 | Michael Douglas als Dr. Nathan Conrad |
 | Sean Bean als Patrick Koster |
 | Brittany Murphy als Elisabeth Burrows |
 | Skye McCole Bartusiak als Jessie Conrad |
 | Guy Torry als Dolen |
 | Jennifer Esposito als Det. Sandra Cassidy |
 | Famke Janssen als Aggie Conrad |
 | Oliver Platt als Dr. Louis Sachs |
 | Shawn Doyle als Russel Maddox |
 | Victor Argo als Sydney Simon |
 | Conrad Goode als Max Dunlevy |
 | Paul Schulze als Jake |
 | Lance Reddick als Arnie |
 | Aidan Devine als Leon Edward Croft |
 | Alex Campbell als Jonathan |
 | Philip DeWilde als Intern |
 | Sam Montesano als Frankie |
 | Arlene Duncan als Aide |
| Judy Sinclair als Zelda Sinclair |
 | Larry Block als Doorman |
 | David Warshofsky als Ryan |
| Darren Frost als Janitor |
 | Philip Williams als Large Cop |
 | Louis Vanaria als Cop at Scene |
 | Daniel Kash als Detective Garcia |
 | Lucie Laurier als Vanessa |
 | Isabella Fink als 8-Year-Old Elisabeth |
 | Ray Iannicelli als Man at Marina |
| Colm Magner als Cop #1 |
 | Cyrus Farmer als Officer #1 |
 | Martin Roach als Transit Cop |
 | Patricia Mauceri als Sofia |
| Tony Bruno als Radio Host (uncredited) |
 | Paul J.Q. Lee als Man with a Cell Phone (uncredited) |
 | Lorli Villanueva als Chinese Woman (uncredited) |
| Gary Fleder | Director |
| Anthony Peckham | Screenplay |
| Patrick Smith Kelly | Screenplay |
| Anne Kopelson | Producer |
| Arnold Kopelson | Producer |
| Arnon Milchan | Producer |
| Bruce Berman | Executive Producer |
| Jeffrey Downer | Executive Producer |
| William Steinkamp | Editor |
| Armen Minasian | Editor |
| Amir Mokri | Director of Photography |
| David E. Russo | Additional Music |
| Avy Kaufman | Casting |
| Nelson Coates | Production Design |
| Dennis Davenport | Art Direction |
| Carolyn A. Loucks | Set Decoration |
| Cori Burchell | Costume Supervisor |
| Prudence Emery | Unit Publicist |
| Elizabeth Ludwick-Bax | Script Supervisor |
| Nana Greenwald | Co-Producer |
| Andrew Klavan | Co-Producer |
| Mark Isham | Original Music Composer |
| Chris Regan | Color Timer |
| Beth Gilinsky | Art Department Coordinator |
| David G. Fremlin | Assistant Art Director |
| Bill Harman | Construction Coordinator |
| Terry McGauran | Greensman |
| Carlos Caneca | Leadman |
| Michael Hartel | Location Scout |
| Michael Shocrylas | Set Designer |
| Cheryl Ladrillo | Standby Painter |
| Jeffery J. Tufano | Additional Camera |
| Ericson Core | Additional Photography |
| Ren Messer | First Assistant Camera |
| Gary Kangrga | Grip |
| Tim Merkel | Steadicam Operator |
| Ava Gerlitz | Still Photographer |
| John Glaser | Assistant Costume Designer |
| James D. Brown | Hairstylist |
| Linda Dowds | Makeup Artist |
| Graham Macpherson | Carpenter |
| Deanna Longley | Craft Service |
| Derek Becker | Makeup Effects |
| Glenn Hughes | Picture Car Coordinator |
| Ian Nelmes | Scenic Artist |
| Wayne Petrucelli | Security |
| Philip Douglas | Set Production Assistant |
| Rick Forsayeth | Stunt Coordinator |
| Kenny Alexander | Stunts |
| Mitch Goldstrom | Systems Administrators & Support |
| Mo Fitzgerald | Transportation Co-Captain |
| Michael Fennimore | Transportation Coordinator |
| John A. Machione | Unit Production Manager |
| Glenn D. Bloom | Video Assist Operator |
| Martha Pinson | Script Supervisor |
| Brett Lavinthal | First Assistant Editor |
| Jeff Enneking | Best Boy Electric |
| Gordon Eldridge | Electrician |
| Victor Abbene | Gaffer |
| Joseph Grimaldi | Rigging Gaffer |
| Zoe Abbott | Casting Associate |
| Nicholas Bernstein | Location Manager |
| Joe Hartwick Jr. | Production Accountant |
| Cyndi Brenner | Production Coordinator |
| Brian Leslie Parker | Production Manager |
| Frank Graziadei | Boom Operator |
| Branden Spencer | First Assistant Sound Editor |
| Michael K. Bauer | Music Editor |
| Peter Afterman | Music Supervisor |
| Ken Kugler | Orchestrator |
| Wade Wilson | Sound Editor |
| Randy Kelley | Sound Effects Editor |
| Gary Alper | Sound Mixer |
| Ron Bartlett | Sound Re-Recording Mixer |
| Scott Martin Gershin | Supervising Sound Editor |
| Lloyd Lee Barnett | Digital Compositors |
| Ian Hunter | Visual Effects Supervisor |
| Grant Lucibello | Second Assistant Director |
| Henry Jesiak | Assistant Property Master |
| David Jaquest | Set Dresser |
| Deborah Ross | Title Designer |
| Sarah Warland | Camera Loader |
| Ron Renzetti | Dolly Grip |
| Mike Kirilenko | Key Grip |
| Carole Cowley | Digital Effects Producer |
| Al Cerullo | Pilot |
| Michael Zimbrich | First Assistant Director |
| Tyler Delben | Third Assistant Director |
| Gary Burritt | Negative Cutter |
| Cristin L. Cornett | Assistant Production Coordinator |
| Michael Minkler | Additional Sound Re-Recording Mixer |
| Joe Schiff | ADR Editor |
| Craig S. Jaeger | Foley Editor |
| James Thatcher | Musician |
| Renée Tondelli | Supervising ADR Editor |
| Rick Newsome | Storyboard Designer |
| Dorota Zajac | Assistant Makeup Artist |
| Bridget O'Neill | Special Effects Makeup Artist |
| Greg White | Second Second Assistant Director |
| Tom Priestley Jr. | Second Unit Director |
| Gilbert Demers | Second Assistant Art Director |
| Tom Shaughnessey | Set Supervisor |
| Paul Berta | Storyboard Artist |
| Greg Steele | ADR Mixer |
| Henry Godding Jr. | ADR Recordist |
| James Moriana | Foley Artist |
| Nerses Gezalyan | Foley Mixer |
| Greg Zimmerman | Foley Recordist |
| Barry Williams | Visual Effects Editor |
| Walter Masko | Stunt Double |
| Michael Ryan | Best Boy Grip |
| Mara Galus | Camera Loader |
| Patrick Buchanan | Camera Trainee |
| Ronald Burke | Dolly Grip |
| Nicole Blanchard | Second Assistant Camera |
| James W. Swift | Wardrobe Assistant |
| Marc Griffin | Assistant Editor |
| David McIlroy | Assistant Location Manager |
| Currie Person | Location Assistant |
| Michael Harland | Location Production Assistant |
| Ken Kugler | Conductor |
| Jessica Clements | Music Coordinator |
| Kevin Clark | Catering |
| Clare Piller | Clearances Coordinator |
| Scott Beverly | Effects Supervisor |
| Jane Rogers | Extras Casting |
| Driss Tijani | Extras Casting Assistant |
| Daniel Horvath | First Assistant Accountant |
| Michael Plant | Generator Operator |
| Bernie Lalonde | Key Rigging Grip |
| Susan Haldenby | Medical Consultant |
| Christopher Comrie | Payroll Accountant |
| Kent Hayward | Production Assistant |
| Matthew Gross | Production Executive |
| Heather Anderson | Production Secretary |
| Amy Comstock | Second Assistant Accountant |
| Terry McAllister | Security Coordinator |
| Christopher Geggie | Property Master |
| Richard Dwan Jr. | Dialogue Editor |
| Rebecca Stoneham | Stunts |
| Jennifer Lamb | Stunts |
| Mary Ann Stevens | Stunts |
| Sue Parker | Stunts |
| C.J. Lusby | Stunts |
| Gary Archer | Prosthetics |
| Ellen Mirojnick | Costume Designer |
| Andrew Klavan | Book |
| Michael Runyard | Stunt Coordinator |
