 | David Duchovny als Fox Mulder |
 | Gillian Anderson als Dana Scully |
 | Amanda Peet als ASAC Dakota Whitney |
 | Billy Connolly als Father Joseph Crissman |
 | Xzibit als Agent Mosley Drummy |
 | Mitch Pileggi als Walter Skinner |
 | Callum Keith Rennie als 2nd Abductor - Janke Dacyshyn |
 | Adam Godley als Father Ybarra |
 | Alex Diakun als Gaunt Man |
 | Nicki Aycox als 2nd Victim - Cheryl Cunningham |
 | Fagin Woodcock als 1st Abductor - Franz Tomczeszyn |
| Marco Niccoli als Christian Fearon |
 | Carrie Ruscheinsky als Margaret Fearon |
 | Spencer Maybee als Blair Fearon |
 | Veronika Hadravá als Female Assistant |
| Denis Krasnogolov als Male Assistant |
 | Patrick Keating als Slight Man |
 | Stephen E. Miller als Feed Store Proprietor |
 | Xantha Radley als Monica Bannan |
 | Lorena Gale als On Screen Doctor |
 | Donavon Stinson als Suited Man |
 | Dion Johnstone als 1st Cop |
 | Sarah-Jane Redmond als Special Agent in Charge |
| Christina D'Alimonte als Doctor's Colleague |
 | Vanesa Tomasino als Hallway Agent |
 | Luvia Petersen als O.R. Nurse |
 | Babs Chula als Surgeon |
 | Marci T. House als Sheriff |
 | Joseph Patrick Finn als Whispering Priest |
| Beth Siegler als Anesthesiologist |
 | Stacee Copeland als Doctor |
| Tom Charron als Sheriff Horton |
| Brent C.S. O'Connor als Tow Truck Driver |
| Dave Cote als D-Man |
 | Chris Carter als Man sitting in hospital hallway |
| Paul Mitton als FBI Agent |
 | Vanessa Morley als Female Hallway Agent |
| Michael Stevens als Board Room Doctor |
 | Lynne Burnett als Murder Victim (uncredited) |
 | Celeste Insell als Board Room Doctor (uncredited) |
 | Teana-Marie Smith als Nurse (uncredited) |
| Roger Horchow als Elderly Gent |
| Chris Carter | Director |
| Chris Carter | Screenplay |
| Frank Spotnitz | Screenplay |
| Chris Carter | Producer |
| Mark Snow | Original Music Composer |
| Bill Roe | Director of Photography |
| Richard A. Harris | Editor |
| Heike Brandstatter | Casting |
| Mindy Marin | Casting |
| Coreen Mayrs | Casting |
| Mark S. Freeborn | Production Design |
| Tony Wohlgemuth | Art Direction |
| Shirley Inget | Set Decoration |
| Lisa Tomczeszyn | Costume Design |
| Victoria Down | Makeup Department Head |
| Sandy Monesmith | Hairstylist |
| Julio Pallares | Makeup Effects |
| Christopher Mark Pinhey | Makeup Effects |
| Bill Terezakis | Makeup Effects |
| Maureen Terezakis | Makeup Effects |
| Simon Abbott | Production Manager |
| Wayne Bennett | Production Manager |
| David McKimmie | Post-Production Manager |
| Brent O'Connor | Unit Production Manager |
| Paul Rabwin | Post Production Supervisor |
| E. J. Foerster | Second Unit |
| Jared Brown | Set Dressing Artist |
| Raul Casillas | Set Dressing Artist |
| Geoff Coulter | Set Dressing Artist |
| David Hadaway | Set Designer |
| Scott Holburn | Set Dressing Artist |
| Leonardo Lara | Set Dressing Artist |
| Cheryl Marion | Assistant Art Director |
| Mark Prior | Set Dressing Artist |
| Mike Rennison | Construction Coordinator |
| Paul Rinaldi | Construction Foreman |
| Sabine Schoppel | Art Department Coordinator |
| Jenny Seinen | Storyboard |
| David Betancourt | Foley |
| David Giammarco | Sound Re-Recording Mixer |
| David Grimaldi | Sound Effects Editor |
| Randall Guth | First Assistant Sound Editor |
| Warren Hendriks | Sound Effects Editor |
| Martin Lacroix | Boom Operator |
| David Lucarelli | ADR & Dubbing |
| Paul Massey | Sound Re-Recording Mixer |
| Chuck Michael | Sound Designer |
| Erin Michael Rettig | Sound Engineer |
| Charleen Richards-Steeves | ADR & Dubbing |
| Alicia Stevenson | Foley |
| William Unrau | Cableman |
| David Gauthier | Special Effects Coordinator |
| David Alexander | CG Supervisor |
| Rodrigo Armendariz | Compositors |
| Steve Au | CG Painter |
| Michel Barrière | Compositors |
| Mat Beck | Visual Effects Supervisor |
| Charles Collyer | Compositors |
| Glenn Curry | CG Painter |
| Anouk Deveault-Moreau | Visual Effects Supervisor |
| Linda Drake | Visual Effects Editor |
| Jason Dunn | Compositors |
| Andrew Edwards | Compositors |
| Ryan Epp | Compositors |
| Thomas F. Ford IV | Visual Effects Producer |
| Mark Goldberg | Compositors |
| Don Greenberg | Compositors |
| Junji Hirano | CG Painter |
| Graham Houston | CG Painter |
| Brenda Ilic | Visual Effects Producer |
| Joni Jacobson | Visual Effects Producer |
| Daniel Leduc | Visual Effects Producer |
| Andrew Lema | CG Painter |
| Matthias Lowry | Compositors |
| Richard Martin | Compositors |
| Jack Noriaki Matsumoto | CG Painter |
| Steve J. McLeod | Compositors |
| Vinay Mehta | Compositors |
| Tena Montoya | Visual Effects Producer |
| Eugene Paluso | CG Painter |
| Rod Park | Visual Effects Producer |
| Brian Petras | Compositors |
| Pierre Raymond | Executive Visual Effects Producer |
| Dan Rucinski | Production Supervisor |
| Brian Sales | Compositors |
| Andrea Shear | CG Painter |
| Wayne A. Shepherd | Compositors |
| Randal Shore | Visual Effects Producer |
| Trent Smith | Visual Effects Producer |
| Christina Spring | Compositors |
| Mike Spring | Compositors |
| Marty Taylor | Compositors |
| Patrick Thompson | Compositors |
| Anne Tremblay | Administration |
| Donald Tse | Compositors |
| Dmitry Vinnik | CG Painter |
| John C. Wash | Visual Effects Supervisor |
| Dave Williams | Compositors |
| Ian Wilson | CG Painter |
| Chris Atkinson | Stunts |
| James Bamford | Stunts |
| Guy Bews | Stunts |
| Kimberly Chiang | Stunts |
| Duane Dickinson | Stunts |
| Mike Dobbin | Stunts |
| Bill Edwards | Stunts |
| Corbin Fox | Stunts |
| Dean Hart | Stunts |
| Dave Lane | Stunts |
| Mike Mitchell | Stunt Coordinator |
| Tony Morelli | Stunts Coordinator |
| Jennifer Mylrea | Stunts |
| Jeff Sanca | Stunts |
| Todd Scott | Stunts |
| Melissa R. Stubbs | Stunts |
| Natasha Vasiluk | Stunts |
| Marshall Virtue | Stunts |
| Chris Webb | Stunts |
| Matt Almas | Grip |
| Ryan Bailey | Gaffer |
| Mitch Bax | Camera Intern |
| George Collins | Video Assist Operator |
| Gitte Axen | Makeup Artist |
| Brent O'Connor | Executive Producer |
| Frank Spotnitz | Producer |
| Wayne McLaughlin | Property Master |
| Marta McLaughlin | Assistant Property Master |
| Eric Partridge | Assistant Property Master |
| Brad McMurray | Set Decorating Coordinator |
| John S. Bartley | Second Unit Director of Photography |
| Cory Budney | First Assistant Camera |
| Dennis Rogers | Sound Recordist |
| Tim Gomillion | Sound Recordist |
| Portia Tickell | Script Supervisor |
| Gloria D'Alessandro | Dialogue Editor |
| Mildred Iatrou | ADR Editor |
| Scott Curtis | Foley Editor |
| Matthew Harrison | Foley Editor |
| Galen Goodpaster | Assistant Sound Editor |
| Eric A. Larsen | Assistant Sound Editor |
| Smokey Cloud | Assistant Sound Editor |
| Michael T. Williamson | Sound Mixer |
| Bryce Brecheisen | Visual Effects Coordinator |
| Shane Strickman | Visual Effects Coordinator |
| Mark Sweatman | Production Assistant |
| Charles Andre | Stunts |
