 | Dylan O'Brien als Mitch Rapp |
 | Michael Keaton als Stan Hurley |
 | Taylor Kitsch als 'Ghost' |
 | Shiva Negar als Annika |
 | Sanaa Lathan als Irene Kennedy |
 | Scott Adkins als Victor |
 | David Suchet als Director Stansfield |
 | Navid Negahban als Minister Behurz |
 | Joseph Long als General Rostami |
 | Charlotte Vega als Katrina |
 | Andrew Pleavin als Admiral Bristow |
 | Shahid Ahmed als Adnan Al-Mansur |
 | Joost Janssen als American Operator |
 | Adam Collins als American Operator #2, Mansur Compound |
 | Christopher Bomford als Bartender |
 | Stephen Shafer als Blackhawk Pilot |
 | Vladimir Fridman als Borys Bartosh |
 | Nick Cavaliere als Building Superintendent |
| Adam Robertson als Damage Control Officer |
 | Trevor White als Dr. Frain |
 | Josh Danford als CIA Officer #3 |
 | JF Davis als CIA Officer Giving Nuke Intel |
 | Bentley Kalu als Delta One Lead |
 | Sydney White als Emily, Rome Safe House |
| Shani Erez als Female Mossad Agent |
| Martina Brusco als Hotel Concierge |
| Sharif Dorani als Iranian Nuclear Physicist |
 | Alaa Safi als Javeed |
 | Tolga Safer als Kamil, Sharif's Assistant |
 | Bruno Bilotta als Keys |
 | Yousef Sweid als Khaled |
 | Chris Webster als Mansur Recruit Video |
 | Buster Reeves als Martial Arts Instructor |
 | Simon Connolly als NSA Techie |
 | Michael Wildman als Orion Instructor |
| Alexis Barron als Pregnant Woman |
 | Khalid Laith als Sharif |
 | Göksun Çam als Sharif's Mistress |
| Roberto Sgarbi als Stolen Car Owner |
 | Aso Sherabayani als Turkish MP |
 | Nej Adamson als Turkish Operative |
 | Ronan Summers als USS Eisenhower Captain |
 | Matt Rippy als USS Flynn Captain |
| Gjevat Kelmendi als Vladik |
| Damian Dudkiewicz als Warsaw Cop |
| Jake Mann als Ben (uncredited) |
 | Jorge Leon Martinez als CIA Agent (uncredited) |
 | Dacio Caballero als Camorra (uncredited) |
 | Kamil Lemieszewski als Waiter (uncredited) |
 | Kola Bokinni als Destroyer Boson (uncredited) |
 | Garreth Hadfield als Boat Terrorist (uncredited) |
| Alexander Winters als Tourist Victim (uncredited) |
 | Mohammad Bakri als Ashani |
| Michael Cuesta | Director |
| Stephen Schiff | Screenplay |
| Elaine Grainger | Casting |
| Daniel M. Stillman | Executive Producer |
| Lorenzo di Bonaventura | Producer |
| Nick Wechsler | Producer |
| Aidan Elliott | Co-Producer |
| Marco Valerio Pugini | Line Producer |
| Vince Flynn | Novel |
| Justin Warburton-Brown | Art Direction |
| Francesco Alberico | Hair Department Head |
| Tony Browne | Hairstylist |
| Stefano De Nardis | Costume Supervisor |
| Elena Antzon | Script Supervisor |
| Mark Wyndham | Costume Coordinator |
| Dann Fink | ADR Voice Casting |
| Luigi Pini | Boom Operator |
| Felicity Bowring | Makeup Department Head |
| Terry Woods | Property Master |
| Claudette Lilly | Assistant Costume Designer |
| Alexa Zimmerman | Dialogue Editor |
| Lawrence Zipf | Sound Designer |
| Melanie Lenihan | Key Makeup Artist |
| Daryl Bristow | Costume Supervisor |
| Andrea Giannetta | Boom Operator |
| Enrique Chediak | Director of Photography |
| Somm Suthinee Chantakarn | Art Department Coordinator |
| Ian Creed | Marine Coordinator |
| Richard Pilcher | Boom Operator |
| Paul Biddiss | Armorer |
| Alma Magaña | Key Costumer |
| Emma Gunnery | Casting Associate |
| Edward Zwick | Screenplay |
| Roberta Federico | Art Direction |
| Melissa Mazzocco | Makeup Artist |
| Marc Wolff | Aerial Coordinator |
| Peter Paul | Assistant Costume Designer |
| Dave Flynch | Supervising Sound Editor |
| Lek Chaiyan Chunsuttiwat | Art Direction |
| Paula Casarin | Script Supervisor |
| Andrew Laws | Production Design |
| Simone Carlo Toniato Toso | Set Costumer |
| Katie Harlow | Script Supervisor |
| Lee Salevan | Sound Recordist |
| Michael Finch | Screenplay |
| Julia Dehoff | Assistant Art Director |
| Max Brennan | Set Costumer |
| Matthew Gray | Supervising Art Director |
| Marshall Herskovitz | Screenplay |
| Jane Harwood | Art Direction |
| Beverley Crockard | Art Department Coordinator |
| Gianluca Piola | Property Master |
| Wyatt Sprague | Sound Effects Editor |
| Conrad Buff IV | Editor |
| Melanie Lenihan | Key Hair Stylist |
| Chris Seefried | Music Supervisor |
| Stefan Stankowski | Camera Operator |
| Jonathan Spencer | Chief Lighting Technician |
| Marc Wolff | Pilot |
| Becky Roberts | Visual Effects Producer |
| Neil Ashton | Electrician |
| Carl Grinter | Visual Effects Producer |
| Fabio Lucheroni | Gaffer |
| Francesco Zaccaria | Gaffer |
| Tommaso Mele | Key Grip |
| Martin Rossi | Animation |
| Simon Cockren | Special Effects Supervisor |
| Amar Ingreji | Visual Effects Editor |
| Samuel Perkins | Visual Effects Editor |
| Christian Black | Still Photographer |
| William Sheffield | Electrician |
| Sara Pedramnia | Visual Effects Coordinator |
| Phoebe Sutherland | Visual Effects Coordinator |
| Harry Gay | Electrician |
| Oliver Poole | Electrician |
| Farhad Yusufi | 3D Generalist |
| Carlo Postiglione | Dolly Grip |
| Richard R. Reed | Visual Effects Supervisor |
| Oliver Whickman | Electrician |
| Thomas Phillips-Howard | Animation |
| Adam Dale | Aerial Director of Photography |
| Gareth Harfoot | Drone Operator |
| Alessandro Brambilla | Steadicam Operator |
| Gábor Kiss | Animation |
| Jordan Spencer | Lighting Technician |
| Alessandro Bolognesi | Pilot |
| Misako Shimizu | Assistant Editor |
| Giorgio Pezzotti | Key Grip |
| Angus Benson-Blair | Pilot |
| Daniel Rogers | Health and Safety |
| Paul Norris | Visual Effects Supervisor |
| Francesco Alberico | Hair Designer |
| Richard Goodwin | First Assistant Director |
| Kendall Capito | Makeup Artist |
| Steven Murphy | Greensman |
| Steven Price | Original Music Composer |
| Stefano Carbonaro | Leadman |
| Mark Coulier | Prosthetic Designer |
| Jo Grover | Makeup Artist |
| Letizia Santucci | Set Decoration |
| Felicity Bowring | Makeup Designer |
| Ailbhe Lemass | Key Makeup Artist |
| Tom Rye | Second Assistant Director |
| Arwel Evans | Art Direction |
| Anna B. Sheppard | Costume Design |
| Barney Shakespeare | Third Assistant Director |
| Tom Olive | Set Decoration |
| Colum Mangan | Prosthetic Makeup Artist |
| Rachel Jablin | Post Production Supervisor |
| Carly Mason | Graphic Designer |
| Lynn Doron | Makeup & Hair |
| Peter McKinstry | Concept Artist |
| Naomi Moore | Set Decoration |
| Ailbhe Lemass | Key Hair Stylist |
| Gianpaolo Rifino | Supervising Art Director |
| Micah Blaichman | Foley Mixer |
| Chris Navarro | ADR Mixer |
| Jay Peck | Foley Artist |
| Thea Soady | Construction Coordinator |
| Bobby Johanson | ADR Mixer |
| Tommy Holman | First Assistant "C" Camera |
| Andrii Palekha | Drone Cinematographer |
| Calem Trevor | Second Assistant Camera |
| Matthew Savage | Concept Artist |
| Andy Wareham | Stunt Double |
| Jason Martin | Rigging Gaffer |
| Paul Wheeldon | First Assistant Camera |
| Vince Flynn | In Memory Of |
| Michael Feuser | Dialogue Editor |
| Alexis Barron | Stunts |
| Shiraz Yasin | Utility Stunts |
| Kat Spencer | Second Assistant "A" Camera |
| Will Samuelson | Pilot |
| Michael Rivera | ADR Recordist |
| Cristiano Biagioli | Dolly Grip |
| Robert Binnall | Second Unit Director of Photography |
| Pipat Sripradoo | Property Master |
| Hunter Berk | ADR Mixer |
| Eugene Gearty | Sound Designer |
| Angus Benson-Blair | Drone Pilot |
| Bargaje Bharat | Modeling |
| Gareth Harfoot | Aerial Camera |
| Dan Osborne | Supervising Armorer |
| Tobias Eedy | First Assistant "B" Camera |
| Doriano Forti | Rigging Grip |
| Spencer Murray | First Assistant "A" Camera |
| Nishad Shelar | Modeling |
| Casey Michaels | Stunt Double |
| Nick Jeffries | Supervising Armorer |
| Warren Parkinson | Assistant Property Master |
| Paul Urmson | Supervising Sound Editor |
| Skip Lievsay | Supervising Sound Editor |
| Michael Miller | ADR Mixer |
| Jay Joshi | Rotoscoping Artist |
| Emanuele Leurini | First Assistant Camera |
| Brian Tarlecki | Sound Re-Recording Mixer |
| Ian Pead | Stunt Double |
| Marcus Shakesheff | Fight Choreographer |
| Supoj Khaowwong | Stunts |
| Carole A. Kenneally | First Assistant Editor |
| Egidio Iorio | Camera Trainee |
| Timothy Eulich | Stunt Double |
| Jessica Hooker | Stunts |
| Tomasz Krzemieniecki | Stunts |
