 | Bill Murray als Bob Wiley |
 | Richard Dreyfuss als Dr. Leo Marvin |
 | Julie Hagerty als Fay Marvin |
 | Charlie Korsmo als Sigmund "Siggy" Marvin |
 | Kathryn Erbe als Anna Marvin |
 | Tom Aldredge als Mr. Guttman |
 | Susan Willis als Mrs. Guttman |
 | Roger Bowen als Phil |
 | Fran Brill als Lily Marvin |
 | Brian Reddy als Carswell Fensterwald, M.D. |
 | Doris Belack als Dr. Catherine Tomsky |
 | Melinda Mullins als Marie Grady |
 | Marcella Lowery als Betty, Switchboard Operator |
 | Margot Welch als Gwen, Switchboard Operator |
| Barbara Andres als Claire, Dr. Marvin's Secretary |
| Aida Turturro als Prostitute |
 | Joan Lunden als TV Announcer |
| Dennis Scott als Motorcycle Cop |
 | Richard Fancy als Minister |
| Cortez Nance Jr. als Lobby Doorman |
 | Reg E. Cathey als Howie / Director |
 | Tom Stechschulte als Lennie / Producer |
 | Russell Bobbitt als TV Crew Member |
 | Stuart Rudin als Crazy Man |
| Charles Thomas Baxter als Nursing Home Guard |
 | Donald J. Lee Jr. als Nursing Home Attendant |
| Frank Oz | Director |
| Tom Schulman | Screenplay |
| Laura Ziskin | Producer |
| Miles Goodman | Original Music Composer |
| Michael Ballhaus | Director of Photography |
| Anne V. Coates | Editor |
| Glenn Daniels | Casting |
| Leslie Dilley | Production Design |
| Jack Blackman | Art Direction |
| Anne Kuljian | Set Decoration |
| Bernie Pollack | Costume Design |
| Michael R. Clark | Painter |
| John K. Carr | Sound Editor |
| Richard O. Helmer | Special Effects Supervisor |
| Michael Steve Jones | Stunts |
| Alvin Sargent | Story |
| Laura Ziskin | Story |
| Bernard Williams | Co-Producer |
| Emanuel Millar | Hairstylist |
| Matthew W. Mungle | Makeup Artist |
| David C. Anderson | Unit Production Manager |
| Donald J. Lee Jr. | Second Assistant Director |
| James W. Skotchdopole | First Assistant Director |
| Russell Bobbitt | Property Master |
| Roger G. Fortune | Set Designer |
| Douglas Fox | Property Master |
| Donald G. Helderle | Construction Foreman |
| Frank B. Nieves | Construction Foreman |
| Ken Scaife | Construction Coordinator |
| Wayne Shepherd | Leadman |
| Brett C. Smith | Set Dresser |
| Bruce Bell | Foley Mixer |
| Liz Carlin | Assistant Sound Editor |
| David Grannis | Assistant Sound Editor |
| Catherine Harper | Foley Artist |
| Devon Heffley Curry | ADR Editor |
| Pieter Hubbard | Sound Editor |
| David J. Hudson | Sound Re-Recording Mixer |
| Doc Kane | ADR Mixer |
| Kenneth C. Mantlo | Boom Operator |
| Mel Metcalfe | Sound Re-Recording Mixer |
| Bill Phillips | Supervising Sound Editor |
| John Phillips | Sound Editor |
| Terry Porter | Sound Re-Recording Mixer |
| Hal Sanders | Sound Editor |
| Scott Shadden | Assistant Sound Editor |
| Edward M. Steidele | Foley Artist |
| Ed White | Sound Mixer |
| Stuart Abramson | Key Grip |
| Florian Ballhaus | First Assistant Camera |
| Arthur Blum | Dolly Grip |
| David M. Dunlap | Camera Operator |
| Craig Kohtala | Best Boy Grip |
| Bobby Mancuso | Second Assistant Camera |
| Robert W. Meyers | Rigging Gaffer |
| James R. Tynes | Chief Lighting Technician |
| Barry Wetcher | Still Photographer |
| Hugo Peña | Costume Supervisor |
| Christopher Cibelli | Assistant Editor |
| James D.R. Hickox | Assistant Editor |
| Sandy Isaac | Post Production Coordinator |
| Charles Thomas Baxter | Location Manager |
| Nancy Fogarty | Music Editor |
| Susan Malerstein | Script Supervisor |
| Rafe Blasi | Unit Publicist |
| Lisa Lynn Kearsley | Production Coordinator |
| Tandi Slater | Production Accountant |
| Dana Williams | Production Coordinator |
| Dennis Scott | Stunt Coordinator |
| Steve Hart | Stunts |
| James Kindelon | Stunts |
| Ted Barba | Stunts |
| Bobby Burns | Stunt Double |
