 | Kim Basinger als Holli Would |
 | Gabriel Byrne als Jack Deebs |
 | Brad Pitt als Detective Frank Harris |
 | Michele Abrams als Jennifer Malley |
 | Deirdre O'Connell als Isabelle Malley |
 | Janni Brenn als Agatha Rose Harris |
 | William Frankfather als Cop |
 | Greg Collins als Cop |
 | Maurice LaMarche als Interrogator #2 / Mash / drunken bar patron / Dr. Vincent "Vegas Vinnie" Whiskers / Jack Deebs (super hero version) (voice) |
 | Michael David Lally als Sparks (voice) |
 | Carrie Hamilton als Comic Bookstore Cashier |
 | Stephen Worth als Bash (performance model) / Comic Store Patron |
| Murray Podwal als Store Patron |
| Jenine Jennings als Holli Would / Lonette (performance model) / Craps Bunny (voice) |
 | Joey Camen als Interrogator #1 / Slash / Holli's door (voice) |
 | Paul Ben-Victor als Valet |
 | Gary Friedkin als Mash |
 | Gregory Snegoff als Bash (voice) |
 | Candi Milo als Bob / Lonette (voice) |
 | Charlie Adler als Nails (voice) |
 | Patrick Pinney als Bouncer (voice) |
 | Frank Sinatra Jr. als Self |
 | Kevin L. Jackson als Lucky's Bouncer (voice) |
| Big Yank als Plaza Bouncer |
| Bobby Bell als Bob |
 | Clare Hoak als Lonette |
| Antonio Hoyos als Doc Whiskers |
| Leroy Thompson als Nails |
| Ralph Bakshi | Director |
| Michael Grais | Screenplay |
| Mark Victor | Screenplay |
| Al Holter | Visual Effects |
| Greg Tiernan | Animation |
| Micki Zurcher | Animation Manager |
| David 'Joey' Mildenberger | Visual Effects |
| Silvia Pompei | Animation Manager |
| Bingo Ferguson | Camera Operator |
| Michael Grais | Writer |
| Mark Victor | Writer |
| Frank Mancuso Jr. | Producer |
| Vikki Williams | Associate Producer |
| Mark Isham | Music |
| John A. Alonzo | Director of Photography |
| Steve Mirkovich | Editor |
| Annamária Szántó Komlóssy | Editor |
| Carrie Frazier | Casting |
| Michael Corenblith | Production Design |
| David J. Bomba | Art Direction |
| Malissa Daniel | Costume Design |
| Kristine Brown | Visual Effects |
| Pat Clark | Visual Effects |
| Kelly G. Crawford | Visual Effects Editor |
| Phil Cummings | Visual Effects |
| Mike Disa | Visual Effects |
| Daniel Eblen | Visual Effects |
| Ellen Greenblatt | Visual Effects |
| Hae Sook Hwang | Visual Effects |
| David M. Kcenich | Visual Effects |
| David Kracov | Visual Effects |
| Nate Pacheco | Visual Effects |
| Tom Pope | Visual Effects |
| Conrad Vernon | Visual Effects |
| Dan Wanket | Visual Effects |
| Ted T. Bemiller | Camera Operator |
| William Bemiller | Camera Operator |
| Bill Bloom | Camera Department Manager |
| Robert Jacobs | Camera Operator |
| Darryl Gordon | Animation |
| Steven E. Gordon | Animation |
| Jack Freeman | Makeup Artist |
| Emily Katz | Key Makeup Artist |
| Rubén Domingo | Sound Editor |
| Eugene Gearty | Sound Designer |
| Rick Hart | Sound Re-Recording Mixer |
| Bill Koepnick | Sound Effects Editor |
| Skip Lievsay | Sound Designer |
| Roger Mende | Sound Effects |
| Donald O. Mitchell | Sound Re-Recording Mixer |
| Frank A. Montaño | Sound Re-Recording Mixer |
| Hamilton Sterling | Supervising Sound Editor |
| John Joseph Thomas | Sound Effects Editor |
| Gregory J. Barnett | Stunts |
| John C. Meier | Stunts |
| Jeffrey J. Dashnaw | Stunts |
| Buddy Joe Hooker | Stunts |
| Juli Murphy | Visual Effects |
| Ken Blazer | Stunts |
| Nick Brett | Stunts |
| Kenny Bates | Stunts |
| Danny Epper | Stunts |
| Gary Davis | Stunts |
| Chris Durand | Stunts |
| Maria R. Kelly | Stunts |
| Steve Kelso | Stunts |
| Matt Johnston | Stunts |
| Cyndi Lee Rice | Stunts |
| Kim Renee | Utility Stunts |
| Lynn Salvatori | Stunts |
| R.A. Rondell | Stunt Coordinator |
| David Welch | Stunts |
| Dick Ziker | Stunts |
| Scott Wilder | Stunts |
