 | Ashley Judd als Agnes White |
 | Michael Shannon als Peter Evans |
 | Harry Connick Jr. als Jerry Goss |
 | Lynn Collins als R. C. |
 | Brían F. O'Byrne als Dr. Sweet |
 | Neil Bergeron als Man in Grocery Store |
 | Bob Neill als Pizza Harris (voice) |
| William Friedkin | Director |
| Tracy Letts | Screenplay |
| Kimberly C. Anderson | Producer |
| Michael Burns | Producer |
| Gary Huckabay | Producer |
| Michael Ohoven | Executive Producer |
| Malcolm Petal | Producer |
| Andreas Schardt | Producer |
| Jim Seibel | Executive Producer |
| Holly Wiersma | Producer |
| Brian Tyler | Original Music Composer |
| Michael Grady | Director of Photography |
| Darrin Navarro | Editor |
| Tracy Letts | Theatre Play |
| Bonnie Timmermann | Casting |
| Franco-Giacomo Carbone | Production Design |
| Frank J. Zito III | Set Decoration |
| Caleb Guillotte | Art Department Coordinator |
| David K. Nami | Special Effects Supervisor |
| Robert Vazquez | Special Effects Supervisor |
| Stephen Vincent | Casting Associate |
| Dianne Kennedy | Costume Supervisor |
| Pamela Waggoner | Set Costumer |
| Jillian Amburgey | Script Supervisor |
| Beth Miller | Hair Department Head |
| Patrick Melville | Hairstylist |
| Brad Wilder | Makeup Department Head |
| Steve Boeddeker | Sound Designer |
| Jon Kuyper | Line Producer |
| Bonnie Timmermann | Co-Producer |
| Peggy A. Schnitzer | Costume Designer |
| Jeffrey Haupt | Sound Mixer |
| Jay Faires | Music Supervisor |
| Jon Kuyper | Unit Production Manager |
| Michael Salven | First Assistant Director |
| Steve Lonano | Second Assistant Director |
| Barry Bedig | Property Master |
| Franco-Giacomo Carbone | Art Direction |
| Anthony Friedkin | Still Photographer |
| Ruby C. Haupt | Boom Operator |
| Mike Karasick | Gaffer |
| Gilly Charbonnet | Key Grip |
| Timothy A. Wonsik | Costume Supervisor |
| Beth Miller | Hairstylist |
| Brad Wilder | Makeup Artist |
| Christien Tinsley | Special Effects Makeup Artist |
| Michelle Rolland | Property Master |
| Serj Tankian | Additional Music |
| Ronald Eng | Supervising Sound Editor |
| Catherine Rowe | Foley Artist |
| Sean Rowe | Foley Artist |
| Aaron Levy | Sound Re-Recording Mixer |
| Terry Hager | Color Timer |
