 | Anthony Hopkins als Father Lucas Trevant |
 | Colin O'Donoghue als Michael Kovak |
 | Alice Braga als Angeline |
 | Rutger Hauer als Istvan Kovak |
 | Ciarán Hinds als Father Xavier |
 | Toby Jones als Father Matthew |
 | Maria Grazia Cucinotta als Aunt Andria |
 | Marta Gastini als Rosaria |
 | Arianna Veronesi als Francesca |
 | Andrea Calligari als Vincenzo |
 | Christopher Marquette als Eddie |
 | Torrey DeVitto als Nina |
| Ben Cheetham als Young Michael |
 | Marija Karan als Sandra |
 | Rosa Pianeta als Woman in Exorcism Video |
 | Giampiero Ingrassia als Doctor |
| Rosario Tedesco als Police Officer |
 | Cecilia Dazzi als Nurse |
| Attila Bardóczy als Xavier's Secretary |
 | Nadia Kibout als Ethnic Nun |
 | Anita Pititto als Vatican Nun |
| Sandor Baranyai als Concierge |
 | Fabiola Balestriere als Young Girl |
| Aniko Vincze als Katalin Kovak |
| Mikael Håfström | Director |
| Matt Baglio | Novel |
| Robert Bernacchi | Executive Producer |
| Merideth Finn | Executive Producer |
| Beau Flynn | Producer |
| Tripp Vinson | Producer |
| Alex Heffes | Original Music Composer |
| Ben Davis | Director of Photography |
| David Rosenbloom | Editor |
| Deborah Aquila | Casting |
| Tricia Wood | Casting |
| Andrew Laws | Production Design |
| Lóránt Jávor | Art Direction |
| Michael Petroni | Writer |
| Carlo Poggioli | Costume Design |
| Trefor Proud | Makeup Department Head |
| Anthony Rizzo | Animation |
| Paul Allen | Leadman |
| Caitlin McKenna | ADR Voice Casting |
| Jessica Hurles-Laws | Second Unit First Assistant Director |
| Father Gary Thomas | Consulting Producer |
| Christy Fletcher | Co-Producer |
| Emma Parry | Co-Producer |
| Richard Brener | Executive Producer |
| Robert Bernacchi | Unit Production Manager |
| Elena Zokas | Unit Production Manager |
| Sean Guest | First Assistant Director |
| Charles Croughwell | Stunt Coordinator |
| Rick LeFevour | Stunt Coordinator |
| Domonkos Párdányi | Stunt Coordinator |
| Stefano Maria Mioni | Stunt Coordinator |
| Mark Tuohy | Co-Producer |
| Mária Ungor | Production Manager |
| Stuart Kearns | Supervising Art Director |
| Peter Walpole | Set Decoration |
| Zoltán Horváth | Set Decoration |
| Dóra Simkó | Script Supervisor |
| Mac Ruth | Production Sound Mixer |
| Trefor Proud | Makeup Designer |
| Tracey Wells | Makeup Artist |
| Sharon Martin | Makeup Artist |
| Kristyan Mallett | Makeup Artist |
| Katalin Jakots | Makeup Artist |
| Iván Pohárnok | Prosthetic Makeup Artist |
| Serena Fiumi | Costume Supervisor |
| Anina Pinter | Assistant Costume Designer |
| Charlene Olson | Post Production Supervisor |
| Mark A. Mangini | Supervising Sound Editor |
| Dave Whitehead | Sound Designer |
| John T. Reitz | Sound Re-Recording Mixer |
| Gregg Rudloff | Sound Re-Recording Mixer |
| Rick Kline | Sound Re-Recording Mixer |
| Mike Chock | Sound Effects Editor |
| James Andrew Haven | Second Assistant Director |
| Bogi Móricz | Second Assistant Director |
| Senica Billingsley | Second Assistant Director |
| Gergo Fulop | Second Second Assistant Director |
| Linda Marián | Third Assistant Director |
| Marc Kolbe | Visual Effects Supervisor |
| John Greaves | Second Unit Director |
| Piero Mura | Sound Effects Editor |
