 | Louis Jourdan als Dr. Anton Arcane |
 | Heather Locklear als Abby Arcane |
 | Sarah Douglas als Dr. Lana Zurrell |
 | Dick Durock als Swamp Thing |
 | Joey Sagal als Gunn |
 | Ace Mask als Dr. Rochelle |
 | Monique Gabrielle als Miss Poinsettia |
 | RonReaco Lee als Omar |
 | Daniel Emery Taylor als Darryl Hallenbeck |
| Ralph Pace als Sheriff Beaumont |
 | Alex Van als Gurdell |
| Christopher Doyle als Leechman |
| Rex Pierson als Dr. Rochelle Mutation |
 | Tony Sears als Harry Dugan |
 | Bill Eudaly als Withered Chuck |
| Anthony Cecere als Conkilin |
| Timothy Birch als Clyde |
| J. Don Ferguson als Bob |
 | Jim Grimshaw als Morty |
| Albert B. Cooper IV als Taxi Driver |
| Jim Wynorski | Director |
| Neil Cuthbert | Writer |
| Michael Uslan | Producer |
| Grant Morris | Writer |
| Benjamin Melniker | Producer |
| Vicki Graef | Costume Design |
| Peter Tomaszewicz | Sound Effects Editor |
| Zoran Hochstätter | Director of Photography |
| Frank Galline | Set Decoration |
| Robert Fitzgerald | Supervising Sound Editor |
| Fred Wasser | Sound Effects Editor |
| Chuck Cirino | Original Music Composer |
| Jim Bryan | Sound Effects Editor |
| Frank Welker | Special Sound Effects |
| Linda Moss | Dialogue Editor |
| Robb Wilson King | Production Design |
| Anthony Cecere | Stunt Coordinator |
| Leslie Rosenthal | Editor |
| Bob Shelley | Special Effects Coordinator |
| Lorraine Watson | Hairstylist |
| Michael R. Jones | Special Effects Makeup Artist |
| Annette Cirillo | Co-Producer |
| Robert E. Warner | Associate Producer |
| Charles Mitchell | Executive Producer |
| Gene Witham | Makeup Artist |
| Tom Kuhn | Executive Producer |
| Coree Lear | Makeup Artist |
| Len Wein | Comic Book |
| Bernie Wrightson | Comic Book |
| Linda Kaye | Stunts |
| Steve Neill | Special Effects Makeup Artist |
