 | Kyrie Irving als Uncle Drew |
 | Lil Rel Howery als Dax Winslow |
 | Shaquille O'Neal als Big Fella |
 | Chris Webber als Preacher |
 | Reggie Miller als Lights |
 | Nate Robinson als Boots |
 | Lisa Leslie als Betty Lou |
 | Erica Ash als Maya |
 | J.B. Smoove als Angelo |
 | Mike Epps als Louis |
 | Tiffany Haddish als Jess |
 | Nick Kroll als Mookie Bass |
 | Ashton Tyler als Young Dax |
 | Aaron Gordon als Casper Jones |
 | Wesley Witherspoon als Mario |
| Barry Rohrssen als Referee |
| Sal Masekela |
| John Calipari |
| Jon Hammond |
| Scoop Jackson |
| Pee Wee Kirkland |
 | Earl Monroe |
| Chris Mullin |
 | Bill Walton als Self |
| George Gervin |
 | Steve Nash |
 | David Robinson als Self |
 | Jerry West |
| Dikembe Mutombo als Self |
 | Nene Leakes |
| Rick Barry |
 | Rick Ross |
 | Scott Van Pelt |
| Ben Nethongkome |
 | Crystal Lee Brown als Mom |
 | Jamel Chambers als Angry Fan |
 | Terence Rosemore als Customer #1 |
 | Gage Lawson als Teen Playing Basketball (uncredited) |
 | Alannah Wilhite als Girl in club |
 | Deadra Moore als Desk Nurse |
| Tinuke Adetunji als Angelo's Girl |
| Charles Stone III | Director |
| Sean Valla | Editor |
| Victoria Thomas | Casting |
| Louis Arbetter | Executive Producer |
| Jeff Freeman | Editor |
| Johnetta Boone | Costume Design |
| Jay Longino | Writer |
| Matthew Groves | Set Decoration |
| Doug J. Meerdink | Production Design |
| Karsten 'Crash' Gopinath | Director of Photography |
| Christopher Lennertz | Original Music Composer |
| Erik Feig | Executive Producer |
| John Fischer | Executive Producer |
| Colin Smeeton | Executive Producer |
| Mike Upton | Production Manager |
| Tim Fitzgerald | Second Assistant Director |
| Jon Poll | Additional Editor |
| Benita Allen | Co-Producer |
| Karen Jarnecke | Production Supervisor |
| Mark Garner | Art Direction |
| Matthew A. Petrosky | "A" Camera Operator |
| Matthew A. Petrosky | Steadicam Operator |
| Stephen Early | First Assistant "A" Camera |
| Taylor Fenno | Second Assistant "A" Camera |
| Michael Watson | "B" Camera Operator |
| Keith Pokorski | First Assistant "B" Camera |
| Bill McConnell Jr. | Second Assistant "B" Camera |
| Cristi Lyn Hahn | Second Assistant Camera |
| Caitlin Trost | Camera Loader |
| Joseph B. Dare | Digital Imaging Technician |
| Quantrell D. Colbert | Still Photographer |
| Sheryl Benko | Post Production Supervisor |
| Brett Carroll | Assistant Editor |
| Jason Barnoski | Assistant Editor |
| Carolyn Calvert | Assistant Editor |
| Derrick Mitchell | Visual Effects Editor |
| Lori Grabowski | Script Supervisor |
| Karen M. Cantley | Script Supervisor |
| Erik H. Magnus | Production Sound Mixer |
| Rob Disner | Boom Operator |
| Ross Jones | Key Grip |
| Marvin Haven | Dolly Grip |
| Chris Adkins | Grip |
| Steven A. Guerrero | Grip |
| Kevin Jackson | Rigging Grip |
| Joseph Kendrick | Rigging Grip |
| Anthony G. Nakonechnyj | Gaffer |
| Mike Davidson | Best Boy Electric |
| David Shakibanasab | Rigging Gaffer |
| Yolande Thame | Set Designer |
| Jeff Kujan | Art Department Coordinator |
| Yvette Carmen | Art Department Coordinator |
| Brian McKissick | Storyboard Artist |
| Connie Dominey | Graphic Designer |
| Joel Sisson | Leadman |
| Heather Bowers | Set Dresser |
| Brandon Pope | Greensman |
| Karen A. Felix | Property Master |
| Adrianne Skrzypek | Assistant Property Master |
| Ken Gorrell | Special Effects Coordinator |
| Darlene Jackson | Costume Supervisor |
| Molleshia Robinson | Key Costumer |
| Justin Boone | Key Costumer |
| Lanetra Butler | Key Costumer |
| Solomon Fuss | Key Costumer |
| Jennifer Williams-Davis | Key Costumer |
| Tamara Cobus | Seamstress |
| Ashli N. McLendon | Seamstress |
| Fontella Boone | Seamstress |
| Matthew Silva | Prosthetics |
| David Presto | Prosthetic Makeup Artist |
| Patrice Coleman | Makeup Department Head |
| Dionne Wynn | Makeup Artist |
| Parra Thomas | Makeup Artist |
| Michele Lewis | Key Makeup Artist |
| Travis Pates | Key Makeup Artist |
| Char Coats-Crump | Makeup Artist |
| Ellen Arden | Makeup Artist |
| Syretta L. Bell | Makeup Artist |
| Bridgit Crider | Makeup Artist |
| Noel Hernandez | Makeup Artist |
| Shantel Jordan | Makeup Artist |
| Saj Mack | Makeup Artist |
| Gindy Martin | Makeup Artist |
| Micah Laine | Makeup Artist |
| Andrea C. Brotherton | Hair Department Head |
| Talya Melvey | Key Hair Stylist |
| Tonya Cryer | Hairstylist |
| Steve Battaglia | Hairstylist |
| Tanya Bodison | Hairstylist |
| Iasia Merriweather | Hairstylist |
| Michealle Vanderpool | Hairstylist |
| Chantel Marie Wilson | Hairstylist |
| Keshia Winslow | Hairstylist |
| Kristi Lugo | Casting Assistant |
| Toni Avalos | Background Casting Director |
| Ryan Schaetzle | Location Manager |
| Matthew B. Chamberlin | Assistant Location Manager |
| Domonique Sonomi Magee | Location Coordinator |
| Donna Farmer | Production Accountant |
| Alison Cannon | Production Accountant |
| Leah M. Stricker | First Assistant Accountant |
| Cheryl D. Simms | Payroll Accountant |
| Liam Hearne | Post Production Accountant |
| Shantell Brown | Production Coordinator |
| Wendy Calloway | Assistant Production Coordinator |
| Telese Thomas | Production Secretary |
| Anthony Beckwith | Second Second Assistant Director |
| John Weeks | Construction Coordinator |
| Sam Zeines | Supervising Music Editor |
| Johnny Caruso | Music Editor |
| Sarah Bromberg | Music Coordinator |
