 | Keke Palmer als Akeelah Anderson |
 | Laurence Fishburne als Dr. Larabee |
 | Angela Bassett als Tanya Anderson |
 | Curtis Armstrong als Mr. Welch |
 | J.R. Villarreal als Javier |
 | Sean Michael Afable als Dylan Chiu |
 | Sahara Garey als Georgia |
 | Lee Thompson Young als Devon |
 | Julito McCullum als Terrence |
 | Erica Hubbard als Kiana |
 | Eddie Steeples als Derrick-T |
 | Dalia Phillips als Ms. Cross |
 | Tzi Ma als Mr. Chiu |
 | Jeris Poindexter als Steve |
| Sara Niemietz als Polly |
| George Hornedo als Roman |
 | Craig Wasson als Ted Saunders |
 | Jeff Marlow als District Judge |
 | Lee Garlington als Regional Judge |
| Katie Kerwin McCrimmon als Herself |
 | Sidney Ganis als Regional Pronouncer |
| Austin Herrera Davis als Cheating Boy |
| Janet Borrus als Cheating Boy's Mom |
 | Wolfgang Bodison als Akeelah's Father |
 | Bonita Friedericy als Volunteer |
 | Lauren Sánchez als Reporter |
 | Fay Hauser als Woman on TV |
 | Jack Ong als Korean Grocer |
| Neil Soni als Rajeev Subramonian |
 | Tinashe als Cissi |
| Doug Atchison | Writer |
| Doug Atchison | Director |
| Glenn Farr | Editor |
| Aisha Coley | Casting |
| Nancy Hult Ganis | Producer |
| Saeed Adyani | Still Photographer |
| M. David Mullen | Director of Photography |
| Jaki Brown | Casting |
| Kim Taylor-Coleman | Casting |
| Aaron Zigman | Original Music Composer |
| Matthew Nicolay | Sound mixer |
| Warren Alan Young | Production Design |
| Julieann Getman | Set Decoration |
| Shelley A. Wallace | Art Direction |
| Edna Sheen | Makeup Department Head |
| Kenneth Walker | Hair Department Head |
| Jennifer Booth | Production Supervisor |
| Joel C. High | Music Supervisor |
| Johnny Caruso | Music Editor |
| Eduardo Ponsdomenech | Music Editor |
| Riki Lin Sabusawa | Costume Supervisor |
| Johnny Radzik | Camera Operator |
| Chris Mosio | Camera Operator |
| Ken S. Polk | Sound Re-Recording Mixer |
| Roland N. Thai | Supervising Sound Editor |
| Roland N. Thai | Sound Designer |
| Stacey A. Washer | Boom Operator |
| Angel DeSanti | Transportation Captain |
| Kirk Huston | Transportation Captain |
| James Morioka | Dialogue Editor |
| Laurence Fishburne | Producer |
| Danny Llewelyn | Producer |
| Mike Upton | Co-Producer |
| Kent Kubena | Co-Producer |
| Sharen Davis | Costume Design |
| Linda Cowan | Key Makeup Artist |
| Gigi Williams | Key Makeup Artist |
| Carl Pedregal | Post Production Supervisor |
| Rodney Allen Hooks | Assistant Director |
| Kathleen Kasinger | Property Master |
| Jason Dock Harrell | Propmaker |
| Matt Furginson | Assistant Property Master |
| Alicia Maccarone | Set Designer |
| Robert 'Cass' McEntee | Construction Coordinator |
| Oswaldo Rojas | Propmaker |
| Greg Sanger | Leadman |
| Melissa Kennelly | Foley Editor |
| Shawn Kennelly | Foley Mixer |
| Laura Macias | Foley Artist |
| Barbara McCart | Sound Recordist |
| James Morioka | Supervising Dialogue Editor |
| Chris Navarro | ADR Recordist |
| Vince Nicastro | Foley Artist |
| Fred Stafford | Supervising ADR Editor |
| Eric Thompson | ADR Mixer |
| James 'Keeper' Auld | Dolly Grip |
| Brad Heiner | Key Grip |
| Marcos O. Lopez | Second Assistant "B" Camera |
| Chris Mosio | Second Unit Director of Photography |
| David Mun | Second Assistant Camera |
| Rich Paisley | Gaffer |
| William Rick Young | Best Boy Grip |
| Markus Czyzewski | First Assistant Editor |
| Jan McWilliams | Script Supervisor |
| Jules Carideo | Production Coordinator |
| Heather Fielding | Studio Teacher |
| Kevin Moll | Studio Teacher |
| Jo Ann Smith | Studio Teacher |
| Mark Cuban | Executive Producer |
| Cheryl Cravedi | Set Costumer |
