 | Danny DeVito als Owen / Ned 'Little Ned' Lift |
 | Billy Crystal als Larry Donner |
 | Kim Greist als Beth Ryan |
 | Anne Ramsey als Mrs. Lift |
 | Kate Mulgrew als Margaret |
 | Branford Marsalis als Lester |
 | Rob Reiner als Joel |
 | Bruce Kirby als DeBenedetto |
 | Annie Ross als Mrs. Hazeltine |
 | Oprah Winfrey als Herself |
 | Raye Birk als Pinsky |
 | Olivia Brown als Ms. Gladstone |
 | Joey DePinto als Sargeant |
| Philip Perlman als Mr. Perlman |
| Stu Silver als Ramon |
 | J. Alan Thomas als Millington |
 | Randall Miller als Bucky |
| Andre Rosey Brown als Rosey |
 | Tony Ciccone als Mr. Lopez |
 | Larry McCormick als Announcer |
 | Peter Brocco als Old Man |
| Hettie Lynne Hurtes als Reporter |
| Danny DeVito | Director |
| Stu Silver | Screenplay |
| Barry Sonnenfeld | Director of Photography |
| Michael Jablow | Editor |
| Larry Brezner | Producer |
| David Newman | Original Music Composer |
| Anne D. McCulley | Set Decoration |
| David B. Cohn | ADR Editor |
| Bob Newlan | Sound Editor |
| Ida Random | Production Design |
| Laurel Moore | Still Photographer |
| Fred Scialla | Camera Operator |
| C.J. Maguire | Property Master |
| Jerry Stanford | Sound Editor |
| Robert R. Rutledge | Supervising Sound Editor |
| William A. Elliott | Art Direction |
| Dorothy Byrne | Hairstylist |
| Ken Chase | Makeup Artist |
| Joseph G. Pacelli Jr. | Set Designer |
| Scott A. Hecker | Sound Editor |
| George Stokes | Construction Coordinator |
| Marilyn Vance | Costume Design |
| Vince Deadrick Sr. | Stunt Coordinator |
| Robert Waxman | Sound Editor |
| Allegra Clegg | Production Coordinator |
| M. Todd Henry | Camera Operator |
| Michele Neely | Costume Supervisor |
| Esther Vivante | Script Supervisor |
| R. Gilbert Clayton | Set Designer |
| John Frazier | Special Effects Coordinator |
| Dana Dru Evenson | Stunts |
| Marguerite Happy | Stunts |
| Richard Drown | Stunts |
| Larry Holt | Stunts |
| Donna Garrett | Stunts |
| Vince Deadrick Jr. | Stunts |
| Orwin C. Harvey | Stunts |
| Joe Napolitano | First Assistant Director |
| Patricia Highsmith | Original Film Writer |
