 | Julia Roberts als Barbara Weston |
 | Meryl Streep als Violet Weston |
 | Julianne Nicholson als Ivy Weston |
 | Juliette Lewis als Karen Weston |
 | Ewan McGregor als Bill Fordham |
 | Margo Martindale als Mattie Fae Aiken |
 | Abigail Breslin als Jean Fordham |
 | Chris Cooper als Charlie Aiken |
 | Dermot Mulroney als Steve Huberbrecht |
 | Benedict Cumberbatch als Little Charles Aiken |
 | Misty Upham als Johnna Monevata |
 | Sam Shepard als Beverly Weston |
 | Will Coffey als Sheriff Deon Gilbeau |
 | Newell Alexander als Dr. Burke |
 | Jerry Stahl als Liquor Store Owner |
 | Dale Dye als Radio Announcer |
 | Ivan Allen als Radio Announcer |
 | Arlin Miller als Baseball Announcer |
 | J. Alan Davidson als Young Soldier (uncredited) |
 | Michael Graham als Restaurant Patron (uncredited) |
 | Maria Gus als Funeral Attendee (uncredited) |
| Leland Prater als Funeral Attendee (uncredited) |
| Tracy Letts | Screenplay |
| Steve Traxler | Producer |
| David Gropman | Production Design |
| John Wells | Director |
| Jean Doumanian | Producer |
| Cindy Evans | Costume Design |
| Gustavo Santaolalla | Original Music Composer |
| George Clooney | Producer |
| Grant Heslov | Producer |
| Nancy Haigh | Set Decoration |
| Stephen Mirrione | Editor |
| Daniel J. Leahy | Sound Re-Recording Mixer |
| Jean Ann Black | Makeup Artist |
| Roxane Griffin | Key Hair Stylist |
| Karen Schulz Gropman | Art Direction |
| J. Roy Helland | Makeup Designer |
| Christian P. Minkler | Sound Re-Recording Mixer |
| Mike Prestwood Smith | Sound Re-Recording Mixer |
| Nancy MacLeod | Sound Editor |
| Dave McMoyler | Sound Editor |
| Bill R. Dean | Sound Editor |
| Marc Fishman | Sound Re-Recording Mixer |
| Björn Rehbein | Key Makeup Artist |
| Tony Lamberti | Sound Re-Recording Mixer |
| Matthew W. Mungle | Makeup Artist |
| Lon Bender | Sound Designer |
| Glynna Grimala | Sound Editor |
| Kris Fenske | Sound Editor |
| Toni Marlo | Set Decoration |
| Ian Calip | Second Assistant Director |
| Bob Weinstein | Executive Producer |
| Sean P. Egan | Art Department Coordinator |
| Tracy Letts | Theatre Play |
| Julie Michaels | Stunts |
| Caryn Mower | Stunts |
| Adriano Goldman | Director of Photography |
| Jon Bielich | Stunt Coordinator |
| Ted Barba | Stunt Double |
| Laurie Cummings | Stunts |
| Peewee Piemonte | Stunt Coordinator |
| Tabby Hanson | Stunts |
| Kent Shelton | Stunts |
| Jeff Burleson | Stunt Driver |
| Deb Dyer | Unit Production Manager |
| Harvey Weinstein | Executive Producer |
| Kerry Barden | Casting |
| Paul Schnee | Casting |
| Ron Burkle | Executive Producer |
| Celia D. Costas | Executive Producer |
| Patrick Daly | Producer |
| Ben Famigliett | Executive Producer |
| Jerry Frankel | Executive Producer |
| Arny Granat | Executive Producer |
| Claire Rudnick Polstein | Executive Producer |
| Jeffrey Richards | Executive Producer |
| Matthew W. Mungle | Prosthetic Makeup Artist |
| Lyndell Quiyou | Hairstylist |
| Jordan Roby | Stand In |
