 | Hugh Jackman als Van Helsing |
 | Kate Beckinsale als Anna Valerious |
 | Richard Roxburgh als Count Vladislaus Dracula |
 | David Wenham als Carl |
 | Shuler Hensley als Frankenstein's Monster |
 | Elena Anaya als Aleera |
 | Will Kemp als Velkan |
 | Kevin J. O'Connor als Igor |
 | Alun Armstrong als Cardinal Jinette |
 | Silvia Colloca als Verona |
 | Josie Maran als Marishka |
 | Tom Fisher als Top Hat |
 | Samuel West als Dr. Victor Frankenstein |
 | Robbie Coltrane als Mr. Hyde (voice) |
 | Stephen Fisher als Dr. Jekyll |
 | Dana Morávková als Barmaid |
 | Zuzana Ďurdinová als Opera Singer |
 | Jaroslav Vízner als Gendarme |
 | Marek Vašut als Villager |
 | Samantha Sommers als Vampire Child |
| Dorel Mois als Dracula's Ball Performer |
| Marianna Mois als Dracula's Ball Performer |
| Laurence Racine als Dracula's Ball Performer |
| Patrice Wojciechowski als Dracula's Ball Performer |
 | Kacie Borrowman als Dwerger (uncredited) |
 | Martin Klebba als Dwerger (uncredited) |
 | Ryan James als Villager (uncredited) |
| Stephen Sommers | Director |
| Bob Ducsay | Producer |
| Stephen Sommers | Producer |
| Alan Silvestri | Original Music Composer |
| Stephen Sommers | Writer |
| Bob Ducsay | Editor |
| Kelly Matsumoto | Editor |
| Joanna Colbert | Casting |
| Priscilla John | Casting |
| Ellen Lewis | Casting |
| Allan Cameron | Production Design |
| Steve Arnold | Art Direction |
| Keith P. Cunningham | Art Direction |
| Giles Masters | Art Direction |
| Tony Reading | Art Direction |
| Cindy Carr | Set Decoration |
| Anna Pinnock | Set Decoration |
| Gabriella Pescucci | Costume Design |
| Carlo Poggioli | Costume Design |
| Nena Smarz | Makeup Department Head |
| Nick Scarano | Costume Supervisor |
| Nancy Smytka | Set Costumer |
| Susan Jennifer Lipson | Hairstylist |
| Sam Mercer | Executive Producer |
| Artist W. Robinson | Associate Producer |
| Gretchen Libby | Visual Effects Producer |
| Dawn Swiderski | Assistant Art Director |
| Karin Silvestri | Stunts |
| Wylie Griffin | Art Department Coordinator |
| Alex Cameron | Assistant Art Director |
| Butch West | Construction Coordinator |
| Robert E. Denne | Standby Painter |
| Paul C. Babin | Camera Operator |
| Craig Fikse | Steadicam Operator |
| Voni Hinkle | Hairstylist |
| Laura Baker | Set Costumer |
| Craig Hammack | CG Supervisor |
| Debra Brown | Choreographer |
| Jess Platt | Dialect Coach |
| Sean T. Stratton | Post Production Supervisor |
| Nicole Furia | Production Controller |
| JoAnn Perritano | Unit Production Manager |
| Guy Adan | Unit Publicist |
| Sylvie Chesneau | Script Supervisor |
| Vaclav Sramek | Editorial Production Assistant |
| Tzarina V. Edillon | First Assistant Editor |
| Dana Arnold | Rigging Gaffer |
| Jennifer Conroy | Production Coordinator |
| Anthony Ortiz | Boom Operator |
| John Finklea | Music Editor |
| Harry Cohen | Sound Designer |
| Christopher Assells | Sound Effects Editor |
| Karen Baker Landers | Supervising Sound Editor |
| Daniel Jeannette | Animation Supervisor |
| Lori Arnold | Visual Effects Coordinator |
| Jennifer Bell | Visual Effects Producer |
| Christian Alzmann | Visual Effects Art Director |
| Ben Snow | Visual Effects Supervisor |
| R.A. Rondell | Stunt Coordinator |
| Jim May | Editor |
| Shane Reed | Leadman |
| Eric Sundahl | Set Designer |
| Easton Michael Smith | Set Designer |
| Harry E. Otto | Set Designer |
| Tom Connole | Camera Operator |
| Rocky Quiroz | Cableman |
| Larry Wallace | Gaffer |
| Thomas L. Fisher | Special Effects Coordinator |
| Catherine Peña | Set Costumer |
| Silvia Raiano | Set Costumer |
| Jorge J. Gonzalez | Set Costumer |
| Serena Fiumi | Set Costumer |
| Vasilios Tanis | Makeup Artist |
| Colleen Callaghan | Key Hair Stylist |
| Keith VanderLaan | Makeup Effects |
| Mary Kim | Production Supervisor |
| James Traynor | Location Manager |
| Frank Masi | Still Photographer |
| Curt I. Miyashiro | CG Supervisor |
| Doug Smythe | CG Supervisor |
| Jeffrey Benedict | Sequence Supervisor |
| Ian Christie | Sequence Supervisor |
| Raul Essig | Sequence Supervisor |
| Carl N. Frederick | Sequence Supervisor |
| Jeremy Goldman | Sequence Supervisor |
| Robert Hoffmeister | Sequence Supervisor |
| Hayden Landis | Sequence Supervisor |
| Tia Marshall | Sequence Supervisor |
| Patrick Myers | Sequence Supervisor |
| Nigel Sumner | Sequence Supervisor |
| Thomas Zils | Sequence Supervisor |
| David Tanaka | Visual Effects Editor |
| Nicolas Anastassiou | Visual Effects Editor |
| Nina Fallon | Visual Effects Coordinator |
| Glenn Karpf | Visual Effects Coordinator |
| Gordon T. Wittmann | Visual Effects Coordinator |
| Jill E. Hughes | Visual Effects Coordinator |
| Laura Denicke | Visual Effects Coordinator |
| Mark McKenzie | Orchestrator |
| Greg Cannom | Makeup Effects Designer |
| Allen Daviau | Director of Photography |
| Scott Squires | Visual Effects Supervisor |
| Dawn Snyder | Assistant Art Director |
| Jann K. Engel | Set Designer |
| Luke Freeborn | Set Designer |
| Chris Munro | Production Sound Mixer |
| Renata Ryšavá | Set Costumer |
| Connie Kennedy | Visual Effects Coordinator |
| Nick Conti | Editorial Production Assistant |
| Per Hallberg | Supervising Sound Editor |
| Dino DiMuro | Sound Effects Editor |
| Ezra Dweck | Sound Effects Editor |
| Dan Hegeman | Sound Effects Editor |
| Peter Staubli | Sound Effects Editor |
| Bruce Tanis | Sound Effects Editor |
| Bryan Bowen | Sound Effects Editor |
| Scott Sanders | Sound Effects Editor |
| Harry Cohen | Sound Effects Editor |
| Sarah Peacock | Visual Effects Coordinator |
| Matthew Stillman | Associate Producer |
| David Minkowski | Associate Producer |
| Tad Griffith | Stunts |
| Tim Rigby | Stunts |
| Kimaree Long | Dialogue Editor |
| Frederick H. Stahly | Dialogue Editor |
| Steven Melton | Property Master |
| David Balfour | Property Master |
| David Parker | Sound Re-Recording Mixer |
| Leslie Shatz | Sound Re-Recording Mixer |
| Dennis S. Sands | Sound Re-Recording Mixer |
| Zack Davis | ADR Editor |
| Anna MacKenzie | ADR Editor |
| Michelle Pazer | ADR Editor |
| Victoria Rose Sampson | ADR Editor |
| Thomas Whiting | ADR Editor |
| David Lucarelli | ADR Recordist |
| Alexander Beddow | ADR Recordist |
| James Ashwill | Foley Mixer |
| Derek Thompson | Creature Design |
| Sean MacKenzie | Sequence Supervisor |
| Todd Vaziri | Compositing Lead |
| Mary Shelley | Characters |
| Hideki Arichi | Art Department Assistant |
| Todd Tucker | Assistant Makeup Artist |
| Jiřina Eisenhamerová | Costumer |
| Gregory B. Peña | Key Costumer |
| Maria Battle Campbell | Second Second Assistant Director |
| Greg Michael | Second Unit Director |
| Lukáš Líbal | Third Assistant Director |
| Jon Danniells | Assistant Decorator |
| Lance Larson | Assistant Property Master |
| Simon Murton | Concept Artist |
| Chris John Jones | Creative Director |
| Ellen Lampl | Graphic Designer |
| Jerry Bingham | Storyboard Artist |
| Derek Casari | ADR Engineer |
| Peter Gleaves | ADR Mixer |
| Michael Keller | Additional Sound Re-Recording Mixer |
| Tony Negrete | First Assistant Sound Editor |
| John T. Cucci | Foley Artist |
| Ryan Arndt | Special Effects Assistant |
| Steve Austin | Special Effects Technician |
| Carey Burens | Visual Effects Assistant Editor |
| Kelly Granite | Visual Effects Compositor |
| Bryan Park | Visual Effects Editor |
| Christine Castellano | Visual Effects Production Assistant |
| Richard Bradshaw | Stunt Double |
| Matthew A. Del Ruth | Assistant Camera |
| Kyle Carden | Best Boy Grip |
| Kevin Britton | Camera Production Assistant |
| Gary A. Beaird | Dolly Grip |
| John Bonnin | Libra Head Technician |
| Michal Krbeček | Second Assistant Camera |
| Rick O'Connor | CG Animator |
| Leslie Fulton | Lead Animator |
| Faith Allbeson | Casting Assistant |
| Ray Bushey III | Assistant Editor |
| Brano Danis | Colorist |
| Steven J. Scott | Digital Color Timer |
| Michael Healey | Digital Colorist |
| Nathan R. Fitzgerald | Digital Intermediate Editor |
| Terra Bliss | Digital Intermediate Producer |
| Hunter S. Ellis | Post Production Coordinator |
| Petr Skvor | Assistant Location Manager |
| Alan Silvestri | Conductor |
| Kenneth Karman | Supervising Music Editor |
| Janette Evans | Accountant |
| Kevin Roy | Additional Production Assistant |
| Michal Engrth | Assistant Accountant |
| Boban Dvorak | Assistant Production Coordinator |
| Florent Andorra | CG Artist |
| Marshall Richard Krasser | Compositing Supervisor |
| Kenneth Bailey | Creature Technical Director |
| Sean Apple | Digital Compositor |
| Harvey Lowry | Director of Operations |
| Judy Cook | Extras Casting |
| Jimmy Edwards | Fight Choreographer |
| Richard Castro | First Assistant Accountant |
| Donald Fly | General Manager |
| Kristen Leigh Branan | Head of Production |
| Jordan Wilby | Intern |
| Justin Hamilton Salem | Key Set Production Assistant |
| Steve LaPorte | Key Special Effects |
| David Romano | Payroll Accountant |
| Katherine Farrar | Production Assistant |
| Gary J. Gross | Production Consultant |
| Terry R. Owens | Production Driver |
| Kelly E. Norris | Production Secretary |
| Roxanne Sutherland-Valentine | Receptionist |
| Erin King | Rotoscoping Artist |
| Carole Humphreys | Second Assistant Accountant |
| Tory Belleci | Modeling |
| Lou Kleinman | Sound Editor |
| John T. Sweeney | Production Coordinator |
| Bram Stoker | Characters |
| Armen Ksajikian | Musician |
| Heidi Moneymaker | Stunts |
| Chad Stahelski | Fight Choreographer |
| David Leitch | Stunt Double |
| Karin Silvestri | Stunt Double |
| Freddie Hice | Stunts |
| Oakley Lehman | Stunts |
| Matt McColm | Stunt Double |
| Billy D. Lucas | Stunts |
| Karine Mauffrey | Stunts |
| Debbie Lee Carrington | Stunts |
| Danny Wynands | Stunts |
| Tim Trella | Stunts |
| Petr Horáček | Stunts |
