 | Matthew Mercer als Leon S. Kennedy (voice) |
 | Courtenay Taylor als Ada Wong (voice) |
 | Robin Sachs als Ataman / Ivan Judanovich (voice) |
 | Dave Wittenberg als Buddy / Alexander 'Sasha' Kozachenko (voice) |
 | Wendee Lee als Svetlana Belikova (voice) |
 | Val Tasso als JD (voice) |
 | Salli Saffioti als Ingrid Hunnigan (voice) |
| David Earnest als Secretary / Buddy (voice) |
 | Patrick Seitz als Scarecrow (voice) |
 | Michael McConnohie als Tyrant (voice) |
 | Jolene Andersen als Ada Wong / Ingrid Hunnigan (motion capture) |
| Makoto Kamiya | Director |
| Shoutarou Suga | Writer |
| Shinji Mikami | Creator |
| Kim Hoong Chia | Producer |
| Scott Dolph | Associate Producer |
| Aki Kiuchi | Associate Producer |
| Hiroyuki Kobayashi | Producer |
| Hideki Kuraku | Producer |
| Taro Morishima | Producer |
| Ivan C. Shih | Executive Producer |
| Masao Takiyama | Executive Producer |
| Toshi Tokumaru | Co-Executive Producer |
| Haruhiro Tsujimoto | Executive Producer |
| Hidenori Ueki | Co-Producer |
| Meng Hee Wee | Producer |
| Rei Kondo | Music |
| Shusaku Uchiyama | Music |
| Mami Okada | Casting |
| Shiho Tamura | Production Design |
| Tomo Hyakutake | Special Effects |
| Vasyl Bondarenko | Costumer |
| Dango Takeda | Costume Design |
| Hiroyuki Hamada | Music Director |
| Motohiko Maeda | Sound Engineer |
| Yuriy Zachepylenko | Location Coordinator |
| Takeshi Sawa | Location Manager |
| Aya Masuda | Location Coordinator |
| Shinji Mikami | Original Story |
