 | Dwayne Johnson als Krypto the Superdog (voice) |
 | Kevin Hart als Ace the Bat-Hound (voice) |
 | John Krasinski als Clark Kent / Superman (voice) |
 | Keanu Reeves als Bruce Wayne / Batman (voice) |
 | Kate McKinnon als Lulu (voice) |
 | Vanessa Bayer als PB (voice) |
 | Natasha Lyonne als Merton (voice) |
 | Diego Luna als Chip (voice) |
 | Jameela Jamil als Diana Prince / Wonder Woman (voice) |
 | Marc Maron als Lex Luthor (voice) |
 | Dascha Polanco als Jessica Cruz / Green Lantern (voice) |
 | Olivia Wilde als Lois Lane (voice) |
 | Jemaine Clement als Arthur Curry / Aquaman (voice) |
 | Daveed Diggs als Victor Stone / Cyborg (voice) |
 | John Early als Barry Allen / The Flash (voice) |
 | Ben Schwartz als Mark / Fire Guinea Pig (voice) |
 | Thomas Middleditch als Keith / Ice Guinea Pig (voice) |
 | Maya Erskine als Mercy Graves (voice) |
 | Yvette Nicole Brown als Patty (voice) |
 | Alfred Molina als Jor-El (voice) |
 | Lena Headey als Lara (voice) |
 | Keith David als Dog-El (voice) |
 | Busy Philipps als Foofy Dog (voice) |
 | Dan Fogler als Carl / Pilot / Racer (voice) |
 | Winona Bradshaw als Whiskers (voice) |
 | David Pressman als Corgi (voice) |
| Sam Levine als Waffles / Robot Guards (voice) |
 | Jared Stern als Bathtub Guy / JLA Hotline (voice) |
 | Michelle Morgan als Mech Suit (voice) |
| Amanda Ames als Guinea-Pigasus (voice) |
| Gavin McCrillis als Black Kitten (voice) |
| Bob Kane | Characters |
| Ruth Lambert | Casting |
| Steve Jablonsky | Original Music Composer |
| Dwayne Johnson | Producer |
| Jerry Siegel | Characters |
| Joe Shuster | Characters |
| Allison Abbate | Executive Producer |
| Nicholas Stoller | Executive Producer |
| Glenn Ficarra | Executive Producer |
| John Requa | Executive Producer |
| Jared Stern | Director |
| Jared Stern | Producer |
| Jared Stern | Writer |
| Bill Finger | Characters |
| Dany Garcia | Producer |
| William Moulton Marston | Characters |
| Kathleen Shugrue | Art Direction |
| Bill R. Dean | Supervising Sound Editor |
| Sam Levine | Co-Director |
| Hiram Garcia | Producer |
| Kristen Anderson | Art Direction |
| John Whittington | Writer |
| Season Kent | Music Supervisor |
| Courtenay Valenti | Executive Producer |
| Sharon Taylor | Executive Producer |
| David Egan | Editor |
| Daniela Kriston | Researcher |
| Camilo Castro | Character Designer |
| Jhoanne Reyes | Editor |
| Patricia Hicks | Producer |
| Kim Taylor | Production Design |
| Vi-Dieu Nguyen | Head of Story |
| Ryan Carlson | Art Direction |
| Chris Leahy | Executive Producer |
