 | Nicolas Cage als Charlie Kaufman / Donald Kaufman |
 | Meryl Streep als Susan Orlean |
 | Chris Cooper als John Laroche |
 | Tilda Swinton als Valerie Thomas |
 | Jay Tavare als Matthew Osceola |
 | Litefoot als Russell |
 | Roger Willie als Randy |
 | Jim Beaver als Ranger Tony |
 | Cara Seymour als Amelia Kavan |
 | Doug Jones als Augustus Margary |
 | Gary Farmer als Buster Baxley |
 | Peter Jason als Defense Attorney |
 | Gregory Itzin als Prosecutor |
 | Curtis Hanson als Orlean's Husband |
 | Agnes NaDene Baddoo als Orlean Dinner Guest |
| Paul Fortune als Orlean Dinner Guest |
| Paul Jasmin als Orlean Dinner Guest |
 | Lisa Love als Orlean Dinner Guest |
| Wendy Mogel als Orlean Dinner Guest |
 | David O. Russell als Orlean Dinner Guest |
 | Judy Greer als Alice the Waitress |
 | Maggie Gyllenhaal als Caroline Cunningham |
 | Bob Stephenson als David |
 | Bob Yerkes als Charles Darwin |
| Lynn Court als Laroche’s Dad |
| Roger E. Fanter als Laroche’s Uncle |
 | Sandra Lee Gimpel als Laroche’s Mom |
| Caron Colvett als Laroche’s Wife |
| Larry Krask als EMT |
 | Ron Livingston als Marty Bowen |
 | Brian Cox als Robert McKee |
| John Etter als McKee Lecture Attendee |
| Ray Berrios als Police Officer |
 | Nancy Lenehan als Kaufman’s Mother |
 | John Cusack als Self (uncredited) |
 | Catherine Keener als Self (uncredited) |
 | John Malkovich als Self (uncredited) |
 | Curt Clendenin als Restaurant Customer (uncredited) |
 | Donald Dowd als Cafe Customer (uncredited) |
| Jonathan Demme | Producer |
| Charlie Kaufman | Screenplay |
| Lance Acord | Director of Photography |
| K.K. Barrett | Production Design |
| Gene Serdena | Set Decoration |
| Spike Jonze | Director |
| Edward Saxon | Producer |
| Casey Storm | Costume Design |
| Peter Andrus | Art Direction |
| Vincent Landay | Producer |
| Justine Arteta | Casting |
| Eric Zumbrunnen | Editor |
| Charlie Kaufman | Executive Producer |
| Carter Burwell | Original Music Composer |
| Kim Davis-Wagner | Casting |
| Peter Saraf | Executive Producer |
| Michael Kirchberger | Supervising Sound Editor |
| Lora Hirschberg | Sound Re-Recording Mixer |
| Kent Sparling | Sound Re-Recording Mixer |
| Richard Beggs | Sound Designer |
| David Abrahamsen | Sound Designer |
| Mark Weber | Sound Mixer |
| Derek Vanderhorst | Sound Mixer |
| Peter Staubli | Sound Effects Editor |
| Marco Kyris | Stand In |
| Julie Janney | Stand In |
| Dan Bradley | Stunt Coordinator |
| Scott Rogers | Stunts |
| Rick Barker | Stunts |
| Chris Carnel | Stunts |
| Lane Leavitt | Stunts |
| Norb Phillips | Stunts |
| Darrin Prescott | Stunts |
| Eddie Yansick | Stunts |
| Karen Koch | Unit Production Manager |
| Thomas Patrick Smith | First Assistant Director |
| Brian O'Kelley | Second Assistant Director |
| Ann Roth | Wardrobe Designer |
| Chiemi Karasawa | Script Supervisor |
| Thomas Lohmann | Camera Operator |
| Mark Williams | First Assistant Camera |
| Jamie Felz | First Assistant Camera |
| Nina Chien | Second Assistant Camera |
| Paul Taylor | Steadicam Operator |
| Mike Pickel | Video Assist Operator |
| Joel Harlow | Makeup Department Head |
| Roz Music | Hair Department Head |
| Stacy Horn | Wardrobe Supervisor |
| Shari Gray | Wardrobe Supervisor |
| Anita Louise Brown | Costumer |
| Marina Marit | Costumer |
| Debbie Travis | Costumer |
| Lynn Barber | Makeup Artist |
| Isabel Harkins | Makeup Artist |
| Allen Weisinger | Makeup Artist |
| J. Roy Helland | Makeup & Hair |
| Joseph Coscia | Hairstylist |
| Larry Waggoner | Hairstylist |
| Michael S. Adler | Chief Lighting Technician |
| Chris Weigand | Assistant Chief Lighting Technician |
| Gino Nix | Key Grip |
| Zoli Hajdu | Dolly Grip |
| Danny Andersen | Dolly Grip |
| Drew Kunin | Production Sound Mixer |
| Lawrence L. Commans | Boom Operator |
| Mark Fay | Boom Operator |
| Gary D'Amico | Special Effects |
| Richard Schuler | Location Manager |
| Gray Marshall | Visual Effects Supervisor |
| Andrew J. Sacks | Production Supervisor |
| Rick C. Taplin | Production Coordinator |
| Seve Spracklen | Production Accountant |
| Chris Forster | Construction Coordinator |
| Anders Rundblad | Construction Foreman |
| Patti McNulty | Art Department Coordinator |
| Lynn Christopher | Set Designer |
| Peter Davidson | Set Designer |
| Grant Samson | Leadman |
| Jeffrey Paul Johnson | Property Master |
| Chris Vail | Assistant Property Master |
| Gregory J. Smith | Second Second Assistant Director |
| Ben Kaller | Still Photographer |
| Stephen Bures | Actor's Assistant |
| Griff Ruggles | Transportation Captain |
| Ronald Stinton | Transportation Co-Captain |
| Dan Bradley | Second Unit Director |
| Eric Osmond | First Assistant Editor |
| Nathan R. Fitzgerald | Assistant Editor |
| David Bach | ADR Editor |
| Bob Fredrickson | Color Timer |
| Jeremy Molod | Assistant Sound Editor |
| Julia Shirar | Assistant Sound Editor |
| Everett Moore | Apprentice Sound Editor |
| David A. Cohen | Dialogue Editor |
| David Franklin Bergad | Dialogue Editor |
| William Storkson | Foley Supervisor |
| Marnie Moore | Foley Artist |
| Nick Peck | Foley Mixer |
| Jory K. Prum | Foley Recordist |
| Adam Milo Smalley | Music Editor |
| Michael Farrow | Scoring Mixer |
| Jonathan Paley | Stand In |
| Susan Orlean | Novel |
| Molly Hansen | Other |
