 | Michael Caine als Sherlock Holmes |
 | Ben Kingsley als Dr. John Watson |
 | Jeffrey Jones als Inspector Lestrade |
 | Lysette Anthony als Impostor Leslie Giles |
 | Nigel Davenport als Lord Smithwick |
 | Peter Cook als Greenhough |
 | Gregor Fisher als Bobby at Warehouse |
 | Paul Freeman als Prof. James Moriarty |
 | George Sweeney als John Clay |
 | John Tordoff als Mr. Andrews |
 | Alexandra Spencer als Mrs. Andrews |
 | Matthew Sim als Real Lesley |
 | Pat Keen als Mrs. Hudson |
 | Matthew Savage als Wiggins |
 | Tim Killick als Sebastian |
 | John Warner als Peter Giles |
 | Harold Innocent als Mayor Johnson |
 | Murray Ewan als Archie |
 | Stephen Tiller als Reporter #1 |
 | Michael O'Hagan als Reporter #2 |
 | Ivor Roberts als Reporter #3 |
 | Martin Pallot als Photographer |
 | Caroline Milmoe als Constance |
 | Steven O'Donnell als Bartender |
 | James Bree als Barrister |
 | Clive Mantle als Thug #1 |
 | Dave Cooper als Thug #2 |
 | Andy Bradford als Dockworker |
 | Jennifer Guy als Christabel |
 | Elizabeth Kelly als Landlady |
 | Lesley Daine als Lady on Train |
 | John Surman als Constable at Lakes |
| Thom Eberhardt | Director |
| Gary Murphy | Screenplay |
| Larry Strawther | Screenplay |
| Marc Stirdivant | Producer |
| Henry Mancini | Original Music Composer |
| Alan Hume | Director of Photography |
| Peter Tanner | Editor |
| Jim Smart | Electrician |
| Diana Buckhantz | Associate Producer |
| Ben Moses | Associate Producer |
| Noel Davis | Casting |
| Jeremy Zimmermann | Casting |
| Brian Ackland-Snow | Production Design |
| Martyn Hebert | Production Design |
| Peter James | Set Decoration |
| Ian Whittaker | Set Decoration |
| Judy Moorcroft | Costume Design |
| Lois Burwell | Makeup Artist |
| Sandra Exelby | Assistant Makeup Artist |
| Terry Ackland-Snow | Art Direction |
| Robin Tarsnane | Art Direction |
| Peter Frampton | Makeup Artist |
| Betty Glasow | Hairdresser |
| Stevie Hall | Hairdresser |
| Tracy Smith | Assistant Hairdresser |
| Christabel Albery | Production Supervisor |
| John Forrest Niss | Post Production Supervisor |
| Don French | First Assistant Director |
| Gerry Toomey | Second Assistant Director |
| Kevin Westley | Third Assistant Director |
| Amanda Ackland-Snow | Assistant Set Decoration |
| Andrew Ackland-Snow | Assistant Art Director |
| Dennis Fruin | Property Master |
| Ian Giladjian | Property Buyer |
| Peter Palmer | Property Buyer |
| Vic Simpson | Construction Manager |
| Bill Stallion | Storyboard Artist |
| Wayne Artman | Sound Re-Recording Mixer |
| Gregg Baxter | ADR Editor |
| Tom Beckert | Sound Re-Recording Mixer |
| Desmond Cannon | Assistant Sound Editor |
| Tom E. Dahl | Sound Re-Recording Mixer |
| Lee Dragu | Foley Editor |
| James Dean Fisher | Foley Artist |
| David Hildyard | Sound Recordist |
| Russ Hill | Dialogue Editor |
| Eddy Joseph | Dialogue Editor |
| Mike Le Mare | Supervising Sound Editor |
| Anthony Palk | Sound Effects Editor |
| Keith Pamplin | Boom Operator |
| Carolann Sanchez-Shapiro | Assistant Sound Editor |
| Steve Schwalbe | Assistant Sound Editor |
| Karola Storr | Foley Editor |
| Ian Wingrove | Special Effects Supervisor |
| Paul Weston | Stunt Coordinator |
| Rocky Taylor | Stunts |
| Graham Attwood | Still Photographer |
| Bob Bremner | Gaffer |
| Bob Gomme | Genetator Operator |
| Graham Hall | Clapper Loader |
| Martin Hume | Camera Operator |
| Simon Hume | Focus Puller |
| Alec King | Electrician |
| Terry Townsend | Electrician |
| Keith Morton | Wardrobe Supervisor |
| Sue Wain | Wardrobe Master |
| Natalie Baker | Assistant Editor |
| Joanne Chee | Post Production Coordinator |
| Carl Graham | Assistant Editor |
| Harry Hitner | Assistant Editor |
| Ron Wengler | Color Timer |
| Stephen A. Hope | Music Editor |
| Annie Penn | Script Supervisor |
| Harriet Fenner | Production Coordinator |
| Patrick Isherwood | Production Accountant |
| Ben Montanio | Production Controller |
| Pamela Parker | Production Coordinator |
