 | Nicolas Cage als Frank Pierce |
 | Patricia Arquette als Mary Burke |
 | John Goodman als Larry Verber |
 | Ving Rhames als Marcus |
 | Tom Sizemore als Tom Wolls |
 | Marc Anthony als Noel |
 | Mary Beth Hurt als Nurse Constance |
 | Cliff Curtis als Cy Coates |
 | Aida Turturro als Nurse Crupp |
 | Nestor Serrano als Dr. Hazmat |
| Cynthia Roman als Rose |
 | Sonja Sohn als Kanita |
 | Larry Fessenden als Cokehead |
 | Arthur J. Nascarella als Captain Barney |
 | Martin Scorsese als Dispatcher (voice) |
 | Queen Latifah als Dispatcher Love (voice) |
 | Michael Kenneth Williams als Drug Dealer |
 | Craig muMs Grant als Voice in Crowd |
 | John Heffernan als Mr. Oh |
 | Judy Reyes als ICU Nurse |
 | Afemo Omilami als Griss |
| Cullen O. Johnson als Mr. Burke |
 | Julyana Soelistyo als Sister Fetus |
 | Graciela Lecube als Neighbor Woman |
 | Marylouise Burke als Neighbor Woman |
 | Phyllis Somerville als Mrs. Burke |
| Mary Diveny als Neighbor Woman |
 | Tom Riis Farrell als John Burke |
 | Aleks Shaklin als Arguing Russian |
 | Leonid Citer als Arguing Russian |
| Jesus A. Del Rosario Jr. als Man with Bloody Foot |
| Bernie Friedman als Big Feet |
| Theo Kogan als Prostitute |
 | Fuschia! als Prostitute |
 | Matthew Maher als Mr. Oh's Friend |
| Bronson Dudley als Mr. Oh's Friend |
| Marilyn McDonald als Mr. Oh's Friend |
| Ed Jupp Jr. als Homeless Man in Waiting Room |
| J. Stanford Hoffman als Homeless Man in Waiting Room |
| Rita Norona Schrager als Concerned Hispanic Aunt |
 | Don Berry als Naked Man |
| Mtume Gant als Street Punk |
| Michael A. Noto als Grunt |
 | Omar Scroggins als Bystander |
 | Andy Davoli als Stanley |
| Charlene Hunter als Miss Williams |
 | Jesse Malin als Club Doorman |
| Harper Simon als I.B. Bangin' |
| Joseph Monroe Webb als Drummer |
 | Jon Abrahams als Club Bystander |
| Charis Michelsen als I.B.'s Girlfriend |
 | Lia Yang als Dr. Milagros |
 | Antone Pagán als Arrested Man |
| Melissa Marsala als Bridge & Tunnel Girl |
 | Betty Miller als Weeping Woman |
| Rosemary Gomez als Pregnant Maria |
| Luis Rodriguez als Carlos |
 | Sylva Kelegian als Crackhead |
| Frank Ciornei als Dr. Mishra |
 | Catrina Ganey als Nurse Odette |
| Jennifer Lane Newman als Nurse Advisor |
| John Bal als Police in Hospital |
| Raymond Cassar als Police in Hospital |
 | Tom Cappadona als Drunk |
 | Jack O'Connell als Drunk |
| Randy Foster als Drunk |
 | Richard Spore als Homeless Suicidal |
 | James Hanlon als Fireman |
| Chris Edwards als Fireman |
| Mark Giordano als Police Sergeant |
 | Michael Mulheren als Cop in Elevator |
 | David Zayas als Cop in Elevator |
 | Terry Serpico als Cop #1 |
| Floyd Resnick als Cop #3 |
| Megan Leigh als Surgeon |
| David Vasquez als Screaming Man |
 | Joseph P. Reidy als ICU Doctor |
| Erica Bamforth als Urchin Prostitute (uncredited) |
| Peju Bamgboshe als Child Zombie (uncredited) |
 | Carolyn Campbell als Policewoman (uncredited) |
 | Michael Carbonaro als Club Kid (uncredited) |
| Joe Connelly als Catatonic Patient in Suede Coat (uncredited) |
 | Brian Smyj als Cop #2 (uncredited) |
| Martin Scorsese | Director |
| Paul Schrader | Screenplay |
| Thelma Schoonmaker | Editor |
| Robert Richardson | Director of Photography |
| Scott Rudin | Producer |
| Barbara De Fina | Producer |
| Elmer Bernstein | Original Music Composer |
| Eric Steel | Co-Producer |
| Louis Sabat | Boom Operator |
| Ellen Lewis | Casting |
| Jeff Levine | Associate Producer |
| Bruce S. Pustin | Executive Producer |
| Joseph P. Reidy | Co-Producer |
| Mark Roybal | Associate Producer |
| Adam Schroeder | Executive Producer |
| Phillip V. Caruso | Still Photographer |
| Bobby Mackston | Music Editor |
| Dante Ferretti | Production Design |
| Rita Ryack | Costume Design |
| William F. Reynolds | Set Decoration |
| Robert Guerra | Art Direction |
| Joseph Coscia | Hairstylist |
| William A. Farley | Key Hair Stylist |
| Jane DiPersio | Makeup Artist |
| Scott W. Farley | Hairstylist |
| Leon Weisinger | Makeup Artist |
| Shell Hecht | Production Supervisor |
| Martha Pinson | Script Supervisor |
| Vincent Galindez | Camera Operator |
| G. A. Aguilar | Stunt Coordinator |
| Michael Owens | Visual Effects Supervisor |
| Jill Brooks | Visual Effects Producer |
| Glen Pangione | Construction Coordinator |
| Gregor Tavenner | First Assistant Camera |
| Larry McConkey | Steadicam Operator |
| Carol F. Doran | Wigmaker |
| James Cappello | Carpenter |
| P.J. Haines | Chef |
| Carlos Bernal | Driver |
| Rich Fellegara | Set Medic |
| John Ottesen | Special Effects Coordinator |
| Chris Cenatiempo | Stunts |
| Timothy Shannon | Transportation Captain |
| Eric Myers | Unit Publicist |
| John Bartle | Visual Effects Editor |
| Bob Kaiser | Color Timer |
| Scott Brock | First Assistant Editor |
| Doug Dalisera | Best Boy Electric |
| John Billeci | Electrician |
| Russell Engels | Gaffer |
| Ken Connors | Rigging Gaffer |
| Gayle Keller | Casting Associate |
| Len Murach | Location Manager |
| Emilie A. Bernstein | Orchestrator |
| Tom Fleischman | Sound Re-Recording Mixer |
| Philip Stockton | Supervising Sound Editor |
| Susan Greenhow | Visual Effects Coordinator |
| Kendall McCarthy | Post Production Supervisor |
| Ashlee Burnette | Production Office Assistant |
| Marco Kyris | Stand In |
| Will Sweeney | Production Intern |
| Joseph Buonocore | Transportation Co-Captain |
| Marion Billings | Publicist |
| Bruce S. Pustin | Unit Production Manager |
| James Sabat | Sound Mixer |
| Joseph P. Reidy | First Assistant Director |
| Elmer Bernstein | Conductor |
| James Bono | Assistant Property Master |
| Dennis Causey | Set Dresser |
| Denise Schwab | Camera Loader |
| Patrick McGrath | Dolly Grip |
| Richard Guinness Jr. | Key Grip |
| Kevin Ritter | Key Costumer |
| Linda Grimes | Key Makeup Artist |
| Joanna Brett | Wardrobe Supervisor |
| Christopher Surgent | Second Assistant Director |
| Bruce Winant | ADR Voice Casting |
| Karen Koula Sossiadis | Assistant Production Coordinator |
| Marissa Littlefield | ADR Editor |
| Debora Lilavois | Apprentice Sound Editor |
| Kate Eales | Assistant Sound Editor |
| Benjamin Cheah | Foley Editor |
| Eugene Gearty | Sound Effects Designer |
| Becky Sullivan | Supervising ADR Editor |
| Fred Rosenberg | Dialogue Editor |
| Laura Civiello | Dialogue Editor |
| James Mazzola | Property Master |
| Greg Hale | Second Second Assistant Director |
| Jay Halligan | Construction Grip |
| Thomas Yacuk | Key Construction Grip |
| Howard Davidson | Grip |
| David Boulton | ADR Recording Engineer |
| Alex Raspa | ADR Recordist |
| Marko Costanzo | Foley Artist |
| George A. Lara | Foley Recordist |
| Will Ralston | Foley Supervisor |
| Nick Seuser | Additional Visual Effects |
| Erin Collins Butler | Visual Effects Production Assistant |
| Jalil Jay Lynch | Stunt Driver |
| Will Arnot | Additional Grip |
| Tracey Gudwin | Assistant Camera |
| Glen Engels | Best Boy Grip |
| Jeanne Vienne | Second Assistant Camera |
| James Y. Kwei | Consulting Editor |
| James D. Lee | Assistant Location Manager |
| Damon Michael Gordon | Location Assistant |
| Jon Alexander | Compositing Supervisor |
| Eric Person | Digital Compositor |
| Janos Pilenyi | Effects Supervisor |
| Lee Genick | Extras Casting Assistant |
| Theresa Marsh | First Assistant Accountant |
| Ronald Paul | Generator Operator |
| Rueven Halevi | Intern |
| Billy Kerwick | Key Rigging Grip |
| Penni Smith | Payroll Accountant |
| Erica Bamforth | Production Assistant |
| Reid Warman | Production Secretary |
| Kellyann Wargo | Second Assistant Accountant |
| Narges Takesh | Story Editor |
| Susan Callahan | Technical Advisor |
| Joe Connelly | Novel |
| Joe Connelly | Technical Advisor |
| John Davis | Storyboard Artist |
| Conrad E. Palmisano | Stunt Driver |
| Peter Epstein | Stunts |
