 | Rodney Dangerfield als Thornton Melon |
 | Sally Kellerman als Diane |
 | Burt Young als Lou |
 | Keith Gordon als Jason Melon |
 | Robert Downey Jr. als Derek |
 | William Zabka als Chas |
 | Paxton Whitehead als Phillip Barbay |
 | Adrienne Barbeau als Vanessa |
 | M. Emmet Walsh als Coach Turnbull |
 | Terry Farrell als Valerie |
 | Ned Beatty als Dean Martin |
 | Severn Darden als Dr. Barazini |
 | Sam Kinison als Professor Terguson |
 | Robert Picardo als Giorgio |
 | Kurt Vonnegut Jr. als Self |
 | Edie McClurg als Marge |
 | Sarah Abrell als Sorority Girl |
| Dana Allison als Young Woman |
| Boris Aplon als Tony Meloni |
| Nora Boland als Agnes |
 | Kimberlin Brown als Girl in Dorm Hallway |
| Lisa Denton als Lisa |
| Bob Drew als Contractor |
 | Holly Hayes als Girl in the Crowd |
 | Jason Hervey als Young Thornton |
 | Leslie Scarborough als Coed #1 |
| James Ingersoll als Judge |
 | Michael McGrady als Player #1 |
| Santos Morales als Bartender |
| Beth Peters als Mrs. Stuyvesant |
| Phil Rubenstein als Executive #1 |
 | Timothy Stack als Trendy Man |
 | Steve Sweeney als Security Guard |
| Stacey Toten als Hot Tub Girl |
 | John William Young als Executive #2 |
| Brad Zutaut als Petey |
| Josh Saylor als Student in Diane's Class |
| William Grauer als Drunken Student |
| Kristen Aldrich als Girl in Diane's Class |
 | Becky LeBeau als Hot Tub Girl |
| Tricia Hill als Lisa's Friend |
| Jill D. Merin als Girl at Dorm Party |
| John William James als Man in Stands |
| Eric Alver als Student at Fraternity Party |
| Theresa Lyons als Cashier |
| Dallas Winkler als Rodette |
| Lisa Montgomery als Rodette |
| Kimberlee Carlson als Rodette |
| Curtis Stone als "Twist & Shout" Band Member |
| Michael Reid als "Twist & Shout" Band Member |
| Cactus Moser als "Twist & Shout" Band Member |
| Brian O'Doughtery als "Twist & Shout" Band Member |
| Davey Faragher als "Twist & Shout" Band Member |
| Cliffie Stone als "Twist & Shout" Band Member |
 | Danny Elfman als Oingo Boingo Band Member |
| Leon Schneiderman als Oingo Boingo Band Member |
| Steve Bartek als Oingo Boingo Band Member |
| Dale Turner als Oingo Boingo Band Member |
 | Johnny Vatos Hernandez als Oingo Boingo Band Member |
| John Avila als Oingo Boingo Band Member |
| Sam 'Sluggo' Phipps als Oingo Boingo Band Member |
| Mike Bacich als Oingo Boingo Band Member |
| Rodney Dangerfield | Story |
| Greg Fields | Story |
| Alan Metter | Director |
| William Porter | Screenplay |
| Dennis Snee | Story |
| Harold Ramis | Screenplay |
| Steven Kampmann | Screenplay |
| Chuck Russell | Producer |
| Estelle Endler | Executive Producer |
| Michael Endler | Executive Producer |
| Harold Ramis | Executive Producer |
| Linda DeScenna | Set Decoration |
| Melissa Skoff | Casting |
| Danny Elfman | Original Music Composer |
| Durinda Wood | Costume Design |
| David L. Snyder | Production Design |
| Thomas E. Ackerman | Director of Photography |
| Caro Jones | Casting |
| David Rawlins | Editor |
| Dick Ziker | Stunt Coordinator |
| Gregory J. Barnett | Stunts |
| John C. Meier | Stunts |
| Noon Orsatti | Stunts |
| PJ Torokvei | Screenplay |
| Pete Antico | Stunts |
| Todd Bryant | Stunts |
| Hal Burton | Stunts |
| Justin De Rosa | Stunts |
| Tom Elliott | Stunts |
| Richard Epper | Stunts |
| Gary Epper | Stunts |
| Allan Graf | Stunts |
| Carlos A. Herzer | Stunts |
| Billy Hank Hooker | Stunts |
| Hugh Hooker | Stunts |
| Gary Hymes | Stunts |
| Anderson Martin | Stunts |
| Don Charles McGovern | Stunts |
| William Oliver | Stunts |
| Manny Perry | Stunts |
| Chuck Picerni Jr. | Stunts |
| Steve Picerni | Stunts |
| Carol Rees | Stunts |
| Cyndi Lee Rice | Stunts |
| Michael Runyard | Stunts |
| Spike Silver | Stunts |
| Dean Wein | Stunts |
| Scott Wilder | Stunts |
| Mike Ostavich | Stunt Driver |
| Mark Lindout | Stunt Driver |
| David Draves | Stunt Driver |
| Chuck Russell | Production Manager |
| Robert P. Cohen | First Assistant Director |
| Steve Cohen | Second Assistant Director |
| Mary McLaglen | Production Coordinator |
| Linda Goldner Perry | Music Supervisor |
| Douglas Knapp | Camera Operator |
| David L. Parrish | First Assistant Camera |
| To Lee | Second Assistant Camera |
| Jeff Goldenberg | Second Assistant Camera |
| Bill Nelson | Sound Mixer |
| Jules Strasser | Boom Operator |
| Margie Stone McShirley | Assistant Art Director |
| Edmund Silkaitis | Set Designer |
| Ric McElvin | Leadman |
| Steven Curtis Husch | Set Dresser |
| Tom McCown | Set Dresser |
| David Q. Quick | Property Master |
| Judy Rosenthal | Script Supervisor |
| Esther Vivante | Script Supervisor |
| Ellis Cohen | Costume Supervisor |
| Sandy Ampon | Costumer |
| Janet Stout | Costumer |
| Hallie D'Amore | Makeup Department Head |
| Janna Phillips | Assistant Makeup Artist |
| Donna Barrett Gilbert | Key Hair Stylist |
| Michael Lantieri | Special Effects Supervisor |
| Tim Moran | Special Effects Assistant |
| Dustin Bernard | Second Second Assistant Director |
| Darren T. Holmes | Assistant Editor |
| Joyce Rudolph | Still Photographer |
| Karen Standard | Casting Assistant |
| Fred Judkins | Supervising Sound Editor |
| Tom C. McCarthy | Supervising Sound Editor |
| Neil Burrow | Sound Editor |
| Gordon Davidson | Sound Editor |
| Mark Gordon | Sound Editor |
| James J. Klinger | Sound Editor |
| James Matheny | Sound Editor |
| Don S. Walden | Sound Editor |
| Burton Weinstein | ADR Editor |
| Mike Wilson | Assistant Sound Editor |
| Melinda Cooke | Apprentice Sound Editor |
| Vanessa Theme Ament | Foley Artist |
| Hilda Hodges | Foley Artist |
| Dick Bernstein | Music Editor |
| Bob Badami | Music Editor |
| Chris Carpenter | Sound Effects |
| David Rawlins | Second Unit Director |
| Frederick Moore | Second Unit Director of Photography |
| Jamie Anderson | Camera Operator |
| Jerry Sobul | Second Unit First Assistant Director |
| Michael Looney | Second Assistant Director |
| Alan Gornick | Underwater Camera |
| Jeffrey S. Leader | First Assistant Camera |
| Mary Ann Newfield | Script Supervisor |
| Kenny Rissien | Lighting Technician |
| John Casino | Stunts |
