 | Tim Heidecker als Tim Heidecker |
 | Eric Wareheim als Eric Wareheim |
 | John C. Reilly als Taquito |
 | Zach Galifianakis als Jim Joe Kelly |
 | Will Ferrell als Damien Weebs |
 | Robert Loggia als Tommy Schlaaang |
 | Ray Wise als Dr. Doone Struts |
 | Jeff Goldblum als Chef Goldblum |
 | Bob Odenkirk als Schlaaang Announcer |
 | William Atherton als Earle Swinter |
 | Noah Spencer als Jeffery |
| Jon Baggio als Jason |
| Gabriel Bartalos als Wolf Puppeteer |
 | Nancy Stelle als Woman on Paris Street |
 | Ronnie Rodriguez als Diamond Jim / Johnny Depp |
 | Marilyn Porayko als Women Being Ticketed |
 | Andy Spencer als Studio Executive 2 |
 | Michael Gross als Narrator |
 | Will Forte als Allan Bishopman |
 | James Quall als Self |
| David Liebe Hart als Self |
 | Dita de Leon als Cocaine Girl (uncredited) |
 | Bill A. Jones als Serious Announcer |
| Frank Slaten als Super Seat Customer |
| Bob Ross als Self |
 | Jean-Michel Richaud als Paris Policeman |
 | Kristopher Logan als Studio Executive 1 |
| Christopher Guckenberger als Studio Executive 3 |
| John Downey III als Cornell |
| Mary Bly als Mrs. Heidecker |
 | Lillian Adams als Mrs. Wareheim |
| Jay Mawhinney als Bartender |
| Loki als Tattoo Artist |
| Harry Elmayan als Delivery Man |
 | Tennessee Luke als Self |
 | Robert Axelrod als Self |
| Ted Neubauer als Man on Street |
| Dena Roe als Woman on Street |
 | Twink Caplan als Katie |
 | Kimberly Ables Jindra als Woman Giving Birth |
| Kirk Diedrich als Roy |
| Doug Foster als Customer |
 | Matt O'Toole als Reggie |
 | Rae Sunshine Lee als Shrim God 1 |
| Palmer Scott als Shrim God 2 |
| Mobin Khan als El Hat Propietor |
| Cole Carl Mangham als Shrim Kid #1 |
| Zachariah James-Jadon Evans als Shrim Kid #2 |
| Frunzik Ayvazyan Jr. als Shrim Kid #3 |
| Joshua Briscoe als Shrim Kid #4 |
 | Todd Wagner als Hobo |
| Howie Slater als Steven Spielberg |
| Eric Wareheim | Director |
| Tim Heidecker | Screenplay |
| Jonathan Krisel | Additional Writing |
| Doug Lussenhop | Additional Writing |
| Jon Mugar | Additional Writing |
| Eric Wareheim | Screenplay |
| Melanie Mandl | Art Direction |
| Eric Wareheim | Producer |
| Todd Wagner | Producer |
| Tim Heidecker | Director |
| Doug Lussenhop | Editor |
| Daniel Haworth | Editor |
| Mark Cuban | Executive Producer |
| Tim Heidecker | Songs |
| Tim Heidecker | Producer |
| Davin Wood | Music |
| James Levine | Casting Director |
| Susan Deming | Casting Director |
| Clark Reinking | Casting Director |
| Rosie Sanders | Production Design |
| Sean Michael Smith | Art Direction |
| Sarah Staskauskas | Set Decoration |
| Dean Styers | Set Decoration |
| Diana Contreras | Costume Design |
| Gabriel Bartalos | Makeup Effects |
| Mae Hess | Hairstylist |
| Heather O'Boyle | Hairstylist |
| Nancie Rooney | Hair Department Head |
| Jennifer Zide | Key Makeup Artist |
| Caroline Bader | Production Supervisor |
| Charles V. Bender | Post-Production Manager |
| Wendy Kutzner | Production Manager |
| Nicolas Harvard | First Assistant Director |
| Julie McCoy | Second Second Assistant Director |
| Rico Savage | Second Assistant Director |
| Dan Dorfer | Painter |
| Craig Handschu | Leadman |
| Colin Morris | Art Department Assistant |
| Drew T. Pierce | Storyboard Artist |
| Derek G. Riley | Property Master |
| Marissa Stone | Art Department Assistant |
| Ray Vanatta | Leadman |
| Jesse D. Vogel | Set Painter |
| Ryan Watson | Art Department Assistant |
| Diane Zurn | Set Dresser |
| Steve Arcabascio | Utility Sound |
| Steven Avila | Supervising Sound Effects Editor |
| Tara Blume | Foley Artist |
| Trip Brock | Supervising Sound Editor |
| Shaun Cunningham | Foley Mixer |
| Lorita de la Cerna | Foley Artist |
| Rob Embrey | Sound Post Production Coordinator |
| Peter D. Lago | Sound Effects Editor |
| Greg Mauer | Foley Mixer |
| Fernando Muga | Boom Operator |
| Owen Peterson | Sound Recordist |
| Alexander Pugh | Sound Effects Editor |
| Mark A. Rozett | Sound Re-Recording Mixer |
| Ian Shedd | Assistant Sound Editor |
| Steven Utt | Sound Recordist |
| Kelly Vandever | Sound Re-Recording Mixer |
| Russell White | Sound Mixer |
| Ben Whitver | ADR Mixer |
| Ben Whitver | Dialogue Editor |
| Wayne Beauchamp | Special Effects Coordinator |
| Robert Dahlin | Visual Effects Supervisor |
| Graham Herbster | Matchmove Supervisor |
| Eric Notarnicola | Visual Effects |
| Thomas DeWier | Stunt Coordinator |
| Brett A. Jones | Stunt Double |
| Stephen W. Schriver | Stunt Double |
| Eli Berg | Second Assistant Camera |
| Jason Porter | Title Designer |
| Lyal Holmberg | Location Manager |
| Davin Wood | Music Supervisor |
| Michael Giambra | Thanks |
| Daniel Gray Longino | Thanks |
| Matthew Gowan | Art Department Production Assistant |
| Rachel Morrison | Director of Photography |
| Rachel Morrison | Camera Operator |
| Jackie Johnson | Dialogue Editor |
