 | Hugh Jackman als Logan / Wolverine |
 | Patrick Stewart als Charles Xavier / Professor X |
 | Ian McKellen als Eric Lehnsherr / Magneto |
 | Famke Janssen als Jean Grey / Phoenix |
 | Halle Berry als Ororo Munroe / Storm |
 | Anna Paquin als Marie D'Ancanto / Rogue |
 | Shawn Ashmore als Bobby Drake / Ice Man |
 | Aaron Stanford als John Allerdyce / Pyro |
 | Alan Cumming als Kurt Wagner / Nightcrawler |
 | Brian Cox als William Stryker |
 | Rebecca Romijn als Raven Darkholme / Mystique / Grace |
 | James Marsden als Scott Summers / Cyclops |
 | Kelly Hu als Yuriko Oyama / Lady Deathstrike |
 | Michael Reid MacKay als Jason 143 |
 | Bruce Davison als Senator Kelly |
 | Katie Stuart als Katherine "Kitty" Pryde / Shadowcat |
 | Ty Olsson als Mitchell Laurio |
 | Daniel Cudmore als Piotr Rasputin / Colossus |
 | Cotter Smith als President McKenna |
 | James Kirk als Ronny Drake |
 | Jill Teed als Madeline Drake |
 | Alf Humphreys als William Drake |
 | Kea Wong als Jubilation Lee / Jubilee |
 | Chiara Zanni als White House Tour Guide |
 | Jackie A. Greenbank als President's Secretary |
| Michael Soltis als White House Checkpoint Agent |
 | Michael David Simms als White House Agent (Lead Agent) |
 | David Fabrizio als Oval Office Agent Fabrizio |
 | Roger Cross als Oval Office Agent Cartwright |
 | Richard Bradshaw als Special Ops Agent |
 | Bryce Hodgson als Artie |
| Glen Curtis als Museum Teenager #1 |
 | Greg Rikaart als Museum Teenager #2 |
| Shauna Kain als Theresa Rourke / Siryn |
 | Alfonso Quijada als Federal Bldg. Cleaning Twin #1 |
| Rene Quijada als Federal Bldg. Cleaning Twin #2 |
 | Brad Loree als Stryker at age 40 |
| Sheri G. Feldman als Augmentation Room Doctor |
 | Connor Widdows als Jones |
 | Peter Wingfield als Stryker Soldier Lyman |
 | Charles Siegel als Dr. Shaw |
 | Steve Bacic als Dr. Hank McCoy |
 | Michasha Armstrong als Plastic Prison Guard |
 | Robert Hayley als Cop |
 | Mark Lukyn als Cop #1 (Lead Cop) |
 | Kendall Cross als Cop #2 |
| Keely Purvis als Little Girl 143 |
 | Dylan Kussman als Stryker Soldier Wilkins |
| Jason S. Whitmer als Stryker Soldier Smith |
 | Aaron Pearl als Stryker Soldier |
 | Aaron Douglas als Stryker Soldier |
 | Colin Lawrence als Stryker Soldier |
 | Richard C. Burton als Stryker Soldier |
| Michael Joycelyn als Stryker Soldier |
 | Nolan Gerard Funk als X-Kid (captured) |
 | Devin Douglas Drewitz als X-Kid (captured) |
| Jermaine Lopez als X-Kid (captured) |
| Sideah Alladice als X-Kid (captured) |
 | Kurt Max Runte als Chief of Staff Abrahams |
 | Benjamin Glenday als Cameraman |
| Lori Stewart als F-16 Fighter Pilot |
 | Ted Friend als News Reporter |
 | Mi-Jung Lee als News Reporter |
 | Marrett Green als News Reporter |
 | Jill Krop als News Reporter |
 | Brian Peck als News Reporter |
 | Layke Anderson als Douglas Ramsey / Cypher |
| Michael Dougherty als Surgeon |
| Dan Harris als Surgeon |
 | Bryan Singer als Prison Security Officer (uncredited) |
 | Nikita Ramsey als Twin X-Kid (uncredited) |
 | Jade Ramsey als Twin X-Kid (uncredited) |
 | Valerie Tian als X-Kid at Museum (sin acreditar) |
| Dan Harris | Screenplay |
| Zak Penn | Story |
| David Hayter | Story |
| Bryan Singer | Story |
| Michael Dougherty | Screenplay |
| David Hayter | Screenplay |
| Bryan Singer | Director |
| Terry Notary | Choreographer |
| Elizabeth Wilcox | Set Decoration |
| Lauren Shuler Donner | Producer |
| John Ottman | Editor |
| Ralph Winter | Producer |
| Newton Thomas Sigel | Director of Photography |
| Guy Hendrix Dyas | Production Design |
| John Ottman | Music |
| Louise Mingenbach | Costume Design |
| Helen Jarvis | Art Direction |
| Roger Mussenden | Casting |
| Geoff Hubbard | Supervising Art Director |
| Angie Jones | Animation |
| Andy Asperin | Animation |
| James Bamford | Stunts |
| J.J. Makaro | Stunts |
| Michael Herbick | Sound Mixer |
| Jeffrey Cassidy | Video Assist Operator |
| Christine Wilson | Script Supervisor |
| Rick Newsome | Storyboard Designer |
| Selwyn Roberts | Line Producer |
| Ross T. Fanger | Co-Producer |
| John H. Radulovic | Line Producer |
| Bryan Singer | Executive Producer |
| Tom DeSanto | Executive Producer |
| David Gorder | Associate Producer |
| Stan Lee | Executive Producer |
| Avi Arad | Executive Producer |
| Ray McIntyre Jr. | Visual Effects Supervisor |
| Melanie Cassidy | Art Department Assistant |
| Michael L. Fink | Visual Effects Supervisor |
| Gordon J. Smith | Special Effects Makeup Artist |
| Ross T. Fanger | Unit Production Manager |
| Stewart Bethune | Unit Production Manager |
| Lee Cleary | First Assistant Director |
| David Arnold | Second Assistant Director |
| Jason McGatlin | Production Supervisor |
| Barbara Wilson | Assistant Art Director |
| Brentan Harron | Assistant Art Director |
| Ignacio McBurney | Assistant Set Decoration |
| Ron Sowden | Assistant Set Decoration |
| Franziska Keller | Art Department Coordinator |
| Aimee Rousey | Art Department Coordinator |
| Gerrod Shully | Second Second Assistant Director |
| Silver Butler | Third Assistant Director |
| Tim Merkel | Steadicam Operator |
| Tim Merkel | "B" Camera Operator |
| Jimmy E. Jensen | First Assistant "A" Camera |
| Sean M. Harding | First Assistant "B" Camera |
| Kerry Hayes | Still Photographer |
| Doane Gregory | Still Photographer |
| Rob Young | Sound Mixer |
| Jon Lavender | Boom Operator |
| Andy Bishop | Cableman |
| Jimmy Chow | Property Master |
| Catherine Leighton | Assistant Property Master |
| Jason B. Landels | Assistant Property Master |
| Rob Fournier | Armorer |
| Steve Smith | Key Grip |
| Cathy Crandall | Assistant Costume Designer |
| Janice Swayze | Costume Coordinator |
| Dov Samuel | First Assistant Editor |
| John A. Larsen | Supervising Sound Editor |
| Paul Massey | Sound Re-Recording Mixer |
| Doug Hemphill | Sound Re-Recording Mixer |
| Michael Herbick | Sound Re-Recording Mixer |
| Susan Dawes | Dialogue Editor |
| Jim Brookshire | Dialogue Editor |
| Donald Sylvester | ADR Supervisor |
| Laura Graham | ADR Editor |
| John Morris | Foley Supervisor |
| Amanda Goodpaster | Music Editor |
| Gary Burritt | Negative Cutter |
| Jim Passon | Color Timer |
| Chris Regan | Color Timer |
| Elliot Graham | Co-Editor |
| Elliot Graham | Editor |
| Doug Chapman | Stunts |
| Kevin Feige | Co-Producer |
| Melissa R. Stubbs | Stunt Coordinator |
| Marny Eng | Stunt Double |
| Rick Pearce | Stunts |
| Brian Smrz | Second Unit Director |
| Dane Farwell | Stunts |
| Lauro Chartrand | Stunts |
| Andrew Tamandl | VFX Artist |
