 | Richard Gere als Will Keane |
 | Winona Ryder als Charlotte Fielding |
 | Anthony LaPaglia als John Volpe |
 | Elaine Stritch als Dolores "Dolly" Talbot |
 | Vera Farmiga als Lisa Tyler |
 | Sherry Stringfield als Sarah |
 | Jill Hennessy als Lynn |
 | J.K. Simmons als Dr. Tom Grandy |
 | Sam Trammell als Simon |
 | Mary Beth Hurt als Dr. Sibley |
 | Kali Rocha als Shannon |
 | Bill Raymond als Michael (Doorman) |
 | Tawny Cypress als Melissa |
 | Steven Randazzo als Alberto |
 | George Spielvogel III als Netto |
 | Ranjit Chowdhry als Fakir |
 | Toby Poser als Autumn Woman #1 |
 | Audrey Quock als Eriko |
 | Gabriel Portuondo als 458 Waiter |
 | Laurent Schwaar als 458 Waiter |
 | Patrick Price als 458 Waiter |
 | Ted Koch als 458 Bartender |
| Alvin H. Einbender als 458 Bartender |
| Daniella van Graas als Model at Bar |
 | Rachel Nichols als Model at Bar |
| Steven Ravid als 458 Customer |
| Ron Emanuel als 458 Customer |
| Dan Camins als 458 Customer |
| John Guidera als 458 Customer |
| Russell Hunston als 458 Customer |
 | Nik Pjeternikaj als 458 Customer |
| Paige Handler als Charlotte's Birthday Friend |
 | Liza Lapira als Charlotte's Birthday Friend |
| Sarah Teresa Burns als Little Girl at Playground |
| Earl Carroll als Will's Driver |
| David Filippi als Taxi Driver |
| Becca Lee als Michelle |
| Estelle Robinson als Old Frail Lady |
| Brittney Bunkis als Little Girl at Museum |
| Delores Mitchell als Librarian |
| Hatsumi Yoshida als Clown at Halloween Party |
| Kristi Lee Guinness als 50's Girl at Halloween Party |
| Luca Waldman als Vampire at Halloween Party |
| Daniella Canterman als Twin |
| Deanna Canterman als Twin |
| Harry Burney als Choirmaster |
| Cheyne M. Hansen als Boy at Rockerfeller |
| Iris Flick als Nurse at New Haven Hospital |
| Pamela Twyble als Nurse at Cleveland Heart Institute |
 | Kathleen Goldpaugh als St. Vincent's Nurse |
| Robert Plunket als Grubby Man |
| Shawna Bermender als Ballroom Dancer (uncredited) |
| Lindsay Canton als Young Teacher at Museum (uncredited) |
 | Jamie Harrold als (uncredited) |
 | Kathryn Hayzer als Ballroom Dancer (uncredited) |
| Timothy Huang als 458 Waiter (uncredited) |
 | Christopher Lucas als Dance Partner (uncredited) |
| Nami Paix als Charlotte's Birthday Friend (uncredited) |
 | Rohan Quine als The Moroccan (uncredited) |
| Adriana Souza als Ballroom Dancer (uncredited) |
 | Randy Troy als Package Boy (uncredited) |
| Jade Viggiano als Good Fairy Witch (uncredited) |
| Ruby Yang | Editor |
| Gu Changwei | Director of Photography |
| Allison Burnett | Screenplay |
| Tom Rosenberg | Producer |
| Gabriel Yared | Original Music Composer |
| Joan Chen | Director |
| Gary Lucchesi | Producer |
| Mark Friedberg | Production Design |
| Sheila Jaffe | Casting |
| Georgianne Walken | Casting |
| Andre Lamal | Co-Producer |
| Peter Afterman | Music Supervisor |
| Carol Oditz | Costume Design |
| Ted Tannebaum | Executive Producer |
| Ronald M. Bozman | Executive Producer |
| Amy Robinson | Producer |
| Harvey Waldman | Unit Production Manager |
| Joseph R. Burns | First Assistant Director |
| Michelle L. Keiser | Second Assistant Director |
| Jodi Michelle Pynn | Stunt Coordinator |
| Blaise Corrigan | Stunt Driver |
| Al Cerullo | Pilot |
| James McQuaide | Post Production Supervisor |
| Pat Jackson | Supervising Sound Editor |
| David Parker | Sound Re-Recording Mixer |
| Todd Boekelheide | Sound Re-Recording Mixer |
| Dan Olmsted | Sound Re-Recording Mixer |
| Jess Gonchor | Art Direction |
| Catherine Davis | Set Decoration |
| Mario Ventenilla | Assistant Art Director |
| Nancy Winters | Assistant Art Director |
| Jacqueline Jacobson Scarfo | Assistant Set Decoration |
| Phil Oetiker | Camera Operator |
| Andrew Priestley | First Assistant Camera |
| Rod Calarco | Second Assistant Camera |
| Stephen Consentino | "B" Camera Operator |
| Stephen Consentino | Steadicam Operator |
| Chris Silano | First Assistant "B" Camera |
| Andrew D. Schwartz | Still Photographer |
| Lisa Katcher | Script Supervisor |
| Robert Sciretta | Chief Lighting Technician |
| Thomas Ford | Assistant Chief Lighting Technician |
| Richard Guinness Jr. | Key Grip |
| Glen Engels | Best Boy Grip |
| Rick Marroquin | Dolly Grip |
| Billy Kerwick | Key Rigging Grip |
| Chris Newman | Sound Mixer |
| Marc-Jon Sullivan | Boom Operator |
| Gregg Harris | Cableman |
| Diana Burton | Property Master |
| Rena DeAngelo | Assistant Property Master |
| Sarah Frank | Graphic Designer |
| Timothy Metzger | Leadman |
| Winnie Cheng | Post Production Coordinator |
| Mike Bruining | First Assistant Editor |
| Barbara Harris | ADR Voice Casting |
| Julie Kuehndorf | Unit Publicist |
| Katharina Eggmann | Casting Assistant |
| Grant Wilfley | Extras Casting |
| Steven R. Hammond | Transportation Captain |
| Gene O'Neill | Transportation Co-Captain |
| Brian Carmichael | Video Assist Operator |
| Daniel Sperry | Dolby Consultant |
| Stephen R. Sheridan | Color Timer |
| Theresa Repola Mohammed | Negative Cutter |
| Dianna Stirpe | Dialogue Editor |
| Karen G. Wilson | Dialogue Editor |
| Kyrsten Mate | Sound Effects Editor |
| Robert Shoup | Sound Effects Editor |
| Malcolm Fife | Sound Effects Editor |
| Eric Thompson | ADR Mixer |
| Marnie Moore | Foley Artist |
| Margie O'Malley | Foley Artist |
| Frank Canonica | Sound Recordist |
| Andrew Dorfman | Music Editor |
| Sean Garrett Fogel | Production Coordinator |
