 | Will Smith als Capt. James West |
 | Kevin Kline als U.S. Marshal Artemus Gordon / President Grant |
 | Kenneth Branagh als Dr. Arliss Loveless |
 | Salma Hayek Pinault als Rita Escobar |
 | M. Emmet Walsh als Coleman |
 | Ted Levine als General 'Bloodbath' McGrath |
 | Frederique van der Wal als Amazonia |
 | Musetta Vander als Munitia |
 | Sofia Eng als Miss Lippenrieder |
 | Garcelle Beauvais als Belle |
 | Bai Ling als Miss East |
 | Rodney A. Grant als Hudson |
 | E.J. Callahan als Mr. Pinkerton |
 | Debra Christofferson als Dora Look-Alike |
 | Buck Taylor als Cross-Eyed Reb |
 | James Lashly als Reb #1 |
 | Dean Rader Duval als Reb #2 |
 | Jerry Wills als Other Reb |
| Mike H. McGaughy als Big reb |
| Christian Aubert als French Dignitary |
 | Orestes Matacena als Spanish Dignitary |
 | Ian Abercrombie als British Dignitary |
 | Ismael 'East' Carlo als Mexican Dignitary |
 | Bob Rumnock als White House Aide |
 | Gary Carlos Cervantes als Dr. Guillermo Escobar |
 | Jerry Potter als George Washington |
 | Mik Scriba als Guard |
| Michael Sims als Prof. Thaddeus Morton |
 | J.J. Perry als Shovel Guy (uncredited) |
 | Dennis Keiffer als Wrench Guy (uncredited) |
 | Derek Mears als Metal Head (uncredited) |
| Barry Sonnenfeld | Director |
| Jeffrey Price | Screenplay |
| Peter S. Seaman | Screenplay |
| Jon Peters | Producer |
| S.S. Wilson | Screenplay |
| Elmer Bernstein | Original Music Composer |
| Brent Maddock | Screenplay |
| Barry Sonnenfeld | Producer |
| Stefan Czapsky | Director of Photography |
| Jim Miller | Editor |
| Michael Ballhaus | Director of Photography |
| Alex Madison | Stunts |
| Tim Rigby | Stunts |
| Tad Griffith | Stunts |
| Steve Braggs | CG Supervisor |
| Chick Bernhard | Stunt Double |
| Bo Welch | Production Design |
| Ronna Kress | Casting |
| Eric Brevig | Visual Effects Supervisor |
| Kim LeMasters | Executive Producer |
| Doug Lodato | Co-Producer |
| Tracy Glaser | Executive Producer |
| Joel Simon | Executive Producer |
| Jim Thomas | Story |
| John Thomas | Story |
| Mary Bailey | Script Supervisor |
| Bill Todman Jr. | Executive Producer |
| Barry Josephson | Executive Producer |
| Rick Baker | Makeup Effects Designer |
| Dale E. Grahn | Color Timer |
| Mo Henry | Negative Cutter |
| Graham Place | Co-Producer |
| Cheryl Carasik | Set Decoration |
| David Rubin | Casting |
| Deborah Lynn Scott | Costume Design |
| Tom Duffield | Art Direction |
| Graham Place | Unit Production Manager |
| Chris Soldo | First Assistant Director |
| David H. Venghaus Jr. | Second Assistant Director |
| Neri Kyle Tannenbaum | Associate Producer |
| Chris Soldo | Associate Producer |
| Russ Kavanaugh | Post Production Supervisor |
| Karen M. Murphy | Visual Effects Producer |
| Jacqui Lopez | Visual Effects Producer |
| Daniel C. Gold | "A" Camera Operator |
| Patrick M. Sullivan | Set Designer |
| Maya Shimoguchi | Set Designer |
| Gerald Sullivan | Set Designer |
| Mariko Braswell | Set Designer |
| Sean Haworth | Assistant Art Director |
| James R. Tynes | Chief Lighting Technician |
| Stephen St. John | "B" Camera Operator |
| Stephen St. John | Steadicam Operator |
| J. Patrick Daily | Key Grip |
| Peter F. Kurland | Sound Mixer |
| Steve Bowerman | Boom Operator |
| Skip Lievsay | Supervising Sound Editor |
| Bobby Mackston | Supervising Sound Editor |
| Kevin O'Connell | Sound Re-Recording Mixer |
| Greg P. Russell | Sound Re-Recording Mixer |
| John Pospisil | Sound Designer |
| John P. Fasal | Sound Designer |
| Eugene Gearty | Sound Designer |
| Juno J. Ellis | Supervising ADR Editor |
| Thomas J. O'Connell | ADR Mixer |
| Marko Costanzo | Foley Artist |
| Dan O'Connell | Foley Artist |
| John T. Cucci | Foley Artist |
| George A. Lara | Foley Mixer |
| James Ashwill | Foley Mixer |
| Jane E. Russell | Unit Publicist |
| Murray Close | Still Photographer |
| Emilie A. Bernstein | Orchestrator |
| Kathy Durning | Music Editor |
| Patricia Carlin | Music Editor |
| Eric Tignini | Second Second Assistant Director |
| Whitney James | Key Makeup Artist |
| Teresa M. Austin | Makeup Artist |
| Robin Beauchesne | Makeup Artist |
| Judy Murdock | Makeup Artist |
| Martin Samuel | Key Hair Stylist |
| Lucia Mace | Hairstylist |
| Doug Harlocker | Property Master |
| Michael Lantieri | Special Effects Supervisor |
| Maryellen Aviano | Extras Casting |
| Kenny Searle | Transportation Coordinator |
| Terry Leonard | Second Unit Director |
| Eric Brevig | Second Unit Director |
| Mark Hicks | Stunts |
| Mark Hicks | Stunt Double |
| Chad Stahelski | Stunts |
| Terry Leonard | Stunt Coordinator |
| Jeannie Epper | Stunts |
| Anita Hart | Stunts |
| Cinda-Lin James | Stunts |
| Loren Janes | Stunts |
| Larry Holt | Stunts |
| Annie Ellis | Stunts |
| Diana Lee Inosanto | Stunt Double |
| J.J. Perry | Stunts |
| Troy Robinson | Stunts |
| Troy Brown | Stunts |
| Gary Epper | Stunts |
| Freddie Hice | Stunts |
| Gary J. Wayton | Stunts |
| Laura Albert | Stunts |
| Danny Epper | Stunts |
| Joe Bucaro III | Stunts |
| Darrin Prescott | Stunts |
| Lane Leavitt | Stunts |
| Tim Trella | Stunts |
| Pat Romano | Stunts |
| Jeanie King | Visual Effects Coordinator |
| Norman Howell | Stunts |
