 | Vin Diesel als Xander Cage |
 | Donnie Yen als Xiang |
 | Ruby Rose als Adele Wolff |
 | Toni Collette als Jane Marke |
 | Samuel L. Jackson als Agent Augustus Gibbons |
 | Ice Cube als Darius Stone / xXx |
 | Rory McCann als Tennyson Torch |
 | Nina Dobrev als Rebecca 'Becky' Clearidge |
 | Deepika Padukone als Serena Unger |
 | Tony Jaa als Talon |
 | Kris Wu als Nicks |
 | Hermione Corfield als Ainsley |
 | Michael Bisping als Hawk |
 | Shawn Roberts als Jonas |
 | Tony Gonzalez als Paul Donovan |
 | Ariadna Gutiérrez als Lola |
 | Andrey Ivchenko als Red Erik |
 | Nicky Jam als Lazarus |
 | Neymar Jr als Neymar Jr |
 | Al Sapienza als CIA Director |
 | Helena-Alexis Seymour als Ainsley's Girl |
 | Megan Soo als Ainsley's Girl |
 | Kristen Kurnik als Ainsley's Girls |
 | Bailey Rose King als Ainsley's Girls |
 | Pilar Cruz als Ainsley's Girls |
 | Charles Carroll als Friendly Man |
 | Héctor Aníbal als Swat Captain |
 | Curtis Fletcher als Minister |
 | Terry Chen als Chinese Politico |
 | Jenny Itwaru als Catwalk Partiers |
 | Julie Abcede als Catwalk Partiers |
 | Josh Pagcaliwangan als Catwalk Partiers |
 | Nyjah Huston als Nyjah Huston |
 | Roberta Mancino als Roberta Mancino |
 | Nina Buitrago als Nina Buitrago |
 | Dani Lightningbolt als Dani Lightningbolt |
 | Courtney Friel als Newscaster |
 | Jelena Savić als Catwalk Partier |
| Glorianna Sulbaran als Lazarus' Girl |
| Rebecca Leung als Island Bartender |
 | Daniel Kash als Russian Spymaster |
| D. J. Caruso | Director |
| Rich Wilkes | Characters |
| Joe Roth | Producer |
| Samantha Vincent | Producer |
| Jeff Kirschenbaum | Producer |
| Vin Diesel | Producer |
| Russell Carpenter | Director of Photography |
| F. Scott Frazier | Writer |
| Scott Hemming | Executive Producer |
| Denis Dvoryankin | Animation |
| David Crispino | Animation Supervisor |
| Kimberly A. Tillman | Costume Design |
| Lyn Lucibello | Unit Production Manager |
| Karen Jarnecke | Production Supervisor |
| Gloria S. Borders | Executive Producer |
| Shane Richards | Animation |
| Matthew Llewellyn | Music Editor |
| Carol Hartwick | Key Hair Stylist |
| Allan A. Apone | Makeup Department Head |
| Trey Harrell | CG Supervisor |
| Karen Lee | Costume Coordinator |
| Robert Settlemire | Underwater Camera |
| Richard Emerson | Key Grip |
| Mark Sussman | ADR Voice Casting |
| David Emmerichs | Second Unit Director of Photography |
| Annelie Dangel | Visual Effects Coordinator |
| Thomas Nittmann | Visual Effects Producer |
| Anne McCarthy | Casting |
| John Holosko | Camera Operator |
| Jason Vieira | Camera Operator |
| Byrd Dickens | Rigging Gaffer |
| Jo-Ann MacNeil | Makeup Designer |
| Cindy Rosenthal | Key Costumer |
| Ian Anderson | Camera Operator |
| Peter Zuccarini | Underwater Director of Photography |
| Adam Pere | Visual Effects Coordinator |
| Joyce Au | Visual Effects Coordinator |
| Vincent Sullivan | Hair Department Head |
| Debra Denson | Makeup Artist |
| Amanda H. Campbell | Visual Effects Coordinator |
| Björn Mayer | Visual Effects Supervisor |
| Charles Taylor | Armorer |
| Kyle Clausen | Music Editor |
| Angelo Colavecchia | Steadicam Operator |
| Cecilia Marin | Visual Effects Producer |
| Sean Sansom | Tattoo Designer |
| Nick Bernardi | Visual Effects Coordinator |
| Greg Hopwood | Costume Illustrator |
| Keith Murphy | Camera Operator |
| Ashley Rocha | Makeup Artist |
| Eric Robinson | Visual Effects Supervisor |
| Michael Gibson | Still Photographer |
| Patrick Krauter | Dolly Grip |
| Morgan Robbins | Casting Associate |
| Justin M. Lubin | Still Photographer |
| Danielle Davis | Visual Effects Coordinator |
| Luke Groves | Visual Effects Producer |
| Ian Cope | Visual Effects Producer |
| Janice Skinner | Key Costumer |
| Patty Connolly | ADR Voice Casting |
| Kevin McKeever | Music Editor |
| Renee Fontana | Assistant Costume Designer |
| Wayne Godfrey | Key Costumer |
| Michael Carella | Camera Operator |
| Michael Galbraith | Gaffer |
| Alastair Muir | Makeup Department Head |
| Jasen Nannini | Visual Effects Supervisor |
| Vicente Parada | Costume Supervisor |
| Samuel Kosub | Lighting Technician |
| Sina Sultani | Visual Effects Coordinator |
| Chelsea Mirus | Visual Effects Coordinator |
| Miguel Fernandez | Casting |
| Edna Lerebours | Casting |
| Daniela Saioni | Script Supervisor |
| Alex Kavanagh | Costume Supervisor |
| Tom Comet | Drone Operator |
| Roxy D'Alonzo | Makeup Artist |
| Steve Newburn | Prosthetic Supervisor |
| Daniel Baker | Visual Effects Coordinator |
| Loeng Wong-Savun | Visual Effects Supervisor |
| Adam Heinis | Special Effects Coordinator |
| Elizabeth Hitt | Digital Intermediate |
| Jennifer Stellema | First Assistant Editor |
| Jessie Pariseau | Sound Effects Editor |
| Dan O'Connell | Foley |
| Ann Scibelli | Sound Designer |
| D. Chris Smith | Sound Effects Editor |
| Ron Bartlett | Sound Re-Recording Mixer |
| Peter Chesney | Special Effects Supervisor |
| Laird McMurray | Special Effects Coordinator |
| Lluís Rivera | Special Effects Coordinator |
| Peter Staubli | Sound Designer |
| Marc Banich | Special Effects Supervisor |
| David Werntz | Sound Designer |
| D. Chris Smith | Foley Editor |
| Joe Ken | Digital Intermediate |
| John T. Cucci | Foley |
| Zack Haskell | Aerial Camera |
| Colin Woods | Art Direction |
| Christopher Geggie | Property Master |
| Jon Billington | Production Design |
| Brandt Gordon | Supervising Art Director |
| Daniel Saxlid | Dialogue Editor |
| Vince Filippone | Editor |
| Glen Gauthier | Sound Mixer |
| Jim Page | Editor |
| Brian Tyler | Original Music Composer |
| Robert Lydecker | Original Music Composer |
| Dusty Reeves | Art Department Coordinator |
| John C. Stuver | Dialogue Editor |
| Shane Vieau | Set Decoration |
| John Carey | Music Arranger |
| Alicia Turner | Stunt Double |
| Donnie Yen | Fight Choreographer |
| Darrell Hicks | Stunt Driver |
| Matteo Veglia | VFX Production Coordinator |
| Michael Furniss | Visual Effects |
| Stephannie Hawkins | Stunts |
| Ric Kidney | Executive Producer |
| Zack Roth | Executive Producer |
| Vince Totino | Executive Producer |
| Troy Robinson | Stunt Coordinator |
| Bob Brown | Stunt Coordinator |
| Oakley Lehman | Stunts |
| Larissa Stadnichuk | Stunt Double |
| Dan Bradley | Second Unit Director |
| Allan Wylie | Video Assist Operator |
| Hannah Betts | Utility Stunts |
| David Murphy | Key Carpenter |
| David Murphy | Carpenter |
| Dana Howes | Transportation Coordinator |
| Arlene Halpenny-Heeley | Cast Driver |
| Mickey Giacomazzi | Stunts |
| Todd Harris | Storyboard Artist |
