncredited) |
| Ylian Alfaro Snyder als Immigrant at INS Office (uncredited) |
 | Uzimann als Pedestrian (uncredited) |
 | Larry Vigus als Party Guest (uncredited) |
| Anne Fletcher | Director |
| Pete Chiarelli | Writer |
| Catherine Marie Thomas | Costume Design |
| David Hoberman | Producer |
| Todd Lieberman | Producer |
| Buck Damon | Music Supervisor |
| Melissa Muik | Music Editor |
| Zachary Woodlee | Associate Choreographer |
| Aaron Zigman | Original Music Composer |
| Susanna David | Script Supervisor |
| Priscilla Nedd-Friendly | Editor |
| Oliver Stapleton | Director of Photography |
| Nelson Coates | Production Design |
| Denise Pizzini | Set Decoration |
| Ann Masterson | Makeup Department Head |
| Roberto Orci | Executive Producer |
| Alex Kurtzman | Executive Producer |
| Sandra Bullock | Executive Producer |
| Mary McLaglen | Executive Producer |
| Mary McLaglen | Unit Production Manager |
| Mike Massa | Stunt Coordinator |
| Scott Meehan | Art Direction |
| Jodi Baldwin | Costume Supervisor |
| Morgan Gjovik | Assistant Editor |
| Mateo Laboriel | Music Programmer |
| Amanda Mackey | Casting |
| Cathy Sandrich Gelfond | Casting |
| Raymond Prado | Second Unit Director |
| Rich Sickler | First Assistant Director |
| Rosemary C. Cremona | Second Assistant Director |
| Mark Vanselow | Stunt Double |
| Zoë Bell | Stunt Double |
| Adam McCarthy | Production Supervisor |
| David Utley | Assistant Art Director |
| Mickey Carleton | Assistant Costume Designer |
| Pamela S. Westmore | Makeup Artist |
| Tricia Heine | Makeup Artist |
| Medusah | Hair Department Head |
| Janine Rath-Thompson | Hairstylist |
| Elizabeth Cecchini | Hairstylist |
| Karen Baker Landers | Supervising Sound Editor |
| Jon Taylor | Sound Re-Recording Mixer |
| Christian P. Minkler | Sound Re-Recording Mixer |
| Christopher Assells | Sound Effects Editor |
| Dan Hegeman | Sound Effects Editor |
| Peter Staubli | Sound Effects Editor |
| Mollie Stallman | Second Second Assistant Director |
| Gina B. Cranham | Set Designer |
| Daren Janes | Set Designer |
| Brian Drewes | Visual Effects Producer |
| Geoff McAuliffe | Visual Effects Supervisor |
| Sean Devereaux | Visual Effects Supervisor |
| J.C. Robaina | Stunts |
| Michael T. Brady | Stunts |
