 | Luke Goss als Carl 'Luke' Lucas / Frankenstein |
 | Lauren Cohan als September Jones |
 | Sean Bean als Markus Kane |
 | Danny Trejo als Goldberg |
 | Ving Rhames als Weyland |
 | Tanit Phoenix als Katrina Banks |
 | Robin Shou als 14K |
 | Joe Vaz als Rocco |
 | Frederick Koehler als Lists |
 | Sean Higgs als Hillbilly Con |
 | Patrick Lyster als Warden Medford Parks |
 | Deobia Oparei als Big Bill |
 | Hennie Bosman als Xander Grady |
 | Warrick Grier als Calin |
 | Danny Keogh als Dr. Klein |
 | Ryan Kruger als Fat Guard |
 | Robyn LeAnn Scott als Big Angry Female Guard |
 | Alex Lorre als Driver |
 | Stephen Jennings als Defense Attorney |
 | Tyrone Keogh als Camerman #2 |
 | Trayan Milenov-Troy als Scars |
 | Jenna Saras als Stunning Woman |
 | Tanya van Graan als Holly |
| Paul W. S. Anderson | Producer |
| Jan Glaser | Casting |
| Moira Anne Meyer | Costume Design |
| Jeremy Bolt | Producer |
| Roel Reiné | Director |
| Paul Haslinger | Music |
| Tony Giglio | Writer |
| Tony Giglio | Screenplay |
| David Bloomer | Still Photographer |
| Andrew Orlando | Art Direction |
| Roel Reiné | Camera Operator |
| Megan Tanner | Makeup Department Head |
| Patrick O'Connor | Assistant Art Director |
| Javier Bennassar | Supervising Sound Editor |
| Leo Vezzali | Visual Effects Producer |
| Sarel Pretorius | Steadicam Operator |
| Radu Ion | Editor |
| Morten Nielsen | Location Manager |
| Tyler Kehl | Visual Effects Producer |
| David Van Woert | Visual Effects Producer |
| Joy Sapieka | Unit Publicist |
| Susan Barras | Costume Supervisor |
| Melinda Launspach | Set Decoration |
| Sze-Wun Li | Sound Effects Editor |
| Steven Hodgson | Visual Effects Supervisor |
| Laszlo Mates | Visual Effects Supervisor |
| Johnny Breedt | Production Design |
| Leslie Shatz | Sound Re-Recording Mixer |
| Herman P. Koerts | Editor |
| Stephen Webster | Sound Re-Recording Mixer |
| Cordell McQueen | Special Effects Coordinator |
| Adam Horton | Stunt Coordinator |
| Oleksandr Kucherov | Visual Effects Supervisor |
| Anton Mitrakhov | Visual Effects Supervisor |
| Damien Walsh | Camera Operator |
| Roger Corman | Executive Producer |
| Mike Elliott | Producer |
| Paula Wagner | Executive Producer |
| Alan Shearer | Line Producer |
| Simone Stubbs | Makeup Artist |
| Marvin Saven | Associate Producer |
| Talia Barak | Makeup Artist |
| Greg Holstein | Associate Producer |
| Jilly Greenham | Hairstylist |
| Paul W. S. Anderson | Characters |
| Paul W. S. Anderson | Story |
| John McKay | Director of Photography |
| Clinton Smith | Contact Lens Technician |
| Clinton Smith | Prosthetic Designer |
| Kerry Skelton | Key Makeup Artist |
| Gerald Sutherland | Special Effects Makeup Artist |
| Cailin Nicolson | Special Effects Makeup Artist |
| Gabriel Williams | First Assistant Director |
| Gene Gualdi | Second Assistant Director |
| Shamiel Soni | Second Assistant Director |
| Christo van Schalkwyk | Second Assistant Director |
| Frederich Fiela Jonck | Third Assistant Director |
| Dénes Molnár | Concept Artist |
| Andor Záhonyi | Concept Artist |
| Cecelia van Straaten | Draughtsman |
| Lucille Doman | Graphic Designer |
| Kate Hilson | Graphic Designer |
| Szentgyörgyi Ottó | Graphic Designer |
| Damian Fermor | Property Master |
| Vicky Sawkins | Set Dresser |
| Jacobus Smit | Set Dresser |
| Mark Risk | Storyboard Artist |
| Ashley Dennis | Casting Assistant |
| Jaci Cheiman | Casting Coordinator |
| Jacomina Jankowitz | Assistant Costume Designer |
| Rick de Souza | Key Costumer |
| Marius Pretorius | Painter |
| Lisa Van Der Merwe | Painter |
| Bernard Esterhuysen | Digital Imaging Technician |
| Keith Smith | Dolly Grip |
| Brandon Daniels | Electrician |
| Zolani Gojo | Electrician |
| Myron Mance | Electrician |
| Phillip Mhlabane | Electrician |
| Quintin Pretorius | Electrician |
| Brent Sauls | Electrician |
| Zane Harrison | First Assistant Camera |
| Emmanuel Chonco Sithole | Gaffer |
| Karl Fredrick | Grip |
| Regan Mitchell | Grip |
| Lazarus Seoposenwe | Grip |
| Jason Venter | Grip |
| Jens Bacher | Key Grip |
| Keith Saayman | Libra Head Technician |
| Johan Horjus | Phantom Operator |
| Margaret Muggleston | Second Assistant Camera |
| Nigel Tompkins | Second Assistant Camera |
| Gerhard Geldenhuys | Second Assistant Camera |
| Attila Csepy | 3D Artist |
| Norbert Fuchs | 3D Artist |
| Miklós Polgár | 3D Artist |
| Andor Záhonyi | Compositing Lead |
| Nick Hsieh | Compositing Supervisor |
| Xiaoming Wang | Compositor |
| Hansu Zhan | Compositor |
| Heinrich Maas | Digital Compositor |
| Dénes Molnár | Digital Compositor |
| Carl Schröter | Digital Compositor |
| Yevgen Skorobogatko | Digital Compositor |
| Gyuri Szlamka | Digital Compositor |
| Johannes Bogenhauser | Digital Compositor |
| Oliver Heinrich | Digital Compositor |
| Avital Shalev | Digital Intermediate Producer |
| Roman Bazyuchenko | VFX Artist |
| Patricia Feldmann | VFX Artist |
| Thomas Lehmann | VFX Artist |
| Lise-Marie Bothma | Prosthetics |
| Cordell McQueen | Pyrotechnician |
| Doug Hardy | Special Effects Technician |
| Tyrell Kemlo | Special Effects Technician |
| Calen Van Schalkwyk | Special Effects Technician |
| Travis MacKay | ADR Mixer |
| Simon McCormick | ADR Recordist |
| Ryan Collins | Assistant Sound Editor |
| Callie Thurman | Assistant Sound Editor |
| Jacques Pienaar | Boom Operator |
| Sarah Payan | Dialogue Editor |
| Lara Dale | Foley Artist |
| Ellen Heuer | Foley Artist |
| Brian Dunlop | Foley Editor |
| A. Josh Reinhardt | Foley Mixer |
| Conrad Kuhne | Production Sound Mixer |
| Javier Bennassar | Sound Designer |
| Sue Gates | Colorist |
| Rita DaSilva | First Assistant Editor |
| Valerie Rose | Assistant Production Coordinator |
| Gert Uys | Pilot |
| Olly Steele | Weapons Master |
| Billi Bruins | Production Accountant |
| Demian Hauptle | Production Assistant |
| Jayson Snyman | Production Assistant |
| Megan Truter | Production Assistant |
| Tina Caldeira | Production Coordinator |
| Helene Turvey | Unit Publicist |
| Clinton du Preez | Transportation Captain |
| Paul Di Franco | Music Supervisor |
| Jeremy Ball | Visual Effects Supervisor |
