 | Matthew McConaughey als Ron Woodroof |
 | Jennifer Garner als Eve |
 | Jared Leto als Rayon |
 | Denis O'Hare als Dr. Sevard |
 | Steve Zahn als Tucker |
 | Michael O'Neill als Richard Barkley |
 | Dallas Roberts als David Wayne |
 | Griffin Dunne als Dr. Vass |
 | Kevin Rankin als T.J. |
 | Donna DuPlantier als Nurse Frazin |
 | Deneen Tyler als Denise |
 | J.D. Evermore als Clint |
 | Ian Casselberry als Hispanic Orderly |
 | Noelle Wilcox als Kelly |
| Bradford Cox als Sunny |
 | Rick Espaillat als Michael |
 | Lawrence Turner als Foreman |
 | Lucius Falick als Freddie |
 | James DuMont als Rayon's Father |
 | Jane McNeill als Francine Suskind |
| Don Brady als Tucker's Father |
| Matthew Thompson als Effeminate Man |
 | Tony Bentley als Judge |
 | Sean Boyd als Border Agent |
 | Rachel Wulff als News Anchor |
 | Neeona Neal als Stripper |
 | Scott Takeda als Mr. Yamata |
 | Jonathan Tabler als Rick Ferris |
 | Joji Yoshida als Dr. Hiroshi |
 | Carl Palmer als FDA Customs Agent |
 | Martin Covert als Ian |
 | Douglas M. Griffin als Rog |
| David Lichtenstein als Cop |
| Craig Borten als Quicksilver Cowboy |
| Henry Frost als Gay Cowboy |
 | Arthur Smith als Rodeo Announcer |
| Adam Dunn als Neddie Jay (uncredited) |
 | Juliet Reeves London als Rodeo Girl (uncredited) |
 | Jeanine Hill als Rodeo Girl (uncredited) |
| Sarah Eilts als Ron's Hooker (uncredited) |
 | Lily Virginia Filson als Dancer (uncredited) |
 | Steffie Grote als The Girl With The Snake Tattoo (uncredited) |
| Jean-Marc Vallée | Director |
| Javiera Varas | Art Direction |
| Holly Wiersma | Executive Producer |
| Kerry Barden | Casting |
| David L. Bushell | Executive Producer |
| Logan Levy | Executive Producer |
| Joe Newcomb | Executive Producer |
| Nicolas Chartier | Executive Producer |
| Martin Pensa | Editor |
| Robbie Brenner | Producer |
| Jean-Marc Vallée | Editor |
| Cassian Elwes | Executive Producer |
| Zev Foreman | Executive Producer |
| Tony Notargiacomo | Executive Producer |
| Rachel Winter | Producer |
| Rich Delia | Casting |
| John Paino | Production Design |
| Paul Schnee | Casting |
| Melanie Deforrest | Makeup Artist |
| Adruitha Lee | Hair Department Head |
| Robin Mathews | Makeup Department Head |
| Yves Bélanger | Director of Photography |
| Craig Borten | Writer |
| Melisa Wallack | Writer |
| Michael Sledd | Unit Production Manager |
| Urs Hirschbiegel | First Assistant Director |
| Marc Cote | VFX Supervisor |
| Nathan Ross | Executive Producer |
| Michael Sledd | Co-Producer |
| Martin Pinsonnault | Sound Supervisor |
| Parry Creedon | Co-Producer |
| Mark C. Stevens | Second Assistant Director |
| Kurt Swanson | Costume Design |
| Bart Mueller | Costume Design |
| Alex Terzieff | Stunt Coordinator |
| Parry Creedon | Production Supervisor |
| Jessica Lee | Art Department Coordinator |
| Roger Johnson | Graphic Designer |
| Robert Covelman | Set Decoration |
| Gus Coto | Leadman |
| Selina van den Brink | Set Decoration Buyer |
| Luis Lopez DeVictoria | Camera Operator |
| Nicolas Marion | First Assistant Camera |
| Jose Figueroa-Baez | Second Assistant Camera |
| Anne Marie Fox | Still Photographer |
| Dick Hansen | Production Sound Mixer |
| Leonard Suwalski | Boom Operator |
| Mona Medawar | Script Supervisor |
| John R.C. Davis | Production Coordinator |
| Ian D. Navran | Assistant Production Coordinator |
| Brian Evans | Production Accountant |
| Kolie Wegner | First Assistant Accountant |
| Diana Ascher | Post Production Accountant |
| Richard Ball | Key Grip |
| Renaldo Jackson | Gaffer |
| Sidney Brisco | Gaffer |
| Andrew Wert | Property Master |
| Hunter Wert | Assistant Property Master |
| Katie Riggs | Special Effects Coordinator |
| Linda Gardar | Costume Supervisor |
| Jennifer Kamrath | Key Set Costumer |
| Kat Percy | Key Hair Stylist |
| Leonard E. Reynolds III | Location Manager |
| Les Arceneaux | Assistant Location Manager |
| Scot Middleton | Construction Coordinator |
| David Dorretto | Construction Foreman |
| Kevin Lum | Second Second Assistant Director |
| Justin Coulter | Extras Casting |
| A. Welch Lambeth | Transportation Coordinator |
| Rick Davis | Transportation Captain |
| Jeanmarie Murphy-Burke | Unit Publicist |
| Pierre Thériault | Post Production Supervisor |
| Martin Pinsonnault | Sound Designer |
| Martin Pinsonnault | Sound Effects Editor |
| Claire Pochon | Dialogue Editor |
| Mireille Morin | ADR Editor |
| Anton Fischlin | Sound Designer |
| Anton Fischlin | Sound Effects Editor |
| Paul Col | First Assistant Sound Editor |
| Samuel Gagnon-Thibodeau | Assistant Sound Editor |
| Simon Meilleur | Foley Artist |
| Jo Caron | Foley Recording Engineer |
| Paul Col | Foley Editor |
