 | Tyler Perry als Dr. Alex Cross |
 | Edward Burns als Tommy Kane |
 | Matthew Fox als Picasso |
 | Rachel Nichols als Monica Ashe |
 | Carmen Ejogo als Maria Cross |
 | Jean Reno als Leon Mercier |
 | John C. McGinley als Richard Brookwell |
 | Giancarlo Esposito als Daramus Holiday |
 | Cicely Tyson als Nana Mama |
 | Chad Lindberg als Vincent Dardis |
 | Stephanie Jacobsen als Fan Yau |
 | Sonny Surowiec als Hans Friedlich |
 | Yara Shahidi als Janelle Cross |
 | Gary A. Jones als Funeral Guest (uncredited) |
 | Simon Rhee als Fan Yau Bodyguard #3 |
 | Alexandra Ruddy |
| Rob Cohen | Director |
| Marc Moss | Screenplay |
| Kerry Williamson | Screenplay |
| James Patterson | Novel |
| Bill Block | Producer |
| Steve Bocsi | Executive Producer |
| Steve Bowen | Producer |
| Remington Chase | Executive Producer |
| Randall Emmett | Producer |
| George Furla | Executive Producer |
| Ronna Kress | Casting |
| Matt Diezel | Editor |
| Thom Noble | Editor |
| Laura Fox | Production Design |
| Charles Varga | Art Direction |
| Gabriella Villarreal | Set Decoration |
| Kimberly Jones | Makeup Department Head |
| Wendy M. Craig | Costume Supervisor |
| Paul Hanson | Producer |
| Ethan Smith | Executive Producer |
| John Friedberg | Executive Producer |
| Jeff Rice | Executive Producer |
| Stepan Martirosyan | Executive Producer |
| James Patterson | Producer |
| Leopoldo Gout | Producer |
| John Debney | Original Music Composer |
| Diane Durant | Script Supervisor |
| Ricardo Della Rosa | Director of Photography |
| Dayna Polehanki | Casting Associate |
| Willie D. Burton | Production Sound Mixer |
| Mike Watts | Orchestrator |
| Hilary Bristoll | Art Department Coordinator |
| Sue Brook | Carpenter |
| Joseph Waterkotte | Construction Coordinator |
| Paul Peabody | Construction Coordinator |
| Brent Peelor | Construction Foreman |
| Kenneth Stanley | Construction Foreman |
| Louis P. Taylor | Construction Foreman |
| Jim Butler | Construction Foreman |
| John S. Bukala | Construction Foreman |
| Christopher Hosey | Graphic Designer |
| Phil Shirey | Leadman |
| Brent Wachter | Painter |
| Ritchie Kremer | Property Master |
| Curtis Corbitt | Property Master |
| Justin N. Lang | Set Designer |
| Kurt Braun | Set Dresser |
| Ellie H. Ferrari | Set Dresser |
| Leyna Haller | Set Dresser |
| Keith Allan Miller | Set Dresser |
| Andy Schofield | Set Dresser |
| Donna Williams | Set Dresser |
| Todd Harris | Storyboard Artist |
| Bob Bouwman | Swing |
| Nick Cutway | Additional Second Assistant Camera |
| Dan Jarrell | Best Boy Grip |
| Jule Fontana | Camera Loader |
| John S. Moyer | Camera Operator |
| Michael Mansouri | Digital Imaging Technician |
| Ralph Scherer | Dolly Grip |
| Kelly R. Borisy | Dolly Grip |
| Kevin Coyne | Electrician |
| Jake Hossfeld | Electrician |
| Julie 'Doc' Lindstrom | Electrician |
| Chris McLeod | Electrician |
| Ted Nimz | Electrician |
| Donnie Schneider | Electrician |
| Scott Schuerger | Electrician |
| John Turk | Electrician |
| Michael Dzialowski | First Assistant Camera |
| Gregg Horvath | First Assistant Camera |
| Mariana Sánchez de Antuñano | First Assistant "A" Camera |
| Andy Hoehn | First Assistant Camera |
| Phil Walker | Gaffer |
| Anthony T. Marra II | Key Grip |
| William MacLeod | Key Grip |
| Anthony 'Spike' Simms | Rigging Gaffer |
| Mike Dittiacur | Rigging Grip |
| Josh Ficken | Rigging Grip |
| John Vinson | Rigging Grip |
| Paul Schilens | Second Assistant Camera |
| Dino Parks | Second Unit Director of Photography |
| Mark Karavite | Steadicam Operator |
| Bela Trutz | Steadicam Operator |
| Craig Nix | Techno Crane Operator |
| Mark N. Woods | Techno Crane Operator |
| Catherine Riley | Assistant Costume Designer |
| Sabra Temple | Costumer |
| Kate Abraham | Costumer |
| Queensylvia Akuchie | Costumer |
| Jordan Carper | Set Costumer |
| Gina Nalli | Set Costumer |
| Lauren Legate | Wardrobe Assistant |
| Natasha Rivera | Wardrobe Assistant |
| Noa Franco | Casting Assistant |
| Katy Russell | Casting Assistant |
| Leslie Woo | Casting Associate |
| Dayna Polehanki | Local Casting |
| Russell Tyrrell | Special Effects Coordinator |
| Mike S. Huffman | Special Effects Technician |
| Nicholas Leone | Special Effects Technician |
| David Scheper | Special Effects Technician |
| Gary Strobel | Special Effects Technician |
| Raymond M. Tasillo | Special Effects Technician |
| Pipin Supinah | Assistant Hairstylist |
| Shannon Bakeman | Hair Department Head |
| Pierce Austin | Hairstylist |
| Stacey Morris | Hairstylist |
| Kevin J. Edwards | Key Hair Stylist |
| Widya Rusnaeni | Makeup & Hair |
| Amber Crowe | Key Makeup Artist |
| Wanda Patterson | Makeup Artist |
| Gary A. Jones | Stunt Driver |
| Martin L. Mercer | Storyboard Artist |
| Laura Albert | Stunts |
| Jeffrey G. Barnett | Stunts |
| Abigail Murray | Costume Designer |
| Christopher J. Corabi | Executive Producer |
| Marina Grasic | Executive Producer |
| Jan Korbelin | Executive Producer |
