 | Walter Matthau als George Wilson |
 | Mason Gamble als Dennis Mitchell |
 | Joan Plowright als Martha Wilson |
 | Christopher Lloyd als Switchblade Sam |
 | Lea Thompson als Alice Mitchell |
 | Robert Stanton als Henry Mitchell |
 | Amy Sakasitz als Margaret Wade |
 | Kellen Hathaway als Joey |
 | Paul Winfield als Chief of Police |
 | Natasha Lyonne als Polly |
 | Devin Ratray als Mickey |
 | Hank Johnston als Gunther |
 | Melinda Mullins als Andrea |
 | Billie Bird als Edith Butterwell |
 | Bill Erwin als Edward Little |
 | Arnold Stang als Photographer |
 | Ben Stein als Boss |
| Ethel Gerstein als Gaggle Lady #1 |
| Rebecca Hogan als Gaggle Lady #2 |
| Leona Toppel als Gaggle Lady #3 |
| Peggy Goldberg als Gaggle Lady #4 |
| Jack McGuigan als Gaggle Man |
| Corey Vane als Mike |
| Casey Gamble als Hide and Seeker |
 | Diana Rein als Babysitter |
| Robert A. Saunders als Broken Arm Babysitter |
| Beverly J. O'Donnell als Elderly Babysitter |
 | Suzy Brack als Next-Door Neighbor (uncredited) |
 | Thomas F. Evans als Dennis Mitchell's Neighbor (uncredited) |
| Kirk Kelly als Kid in Window (uncredited) |
 | Jeannie Russell als Neighbor (uncredited) |
| John Hughes | Screenplay |
| Nick Castle | Director |
| Ernest Chambers | Executive Producer |
| John Hughes | Producer |
| Thomas E. Ackerman | Director of Photography |
| Alan Heim | Editor |
| Hank Ketcham | Novel |
| Richard Vane | Producer |
| Kenneth Hall | Music Editor |
| Dave McMoyler | Sound Editor |
| Wylie Stateman | Supervising Sound Editor |
| Michael D. Wilhoit | Supervising Sound Editor |
| Richard Dwan Jr. | Sound Editor |
| Kevin E. Carpenter | Sound Re-Recording Mixer |
| Rick Hart | Sound Re-Recording Mixer |
| Jeffrey J. Haboush | Sound Re-Recording Mixer |
| Dino DiMuro | Sound Effects Editor |
| Randy Kelley | Sound Effects Editor |
| Kelly Oxford | Sound Effects Editor |
| Scott Martin Gershin | Sound Designer |
| Marsha Blackburn | Still Photographer |
| Mary Tallman | Script Supervisor |
| Jan Evans | Script Supervisor |
| James D. Bissell | Production Design |
| Bridget Kelly | Costume Design |
| Ann Roth | Costume Design |
| Eve Cauley | Set Decoration |
| Michael Baugh | Art Direction |
| Steven Wolff | Art Direction |
| R. Anthony Brown | Unit Production Manager |
| Cheryl Beasley Blackwell | Costume Supervisor |
| Scott Stambler | Music Editor |
| Jerry Goldsmith | Original Music Composer |
| Darrell Hall | Music Editor |
| Jeffrey A. Williams | Boom Operator |
| John S. Robertson | Key Grip |
| Chris Hogan | Dialogue Editor |
| Christopher Assells | Dialogue Editor |
| Dan M. Rich | Dialogue Editor |
| James R. Alexander | Sound Mixer |
| William D'Ambra | Property Master |
| Daniel Chuba | Visual Effects Producer |
| Jane Jenkins | Casting Director |
| Debbie Lee Carrington | Stunt Double |
