 | Colin Farrell als Alexander |
 | Angelina Jolie als Olympias |
 | Val Kilmer als Philip |
 | Jared Leto als Hephaistion |
 | Jonathan Rhys Meyers als Cassander |
 | Anthony Hopkins als Old Ptolemy |
 | Jessie Kamm als Child Alexander |
 | Christopher Plummer als Aristotle |
 | Connor Paolo als Young Alexander |
| Patrick Carroll als Young Hephaistion |
| Peter Williamson als Young Nearchus |
| Morgan Christopher Ferris als Young Cassander |
 | Rob Earley als Young Ptolemy |
 | Aleczander Gordon als Young Perdiccas |
 | John Kavanagh als Parmenion |
 | Gary Stretch als Cleitus |
 | Rosario Dawson als Roxane |
 | Toby Kebbell als Pausanius |
 | Fiona O'Shaughnessy als Nurse |
 | Laird Macintosh als Greek Officer |
 | Francisco Bosch als Bagoas |
 | Neil Jackson als Perdiccas |
 | Rory McCann als Crateros |
 | Raz Degan als Darius III |
 | Joseph Morgan als Philotas |
 | David Bedella als Scribe |
 | Brian Blessed als Wrestling Trainer |
 | Nick Dunning als Attalus |
 | Elliot Cowan als Ptolemy |
 | Ian Beattie als Antigonus |
 | Denis Conway als Nearchus |
 | Michael Dixon als Campfire Soldier |
 | Tim Pigott-Smith als Omen Reader |
 | Erol Sander als Persian Prince |
 | Stéphane Ferrara als Bactrian Commander |
 | Tadhg Murphy als Dying Soldier |
 | Annelise Hesme als Stateira |
 | Marie Meyer als Eurydice |
| Mick Lally als Horse Seller |
 | Garrett Lombard als Leonnatus |
| Chris Aberdein als Polyperchon |
| Jean Le Duc als Fat Eunuch |
| Mohammed Tsouli als Persian Chamberlain |
 | Rab Affleck als Attalus' Henchman |
 | Féodor Atkine als Roxane's Father |
| Harry Kent als Cup Bearer #1 |
| Sam Green als Cup Bearer #2 |
 | Bin Bunluerit als Indian King |
| Jaran Ngamdee als Indian Prince |
 | Brian McGrath als Doctor |
| Suzanne Bullock als Roxane Dancer |
| Kate Eloise Whitfield als Roxane Dancer |
| Gillian Grueber als Roxane Dancer |
 | Michelle Lukes als Roxane Dancer |
| Anjali Mehra als Roxane Dancer |
| Anthony Jean Marie Kurt als Bagoas Dancer |
| Marta Barahona als Bagoas Dancer |
| Monica Zamora als Bagoas Dancer |
 | Benny Maslov als Bagoas Dancer |
| Tania Matos als Bagoas Dancer |
| Leighton Morrison als Bagoas Dancer |
| Isaac Mullins als Bagoas Dancer |
| Monica Perego als Bagoas Dancer |
| Matthew Powell als Bagoas Dancer |
 | Benjamín Benítez als Amato (uncredited) |
| Anthony James Berowne als Greek Courtier (uncredited) |
 | Nicolas D. Blake als Palace Page (uncredited) |
 | Max Bollinger als Young Greek Official (uncredited) |
 | Jason Croot als Peasant (uncredited) |
 | Dale Dye als Macedonian Veteran at Hyphasis Speech (uncredited) |
| Fahar Faizaan als Voiceover - Alexander (uncredited) |
| Charles Haigh als Aristander (uncredited) |
 | Abbie Hirst als Octavia (uncredited) |
| Charlie Hollway als Boy (uncredited) |
| Rowley Irlam als Pausanius's Accomplice (uncredited) |
 | David Leon als Hermolaous (uncredited) |
| Evelina Manna als Apparition (uncredited) |
| Desmond O'Neill als Acolyte at Sacrifice (uncredited) |
 | Greg Orvis als Celtic Diplomat (uncredited) |
| Lee Anthony Parnell als Warrior (uncredited) |
 | John Reynolds als Dexapous (uncredited) |
| Peter Rnic als Greek Nobleman (uncredited) |
 | Oliver Stone als Macedonian Soldier at Zeus Statue (uncredited) |
 | John Whitby als Horse Rider (uncredited) |
| Suzanne Crowley | Casting |
| Iain Smith | Producer |
| Lucinda Syson | Casting |
| Kevin Phipps | Art Direction |
| Sarah Bradshaw | Unit Production Manager |
| Rodrigo Prieto | Director of Photography |
| Vangelis | Original Music Composer |
| Vangelis | Music Arranger |
| Oliver Stone | Screenplay |
| Oliver Stone | Director |
| Oliver Stone | Producer |
| Thomas Schühly | Producer |
| Billy Hopkins | Casting |
| Dale Dye | Second Unit Director |
| Jon Kilik | Producer |
| Kerry Barden | Casting |
| Jim Erickson | Set Decoration |
| Winston Azzopardi | Location Scout |
| Jean-Paul Mugel | Production Sound Mixer |
| Bruno Tarrière | Sound Re-Recording Mixer |
| Norman Baillie | Prosthetic Makeup Artist |
| Jeremy Woodhead | Makeup Designer |
| Gianni Nunnari | Co-Executive Producer |
| Pierre Grunstein | Executive Producer |
| Hans de Weers | Co-Producer |
| Juliette Ménager | Local Casting |
| Jenny Beavan | Costume Design |
| Laeta Kalogridis | Screenplay |
| Jonathan McKinstry | Supervising Art Director |
| Paul Rassam | Executive Producer |
| Jan Roelfs | Production Design |
| Christopher Kyle | Screenplay |
| Moritz Borman | Producer |
| Yann Hervé | Editor |
| Thomas J. Nordberg | Editor |
| Gladys Joujou | Editor |
| Alex Márquez | Editor |
| Léonard Glowinski | Associate Producer |
| Stuart Rose | Art Direction |
| Jean Goudier | Supervising Sound Editor |
| Adil Abdelwahab | Assistant Location Manager |
| Desmond Crowe | Art Direction |
| Berto | Additional Camera |
| Dan Maag | Production Executive |
| Peter Gleaves | ADR Mixer |
| Lek Chaiyan Chunsuttiwat | Art Direction |
| Mark Bennett | Casting |
| Frederic Evard | Assistant Art Director |
| Dave Bonneywell | Special Effects Supervisor |
| Matthias Deyle | Executive Producer |
| Fernando Sulichin | Co-Executive Producer |
| David Allday | Visual Effects Art Director |
| Budd Carr | Music Supervisor |
| Tabrez Noorani | Producer |
| Pravesh Sahni | Line Producer |
| Colin Jamison | Hairdresser |
| Rosemary Burrows | Costume Supervisor |
| Colin Jackman | Sculptor |
| Julien Perez | Sound Recordist |
| Chris David | Sound Re-Recording Mixer |
| François Lepeuple | Foley Artist |
| Nic Raine | Orchestrator |
| Nic Raine | Conductor |
| Volker Schauz | Executive Producer |
| Danny Hiele | Additional Photography |
| Mari-An Ceo | Assistant Costume Designer |
| Aslan Nadery | Executive Producer |
| Lizz Wolf | Key Costumer |
| Stéphane Cressend | Art Direction |
| Jean Hemez | Animation |
| George Richmond | Camera Operator |
| George Richmond | Steadicam Operator |
| James Lewis | Art Direction |
| Santa Pestonji | Producer |
| Robert S. Wilson | Associate Producer |
| Enfys Dickinson | Creative Producer |
| Olivier Chiavassa | Digital Intermediate |
| Anthony Leonardi III | Costume Illustrator |
| Stephen Miles | Assistant Costume Designer |
| Dulcie Scott | Costume Coordinator |
| Stephane Ceretti | Visual Effects Supervisor |
| Nicolas Aithadi | CG Supervisor |
| Kathleen Lorden | Art Direction |
| Kathleen Lorden | Researcher |
| Rebecca Roper | Local Casting |
| Claudio Campana | Assistant Art Director |
| Katie Gabriel | Art Department Coordinator |
| Emma Hanson | Sculptor |
| Arthur Dunne | Transportation Coordinator |
| Wylie Stateman | Supervising Sound Editor |
| Katia Boutin | Supervising Dialogue Editor |
| Vincent Cosson | Sound Assistant |
| Christian Huband | Assistant Art Director |
| Kurt Smith | Color Timer |
| Julie Brown | Script Supervisor |
| Rowley Irlam | Stunt Double |
| Will Kaplan | Music Editor |
| John Gamble | First Assistant Camera |
| Catherine Charlton | Dialogue Coach |
| Tom Still | Assistant Art Director |
| Jaap Buitendijk | Still Photographer |
| Lotta Wolgers | Set Designer |
| Youssef Abagourram | Construction Coordinator |
| Abdellah Baadil | Assistant Art Director |
| Aziz Hamichi | Assistant Art Director |
| David Balfour | Property Master |
| Tommy Jolliffe | Scenic Artist |
| Nicky Kaill | Scenic Artist |
| Andy Evans | Construction Coordinator |
| Ian Whiteford | Greensman |
| Mohamed Rakaa | Leadman |
| Gréggory Poncelet | Sound Recordist |
| Anne Delacour | Dialogue Editor |
| André Dias | ADR & Dubbing |
| Alain Féat | Dialogue Editor |
| Alek Goosse | Sound Re-Recording Mixer |
| Aurelia Abate | Visual Effects Producer |
| Joyce Menger | Visual Effects Producer |
| Kilou Picard | Visual Effects Producer |
| Andy Stevens | Visual Effects Editor |
| John Scheele | Visual Effects Supervisor |
| Elliott Jobe | Visual Effects Supervisor |
| Rudi Holzapfel | Visual Effects Supervisor |
| Sébastien Drouin | Visual Effects Supervisor |
| Gary Powell | Stunt Coordinator |
| Ian Foster | Camera Operator |
| John Higgins | Gaffer |
| Hicham Regragui | Transportation Coordinator |
| Piers Gielgud | Choreographer |
| Deborah Maxwell Dion | Casting Associate |
| Ken Yasumoto | Sound Effects Designer |
| Michael Singer | Publicist |
| Majid Aoulad Abdellah | Assistant Unit Manager |
| John Marzano | Helicopter Camera |
| John Marzano | Aerial Director of Photography |
| Jonathan 'Chunky' Richmond | First Assistant Camera |
| David Sinfield | Electrician |
| Ben Wilson | First Assistant Camera |
| Gary Dawson | Dressing Prop |
| Kevin Edland | Best Boy Electric |
| Wayne Leach | Rigging Gaffer |
| Andy Taylor | Visual Effects Coordinator |
| Chas Bain | Focus Puller |
| Paula Price | Makeup Artist |
| Sue Field | Script Supervisor |
| Tim Pounds-Cornish | Visual Effects Editor |
| Brendan Handscombe | Wardrobe Assistant |
| Jonathan Hook | Unit Manager |
| Jonathan Taylor | Second Unit Director of Photography |
| Nicolas Bonnell | Production Supervisor |
| Paul Conway | Supervising ADR Editor |
| Jean-Claude Deguara | Animation |
| Stephanie Hovette | Wigmaker |
| Zoe Clare Brown | Hairstylist |
| Sean Connor | Focus Puller |
| Sean Button | Stunts |
| Capucine Courau | Assistant Dialogue Editor |
| Martin Asbury | Storyboard Artist |
| Benjamin Darras | Visual Effects Production Assistant |
| Karim Abouobayd | Production Manager |
| Driss Marzak | Electrician |
| Jan Archibald | Hair Designer |
| Barbara Taylor | Key Hair Stylist |
| Deborah Jarvis | Makeup Artist |
| Rebecca Cole | Makeup Artist |
| Olivier Pron | Animation Supervisor |
| Richard Hooper | Supervising Armorer |
| Trevor Wood | Special Effects Supervisor |
| Carl Isherwood | Driver |
| Yvan Lucas | Colorist |
| Rachid Aadassi | Costume Assistant |
| Steve Costello | Gaffer |
| Séverine De Wever | Visual Effects Coordinator |
| Emmanuelle Carlier | Visual Effects Coordinator |
| Helen Chapman | Set Runner |
| Iain Eyre | ADR Editor |
| Marc Wolff | Pilot |
| Sam Barnes | Clapper Loader |
| Chaz Lyon | Assistant Camera |
| Alexander Beddow | ADR Recordist |
| Larry Gooch | Painter |
| Julian Caldow | Conceptual Illustrator |
| Philippe Soeiro | Title Designer |
| Kamaleddine Talmi | Grip |
| Mustapha Ismaili Alaoui | Transportation Captain |
| Damien Lazzerini | Sound Recordist |
| Rich Lee | Pre-Visualization Supervisor |
| Mutita Na Songkla | Wardrobe Supervisor |
| Karine Binaux | Visual Effects Coordinator |
| Michael Maker | Associate Producer |
| Saida Elidrissi | Art Department Assistant |
| Olivier Fortin | First Assistant Camera |
| Malcolm Huse | Key Grip |
| Mustapha Haouas | Set Dressing Artist |
| Warren Lever | Carpenter |
| Cyril Contejean | Post Production Supervisor |
| Wesley Peppiatt | Propmaker |
| Phattana Sansumran | Set Production Assistant |
| Boris Dores | Software Engineer |
| David House | Stand In |
| Paul Hornsby | Utility Stunts |
| Simon Warnock | Assistant Director |
| Eugene Grobler | Electrician |
| Paul Kelly | Lighting Technician |
| Kurt P. Galvao | Executive In Charge Of Production |
| Said Andam | Location Manager |
| Sarah Trowse | Production Accountant |
| Mona Benjamin | Production Coordinator |
| Samuel Cohen | Boom Operator |
| Julien Bourdeau | Assistant Sound Editor |
| Frédéric Attal | Sound Editor |
| Lucie Bories | Digital Compositors |
| Pierre Michel-Estival | Visual Effects |
| Laetitia Beaujard | Visual Effects Coordinator |
| Tom Carrick | Motion Capture Artist |
| Nourdine Zaoui | Sound |
| Warwick Drucker | Additional Grip |
| Charlie England | Assistant Camera |
| Louis Elman | ADR Voice Casting |
| Rene Adefarasin | Assistant Camera |
| W.C. 'Chunky' Huse | Key Grip |
| Rebecca Gatrell | Music Coordinator |
| Ron Frankel | Pre-Visualization Supervisor |
| Yann Mari Faget | Second Assistant Director |
| Robert Allen | Construction Buyer |
| Garth Sewell | Grip |
| Sana El Kilali | Accountant |
| Gill Raddings | Animal Coordinator |
| Georgia Scheele | Visual Effects Coordinator |
| Éric Bonnard | Foley Mixer |
| Aziz Bousfiha | Assistant Accountant |
| Mohamed Achaour | Third Assistant Director |
| Sam Phillips | Grip |
| Kat Szuminska | Compositing Supervisor |
| Max Glickman | Assistant Camera |
| Jemma Scott-Knox-Gore | Contact Lens Technician |
| Chesda 'Pop' Smithsuth | Gaffer |
| Rangsun Rangsimaporn | Special Effects Supervisor |
| Paul Holley | Generator Operator |
| David Churchyard | Camera Trainee |
| Adam Lee | Electrician |
| Gary Smith | Grip |
| Alistair Anderson | Special Effects Technician |
| Dean Morris | Assistant Camera |
| Tim Dean | Libra Head Technician |
| Charlie Woodburn | First Assistant Camera |
| Hassan Iken | Costumer |
| Michael Elson | Head of Production |
| Paul Tsan | Grip |
| Andrew Baggarley | Data Wrangler |
| Rachid Mssiaidi | Grip |
| Iain Lawrence | Second Second Assistant Director |
| Matt Lopez-Dias | Daily Grip |
| Heidi Gibb | Draughtsman |
| Adrian Borg Ghigo | Camera Car |
| Piyanit Amphawat | Casting Assistant |
| Aurélie Bensoussan | Assistant Editor |
| Mike Thomas | Editorial Consultant |
| Suzanne Gilbert | Post Production Coordinator |
| Smart Sumalee | Animal Wrangler |
| Phyl Allarie | Assistant Production Coordinator |
| Arnaud Pecqueur | Matte Painter |
| Hassan Aridal | Production Assistant |
| Matthew Lee | Production Runner |
| Dave Bonneywell | Special Effects Supervisor |
| Danielle Costa | Visual Effects Coordinator |
| Anabelle Boudineau | Animation |
| Tatiana Makogon | Animation |
| Ekkarat Rodthong | Animation |
| Matthew Rappaport | Compositor |
| Daniel Szeto | Compositor |
| Sarah Moreau | Visual Effects Coordinator |
| Ian Murray | Visual Effects Coordinator |
| Caroline Rivière | Visual Effects Coordinator |
| Gregory Tournier | Visual Effects Coordinator |
| Stefan Lange | VFX Director of Photography |
| Moulay Mustapha El Idrissi | Grip |
| Mustapha Steila | Special Effects Supervisor |
| Sarah Shepherd | Textile Artist |
