 | Will Ferrell als Ron Burgundy |
 | Christina Applegate als Veronica Corningstone |
 | Paul Rudd als Brian Fantana |
 | Steve Carell als Brick Tamland |
 | David Koechner als Champ Kind |
 | Fred Willard als Ed Harken |
 | Chris Parnell als Garth Holliday |
 | Kathryn Hahn als Helen |
 | Fred Armisen als Tino |
 | Seth Rogen als Eager Cameraman |
 | Paul F. Tompkins als MC |
 | Danny Trejo als Bartender |
 | Scot Robinson als Waiter at Tino's |
 | Ian Roberts als Stage Manager |
 | Darcy Donavan als Hot Blonde |
| Renee Weldon als Petite Brunette |
 | Jerry Minor als Tino's Bassist |
 | Holmes Osborne als Director |
 | Charles Walker als Security Guard |
| Thomas E. Mastrolia als Biker Guy |
 | Jay Johnston als Eyewitness News Member |
 | Peter A. Hulne als Man in Kitchen |
 | Laura Kightlinger als Donna |
 | Adam McKay als Custodian |
| Joseph T. Mastrolia als Custodian |
 | Judd Apatow als News Station Employee |
 | Debra McGuire als News Station Employee |
 | Kent Shocknek als Network Reporter |
| Monique McIntyre als Yelling Woman |
| Bob Rummler als Bum |
| Chuck Poynter als Announcer |
| Esmerelda McQuillan als Middle Class Mother |
| Angela Grillo als Elderly Woman |
| Lionel Allen als Wealthy Family Father |
| Trina D. Johnson als Wealthy Family Mother |
| Fred Dresch als Doctor |
| Glen Hambly als Middle Class Dad |
| Stuart Gold als Nursing Room Resident |
 | Bill Kurtis als Bill Lawson - Narrator (voice) |
 | Jack Black als Motorcyclist |
 | Ben Stiller als Arturo Mendes |
 | Luke Wilson als Frank Vitchard |
| Frank Gorgie als Frank the Bartender (uncredited) |
 | Missi Pyle als Zoo Keeper (uncredited) |
 | Tim Robbins als Public TV News Anchor (uncredited) |
 | Vince Vaughn als Wes Mantooth (uncredited) |
 | Jerry Stiller als Man in Bar (uncredited) |
| Holly Traister als Secretary (uncredited) |
| Matthew Vlahakis als Zoologist with Panda in Doug or Glen scene (uncredited) |
| Richard Yett als Reporter / Anchor (uncredited) |
| Adam McKay | Director |
| Judd Apatow | Producer |
| Thomas E. Ackerman | Director of Photography |
| Brent White | Editor |
| Alex Wurman | Music |
| Shauna Robertson | Executive Producer |
| David O. Russell | Executive Producer |
| Matt Rebenkoff | First Assistant Director |
| Diane L. Sabatini | Production Supervisor |
| Virginia Randolph-Weaver | Art Direction |
| Mark Molina | Assistant Art Director |
| Jan Pascale | Set Decoration |
| Harry K. Garvin | Steadicam Operator |
| Kimberly Greene | Makeup Department Head |
| Erin Wooldridge | Makeup Artist |
| Toni-Ann Walker | Hair Department Head |
| Joy Zapata | Key Hair Stylist |
| Page Rosenberg-Marvin | Production Coordinator |
| Jeremy Alter | Location Manager |
| Barbara Mesney | Set Designer |
| Sally Thornton | Set Designer |
| Randall D. Wilkins | Set Designer |
| Melissa Bretherton | Additional Editing |
| Ray McIntyre Jr. | Visual Effects Supervisor |
| Reid Paul | Digital Effects Supervisor |
| Richard R. Hoover | Visual Effects Supervisor |
| Diana Stulic Ibanez | Visual Effects Producer |
| David Alexander Smith | CG Supervisor |
| Juel Bestrop | Casting |
| Jeanne McCarthy | Casting |
| Blythe Cappello | Casting |
| David B. Householter | Co-Producer |
| Debra McGuire | Costume Design |
| Clayton Hartley | Production Design |
| Will Ferrell | Writer |
| Adam McKay | Writer |
| Rick Avery | Stunt Coordinator |
| David B. Householter | Unit Production Manager |
| Basil Grillo | Second Assistant Director |
| Rebecca Asher | Script Supervisor |
| Jim Stuebe | Production Sound Mixer |
| Kevin Hyde | Boom Operator |
| Paul Murphey | Video Assist Operator |
| Michael Everett | Chief Lighting Technician |
| Scott Maginnis | Property Master |
| Jeanne Bueche | Art Department Coordinator |
| Adam Tankell | Graphic Designer |
| Louise Del Araujo | Leadman |
| John R. Elliott | Construction Coordinator |
| Michael Menapace | Transportation Coordinator |
| Darrin Mann | Foley Mixer |
| Jeff Gomillion | ADR Mixer |
| Donald Flick | Sound Effects Editor |
| Piero Mura | Sound Effects Editor |
| Richard L. Anderson | Sound Effects Editor |
| Mike Chock | Sound Effects Editor |
| Ellen Segal | Music Editor |
| Erica Weis | Music Editor |
| Philip Rogers | Sound Recordist |
| Gary Burritt | Negative Cutter |
| David Orr | Color Timer |
| Rick Avery | Second Unit Director |
| Ralph Osborn | Dialogue Editor |
| Thomas Jones | Dialogue Editor |
| Solange S. Schwalbe | Dialogue Editor |
| Joan Rowe | Foley Artist |
| Sean Rowe | Foley Artist |
| Tom Calderaro | Orchestrator |
| Harry K. Garvin | "A" Camera Operator |
| Baird Steptoe | First Assistant Camera |
| Darin Necessary | First Assistant Camera |
| John Young | Second Assistant Camera |
| Linda Gacsko | Second Assistant Camera |
| Frank Masi | Still Photographer |
| Darren Michaels | Still Photographer |
| Steven Hiller | "B" Camera Operator |
| Lloyd Moriarity | Key Grip |
| Mark A. Mangini | Supervising Sound Editor |
| Sophia M. Crawford | Stunt Double |
| Joni Avery | Stunts |
| Jack Gill | Stunts |
| Joe Bucaro III | Stunts |
| Lisa Hoyle | Stunts |
