 | Charlie Sheen als Charlie B. Barkin (voice) |
 | Dom DeLuise als Itchy Itchiford (voice) |
 | Adam Wylie als David (voice) |
 | Sheena Easton als Sasha La Fleur (voice) |
 | Ernest Borgnine als Carface (voice) |
 | George Hearn als Red (voice) |
 | Bebe Neuwirth als Anabelle (voice) |
 | Hamilton Camp als Chihuahua (voice) |
 | Steve Mackall als Short Customs Dog (voice) |
 | Dan Castellaneta als Tall Customs Dog / Angel Dog #1 (voice) |
 | Tony Jay als Reginald (voice) |
 | Jim Cummings als Jingles (voice) |
 | Wallace Shawn als Labrador MC (voice) |
 | Kevin Michael Richardson als St. Bernard / Officer Andrews (voice) |
 | Pat Corley als Officer McDowell (voice) |
 | Maurice LaMarche als Lost & Found Officer (voice) |
| Larry Leker | Director |
| Paul Sabella | Director |
| Caroline Cruikshank | Animation |
| John Williamson | Animation Director |
| Gary S. Gerlich | Supervising Sound Editor |
| Elliott Koretz | Supervising Sound Editor |
| Paul Massey | Sound Re-Recording Mixer |
| Chris David | Sound Re-Recording Mixer |
| Maria Estrada | Casting |
| Mark Watters | Original Music Composer |
| Tony Garber | Editor |
| Dominick Certo | Music Editor |
| Kelly Ward | Story |
| Kelly Ward | Screenplay |
| Mark Young | Story |
| Mark Young | Screenplay |
| Arne Olsen | Screenplay |
| Barry Mann | Songs |
| Cynthia Weil | Songs |
| Deane Taylor | Art Direction |
