 | Bill Hader als Milo Dean |
 | Kristen Wiig als Maggie Dean |
 | Luke Wilson als Lance |
 | Ty Burrell als Rich |
 | Boyd Holbrook als Billy |
 | Joanna Gleason als Judy |
 | Kathleen Rose Perkins als Carlie |
 | Adriane Lenox als Dr. Linda Essex |
 | Sydney Lucas als Young Maggie |
 | Eddie Schweighardt als Young Milo |
 | Paul Castro Jr. als Eric |
 | Benjamin McGowan als Cullen |
 | Jennifer Smith als Bar Woman |
 | Genevieve Adams als Store Manager |
 | Truck Hudson als Security Officer |
 | Cliff Moylan als Police Officer |
 | Ian Hyland als Waiter (uncredited) |
 | David Garelik als College Dude (uncredited) |
 | Jennifer Lafleur als Drunk Natalie (uncredited) |
| Noah Segura als Librarian (uncredited) |
| Craig Johnson | Director |
| Mark Heyman | Writer |
| Craig Johnson | Writer |
| Reed Morano | Director of Photography |
| Nathan Larson | Original Music Composer |
| Stephanie Langhoff | Producer |
| Jennifer Lee | Producer |
| Jacob Pechenik | Producer |
| Avy Kaufman | Casting |
| Anton Gold | Sound Mixer |
| Mark Duplass | Executive Producer |
| Jared Ian Goldman | Executive Producer |
| Jennifer Lee | Editor |
| Mikaela Wohl | Costume Design |
| Lauren DeTitta | Set Decoration |
| Ola Maslik | Production Design |
| Valerie Velez | Hair Department Head |
| Leo Won | Makeup Department Head |
| Daniel Heffernan | Sound Editor |
| Matt Schoenfeld | Sound Designer |
| Reed Morano | Camera Operator |
| Joseph Ciccarella | First Assistant Director |
| Anne Marie Dentici | Second Assistant Director |
| Jay Duplass | Executive Producer |
| Tamika Jackson | Costume Supervisor |
| Ian Stynes | Sound Re-Recording Mixer |
| Ian Stynes | Sound Designer |
| Ian Stynes | Supervising Sound Editor |
| Shaun Brennan | Foley Artist |
| Clay Enos | Still Photographer |
| Roxie Rodriguez | Associate Producer |
