 | Keanu Reeves als Bob Arctor |
 | Robert Downey Jr. als James Barris |
 | Woody Harrelson als Ernie Luckman |
 | Winona Ryder als Donna Hawthorne |
 | Rory Cochrane als Charles Freck |
 | Mitch Baker als Brown Bear Lodge Host |
 | Sean Allen als Additional Fred Scramble Suit Voice (voice) |
| Cliff Haby als Voice from Headquarters (voice) |
 | Steven Chester Prince als Cop |
| Natasha Valdez als Waitress |
| Mark Turner als Additional Hank Scramble Suit Voice (voice) |
 | Chamblee Ferguson als Medical Deputy #2 |
 | Angela Rawna als Medical Deputy #1 |
| Eliza Stevens als Arctor's Daughter #1 |
| Sarah Menchaca als Arctor's Daughter #2 |
 | Melody Chase als Arctor's Wife |
| Leif Anders als Freck Suicide Narrator (voice) |
 | Turk Pipkin als Creature |
 | Alex Jones als Street Prophet |
 | Lisa Marie Newmyer als Connie |
 | Wilbur Penn als Medical Officer #1 |
 | Ken Webster als Medical Officer #2 |
| Hugo Perez als New Path Staff Member #1 |
| Rommel Sulit als New Path Staff Member #2 |
 | Dameon Clarke als Mike |
| Christopher Ryan als New Path Resident #1 |
| Leila Plummer als New Path Resident #2 |
 | Jason Douglas als New Path Farm Manager |
 | Marco Perella als Donald |
 | Gary Teague als Brown Bear Lodge Member (uncredited) |
| Richard Linklater | Director |
| Richard Linklater | Screenplay |
| Philip K. Dick | Novel |
| Jonah Smith | Producer |
| Tommy Pallotta | Producer |
| Anne Walker-McBay | Producer |
| Palmer West | Producer |
| Graham Reynolds | Original Music Composer |
| Shane F. Kelly | Director of Photography |
| Sandra Adair | Editor |
| Bruce Curtis | Production Design |
| Joaquin A. Morin | Set Decoration |
| Erwin Stoff | Producer |
| George Clooney | Executive Producer |
| Ben Cosgrove | Executive Producer |
| Jennifer Fox | Executive Producer |
| John Sloss | Executive Producer |
| Steven Soderbergh | Executive Producer |
| Denise Chamian | Casting |
| Kari Perkins | Costume Design |
| Darylin Nagy | Makeup Department Head |
| Fred Daniel | Art Department Coordinator |
| Melanie Armstrong Fletcher | Costume Supervisor |
| Brooke Satrazemis | Script Supervisor |
| Tom Hammond | Sound Designer |
| Justin Hennard | Sound Effects Editor |
| Skip Lievsay | Sound Re-Recording Mixer |
| Jeremy Peirson | Sound Re-Recording Mixer |
| Richard Gordoa | Visual Effects Supervisor |
| Sterling Allen | Lead Animator |
| Jason Archer | Head of Animation |
| Evan Cagle | Lead Animator |
| Nick Derington | Lead Animator |
| Sara Johnson | Associate Producer |
| Erin Ferguson | Co-Producer |
| Katina Gilkey | Hairstylist |
| Darylin Nagy | Hair Department Head |
| Susan Kirr | Unit Production Manager |
| Vincent Palmo Jr. | First Assistant Director |
| Andrew Payer | Second Second Assistant Director |
| Kathie Tull | Second Assistant Director |
| Brad Blei | Set Dresser |
| Raymond Consing | Storyboard Artist |
| Melanie Ferguson | On Set Dresser |
| Erick Garibay | Assistant Property Master |
| Ian Sebastian Kasnoff | Construction Coordinator |
| Stefan Wilcox | Property Master |
| Ethan Andrus | Production Sound Mixer |
| Gregg Barbanell | Foley Artist |
| Ajae Clearway | ADR Editor |
| Ajae Clearway | Dialogue Editor |
| Tom Hammond | Supervising Sound Editor |
| Thomas J. O'Connell | ADR Mixer |
| Jason Piatt | Foley Mixer |
| Tom Sturgis | Boom Operator |
| Michael Swanner | Utility Sound |
| Peter Germansen | Sound Engineer |
| Steve Krieger | Special Effects Coordinator |
| Tod Campbell | Loader |
| Matt Cowan | Best Boy Grip |
| Matt Lankes | Still Photographer |
| Mike Reyes | Grip |
| Robert B. Reynolds | Chief Lighting Technician |
| Peter Simonite | First Assistant Camera |
| Josh Taylor | Assistant Chief Lighting Technician |
| Aaron Atom Vyvial | Key Grip |
| Ralph Watson | Camera Operator |
| Scout Masterson | Casting Associate |
| Beth Sepko | Local Casting |
| Christopher Roldan | First Assistant Editor |
| Peter Atherton | Location Manager |
| Dustin Weaver | Assistant Location Manager |
| Bruce Colson | Musician |
| Nic Ratner | Music Supervisor |
| Ronald D. Chambers | Transportation Coordinator |
| Jesus F. Tellez | Transportation Captain |
| Shannon Blackburn | Production Secretary |
| Dominic Cancilla | Production Coordinator |
| Gil Dean | Animal Wrangler |
| Lisa Del Dotto | Assistant Craft Service |
| Michael P. Garza | Title Designer |
| Melody Lloyd | Set Medic |
| Morgan Miles | Production Accountant |
| Tracey Schaefer | Unit Publicist |
