 | Benedict Cumberbatch als Dr. Stephen Strange / Sinister Strange / Defender Strange |
 | Elizabeth Olsen als Wanda Maximoff / The Scarlet Witch |
 | Chiwetel Ejiofor als Baron Karl Mordo / Cameron Taragel |
 | Benedict Wong als Wong |
 | Xochitl Gomez als America Chavez |
 | Jett Klyne als Tommy Maximoff |
 | Julian Hilliard als Billy Maximoff |
 | Sheila Atim als Sara |
 | Adam Hugill als Rintrah (voice) |
 | Michael Stuhlbarg als Dr. Nicodemus 'Nic' West |
 | Rachel McAdams als Dr. Christine Palmer |
 | Hayley Atwell als Peggy Carter / Captain Carter |
 | Anson Mount als Blackagar Boltagon / Black Bolt |
 | Lashana Lynch als Maria Rambeau / Captain Marvel |
 | John Krasinski als Reed Richards / Mr. Fantastic |
 | Patrick Stewart als Professor Charles Xavier / Professor X |
 | Charlize Theron als Clea |
 | Bruce Campbell als Pizza Poppa |
 | Ross Marquand als Ultron (voice) |
 | Andy Bale als Memory Lane Salesperson (voice) |
 | Ako Mitchell als Charlie |
 | Momo Yeung als Hong Kong Master |
 | Daniel Swain als London Master |
 | Topo Wresniwiro als Master Hamir |
| Eden Nathenson als Ariann |
| Vinny Moli als Vinny |
| Charlie Norton als The Weasel |
| Aliyah Camacho als Young America Chavez |
| Ruth Livier als Elena Chavez |
| Chess Lopez als Amalia Chavez |
 | David Tse als Kamar-Taj Teacher |
| Yasmin Chadwick als Rag Tag #1 |
| Anthony Knight als Rag Tag #2 |
| Nuakai Aru als Shield Bearer #1 |
| Victoria Grove als Shield Bearer #2 |
 | Joshua Peace als NY Passerby 616 |
| Nina Jalava als Doctor Strange Fan |
| Joshmaine Joseph als Gargantos Fight Spectator #1 |
| Yenifer Molina als Gargantos Fight Spectator #2 |
| Kevin Dalton als Christine's Father |
| Orphee Sidibe als Bio Room Staff #1 |
| Gregory Fung als Bio Room Staff #2 |
 | Cecilia Appiah als Waitress |
| Victoria Sterling als Rag Tag Student |
| Jordan Alexandra als Office Worker |
| Bobbie Little als Scared Woman #1 |
| Gabriella Cooper-Parsons als Scared Woman #2 |
| André Layne als Sanctuary Guard |
 | Michael Waldron als Charlie's Best Man |
 | Bridget Hoffman als Soul of the Damned (voice) |
 | Scott Spiegel als Soul of the Damned (voice) |
| Jessica Pennington als Soul of the Damned (voice) |
 | Andrew Morgado als Soul of the Damned (voice) |
 | Audrey Wasilewski als Soul of the Damned (voice) |
| Christian Rummel als Soul of the Damned (voice) |
| Richie Palmer als Soul of the Damned (voice) |
| Danny Elfman | Original Music Composer |
| John Mathieson | Director of Photography |
| Sarah Halley Finn | Casting |
| Sam Raimi | Director |
| Stan Lee | Characters |
| Steve Ditko | Characters |
| Bob Murawski | Editor |
| Kevin Feige | Producer |
| Juan Peralta | Sound Re-Recording Mixer |
| Helen Pollak | Unit Production Manager |
| Helen Pollak | Line Producer |
| Julian Ashby | Art Direction |
| Jack Kirby | Thanks |
| Joe Simon | Thanks |
| Dave Jordan | Music Supervisor |
| Tia Nolan | Editor |
| Charles Wood | Production Design |
| Scott Derrickson | Executive Producer |
| Louis D'Esposito | Executive Producer |
| Victoria Alonso | Executive Producer |
| Gerry Conway | Thanks |
| John Romita Jr. | Thanks |
| Roy Thomas | Thanks |
| Jim Lee | Thanks |
| Brian K. Vaughan | Thanks |
| Matt Fraction | Thanks |
| Chris Claremont | Thanks |
| Mike Stallion | Art Direction |
| Samuel Le | Stunt Coordinator |
| Gene Colan | Thanks |
| Mitchell Bell | Co-Producer |
| John Bush | Set Decoration |
| Sarah Stuart | Assistant Art Director |
| John Byrne | Thanks |
| John Romita, Sr. | Thanks |
| David Michelinie | Thanks |
| Steven Grant | Thanks |
| Bryan Andrews | Thanks |
| Mike Ploog | Thanks |
| Joe Casey | Thanks |
| Nicky Barron | Set Costumer |
| Graham Churchyard | Costume Design |
| Thomas Brown | Supervising Art Director |
| Mark Swain | Art Direction |
| Lora Hirschberg | Sound Re-Recording Mixer |
| Addison Teague | Supervising Sound Editor |
| Steve Englehart | Thanks |
| Brian Michael Bendis | Thanks |
| Cyndi Ochs | Visual Effects Producer |
| Janek Sirrs | Visual Effects Supervisor |
| Pamela Waggoner | Set Costumer |
| Charlotte Hayward | Makeup Artist |
| Katy Wood | Supervising Sound Editor |
| Jamie Hallett | Visual Effects Supervisor |
| Jamie Christopher | Executive Producer |
| Dominic Fysh | First Assistant Director |
| Oliver Carroll | Art Direction |
| Darrin Denlinger | Storyboard Artist |
| Al Milgrom | Thanks |
| Jo McLaren | Stunt Coordinator |
| Aoife Warren | Assistant Art Director |
| Denise Ball | Set Designer |
| Eric Hauserman Carroll | Executive Producer |
| Jeremy Simser | Storyboard Artist |
| Joel Behrens | Visual Effects Supervisor |
| Brycen Counts | Stunt Coordinator |
| Chloe Reynolds | Set Costumer |
| Andy Park | Conceptual Illustrator |
| Bill Mantlo | Thanks |
| David Allcock | Storyboard Artist |
| Roger Stern | Thanks |
| Tessa Phillips | Set Costumer |
| Patrick Harris | Art Direction |
| Russell Hopwood | Visual Effects |
| Birgitta Fredlund | Costume Supervisor |
| Richard Gould | Sound Effects Editor |
| Tara Ilsley | Assistant Art Director |
| Matt Hancock | Set Dresser |
| Richie Palmer | Co-Producer |
| Michael Waldron | Writer |
| Richard Usher | Standby Art Director |
| Meagan Chancellor | VFX Artist |
| Steve Epting | Thanks |
| Paola Magrans | Sound Effects Editor |
| Rupert Hancock | Set Dresser |
| Amy Herring | Art Department Assistant |
| Austin Huntley | Art Department Assistant |
| Pete Thompson | Concept Artist |
| Eric Yamamoto | Storyboard Artist |
| Soren Bendt Aaboe Pedersen | Storyboard Artist |
| Bob Cheshire | Concept Artist |
| Karl Caffrey | Unit Production Manager |
| David Finch | Thanks |
| Reetu Aggarwal | VFX Artist |
| Nina Jalava | Stand In |
| Alex Smith | Art Direction |
| Alexander Ha | VFX Artist |
| Jonathan Maris | Storyboard Artist |
| James Flanagan | Set Dresser |
| Richard Howell | Thanks |
| Jakub Vykoukal | Concept Artist |
| Paul Chandler | Concept Artist |
| Thomas du Crest | Concept Artist |
| Mark Gruenwald | Thanks |
| Jörundur Rafn Arnarson | Visual Effects Supervisor |
| Kieron Gillen | Thanks |
| Jamie McKelvie | Thanks |
| Daniel Hazeltine | VFX Artist |
| Jonathan Hickman | Thanks |
| Winslow Mortimer | Thanks |
| Jean Thomas | Thanks |
| Daniel Edery | VFX Artist |
| Sally Crawshaw | Makeup Artist |
| Gina Cimmelli | Set Dresser |
| Kent Gordon | Thanks |
| Chris Warner | Thanks |
| Sarah Greenslade | Art Department Coordinator |
| Megan Clough-Ambridge | Art Department Assistant |
| Peter Alberti | Stand In |
| Becky Tun Pe | Stand In |
| Frank Brunner | Thanks |
| Alan Davis | Thanks |
| Terry Dodson | Thanks |
| Nick Dragotta | Thanks |
| Peter B. Gillis | Thanks |
| Marcos Martín | Thanks |
| Steve McNiven | Thanks |
| Yong Montaño | Thanks |
| Marie Severin | Thanks |
| Dave Thorpe | Thanks |
| JC Lee | Thanks |
