 | Melissa McCarthy als Lilly Maynard |
 | Chris O'Dowd als Jack Maynard |
 | Kevin Kline als Dr Larry Fine |
 | Timothy Olyphant als Travis Delp |
 | Daveed Diggs als Ben |
 | Skyler Gisondo als Dickey |
 | Laura Harrier als Sherri |
 | Rosalind Chao als Fawn |
 | Kimberly Quinn als Regina |
 | Loretta Devine als Velma |
 | Jesse Garcia als Hector |
 | Edi Patterson als Margie |
 | Emily Tremaine als Alice |
 | Ravi Kapoor als Dr Manmohan |
 | Don McManus als Big Daddy |
 | Owen Atlas als Howie |
| Matt Harris | Screenplay |
| Dylan Sellers | Producer |
| Theodore Melfi | Director |
| Zack Schiller | Executive Producer |
| Theodore Melfi | Producer |
| David Boies III | Executive Producer |
| Kimberly Quinn | Producer |
| Alex Dong | Executive Producer |
| Susie DeSanto | Costume Design |
| Stephanie Hamilton | Production Design |
| Lawrence Sher | Cinematography |
| Peter Teschner | Editor |
| Jessica Shorten | Art Direction |
| Lizzie Boyle | Set Decoration |
| Tiphanie Baum | Key Hair Stylist |
| Cindy Escalante | Key Makeup Artist |
| Kimberly Greene | Makeup Department Head |
| Kerry Mendenhall | Hair Department Head |
| Michelle Sfarzo | Makeup Artist |
| Erin Wooldridge | Key Makeup Artist |
| Matthew Nicolay | Sound Mixer |
| Taylor Flinn | Sound Effects Editor |
| Mike Horton | Foley Artist |
| Wayne Lemmer | Sound Re-Recording Mixer |
| Walter Spencer | Foley Supervisor |
| Dirk Stout | Boom Operator |
| Zev Foreman | Executive Producer |
| C.J. Barbato | Associate Producer |
| Justin Bursch | Executive In Charge Of Production |
| Nancy Kirhoffer | Post Production Producer |
| Gabby Revilla Lugo | Executive Producer |
| Mary Vernieu | Casting |
| Michelle Wade Byrd | Casting |
| Trisha Wilson | Associate Producer |
| Tyler Zacharia | Executive Producer |
| Matthew Friedman | Editor |
| Michael G. Cruz | Location Scout |
| Meegan E. Godfrey | Stunts |
| Luci Romberg | Stunt Coordinator |
| Katie Rowe | Stunts |
| Mark R. Byers | Special Effects Supervisor |
| Ken Rudell | Special Effects Supervisor |
| Steve Sosner | Special Effects Technician |
| Lycee Anaya | Compositor |
| Jon Balcome | CG Supervisor |
| Zach Hamelton | Visual Effects Coordinator |
| Spencer Hecox | Visual Effects Supervisor |
| Joshua LaCross | Visual Effects Supervisor |
| Matt Lathrom | Visual Effects Supervisor |
| Iskra Nacheva | Visual Effects Producer |
| Adam Pere | Visual Effects Producer |
| Ben Sumner | Visual Effects |
| Benjamin Wallfisch | Original Music Composer |
