 | Jim Carrey als Grinch |
 | Taylor Momsen als Cindy Lou Who |
 | Jeffrey Tambor als Mayor Augustus Maywho |
 | Christine Baranski als Martha May Whovier |
 | Bill Irwin als Lou Lou Who |
 | Molly Shannon als Betty Lou Who |
 | Clint Howard als Whobris |
 | Josh Ryan Evans als 8-Year-Old Grinch |
 | Mindy Sterling als Clarnella |
 | Bryce Dallas Howard als Surprised Who |
 | Lacey Kohl als Christina Whoterberry |
 | Rachel Winfree als Rose |
 | Rance Howard als Elderly Timekeeper |
 | Jeremy Howard als Drew Lou Who |
 | T.J. Thyne als Stu Lou Who |
 | Nadja Pionilla als Junie |
 | Jim Meskimen als Officer Wholihan |
 | Michael Dahlen als Customer |
 | David Costabile als Biker Who |
 | Mary Stein als Miss Rue Who |
 | James Ritz als Crazy Mose |
 | Deep Roy als Post Office Clerk |
 | Jessica Sara als Sophie |
| Mason Lucero als Who Boy |
 | Ben Bookbinder als 8-Year-Old Augustus Maywho |
 | Michaela Gallo als Who Schoolgirl |
 | Landry Allbright als 8-Year-Old Martha May Whovier |
 | Reid Kirchenbauer als 8-Year-Old Whobris |
 | Rebecca Chace als Shopper |
 | Suzanne Krull als Shopper |
 | Steve Kehela als Shopper |
 | Lillias White als Shopper |
 | Rain Pryor als Shopper |
 | John Alexander als Shopper |
 | Kevin Isola als Tree Trimmer |
 | Gavin Grazer als Yodeler |
 | Walter Franks als Clerk |
 | Verne Troyer als Band Member |
| Clayton Martinez als Cook |
 | Q'orianka Kilcher als Little Choir Member |
 | Caroline Williams als Tiny Who Woman |
 | John Short als Tiny Who Man |
| Grainger Esch als Near Miss Who |
| Eva Burkley als Pudding Chef |
 | Rick Baker als Puppeteer |
| Bill Sturgeon als Puppeteer |
 | Mark Setrakian als Puppeteer |
| Jurgen Heimann als Puppeteer |
 | Tim Blaney als Puppeteer |
 | Charles Croughwell als Balloon Who |
 | Frank Welker als Max the Dog (voice) |
 | Anthony Hopkins als Narrator (voice) |
| James Horner | Original Music Composer |
| Brian Grazer | Producer |
| Ron Howard | Producer |
| Mike Hill | Editor |
| Donald Peterman | Director of Photography |
| Todd Hallowell | Executive Producer |
| Daniel P. Hanley | Editor |
| Ve Neill | Makeup Artist |
| Jeffrey Price | Screenplay |
| Ron Howard | Director |
| Peter S. Seaman | Screenplay |
| Rachel Wyn Dunn | Compositors |
| Barry E. Jackson | Conceptual Design |
| Bill Corso | Makeup Artist |
| Allen Hall | Special Effects Coordinator |
| Nina Paskowitz | Hairstylist |
| Leslie Park | Script Supervisor |
| Kevin Scott Mack | Visual Effects Supervisor |
| Rita Ryack | Costume Design |
| Michael Corenblith | Production Design |
| Merideth Boswell | Set Decoration |
| Gail Rowell-Ryan | Key Hair Stylist |
| Rick Baker | Makeup Effects Designer |
| Michael Key | Makeup Artist |
| Bob Camp | Storyboard Artist |
| Jane Jenkins | Casting Director |
| Janet Hirshenson | Casting Director |
| Bonnie Greenberg | Music Supervisor |
| Aldric La'Auli Porter | Associate Producer |
| Louisa Velis | Associate Producer |
| David Womark | Associate Producer |
| Dr. Seuss | Book |
| David Womark | Unit Production Manager |
| Aldric La'Auli Porter | First Assistant Director |
| David Hyman | Second Assistant Director |
| Kurt Williams | Visual Effects Producer |
| Linda Fields | Associate Producer |
| Charles Croughwell | Stunt Coordinator |
| Todd Hallowell | Second Unit Director |
| Dan Webster | Supervising Art Director |
| Lauren E. Polizzi | Art Direction |
| Dan Bronson | Costume Supervisor |
| Toni G | Makeup Department Head |
| Kazu Hiro | Makeup Artist |
| Patricia Miller | Key Hair Stylist |
| David MacMillan | Production Sound Mixer |
| Mike Anderson | Key Grip |
| Kurt Williams | Visual Effects Supervisor |
| Julian Levi | Visual Effects Producer |
| Debra Wolff | VFX Editor |
| Joyce Cox | Visual Effects Producer |
| Michael J. Malone | Location Manager |
| Scott A. Hecker | Supervising Sound Editor |
| Eric A. Norris | Sound Effects Editor |
| Brian Thomas Nist | Sound Effects Editor |
| Kenneth L. Johnson | Sound Effects Editor |
| Michael Geisler | Sound Effects Editor |
| Christopher Flick | Foley Editor |
| Joe E. Rand | Music Editor |
| Jim Henrikson | Music Editor |
| John LaSalandra | Music Editor |
| Deborah Rutherford | Makeup Artist |
| Ben Folds | Songs |
| Barenaked Ladies | Songs |
| Busta Rhymes | Songs |
| Steven Page | Songs |
| Ed Robertson | Songs |
| Steve Harwell | Songs |
| Greg Camp | Songs |
| Paul O'Neill | Songs |
| Robert Kinkel | Songs |
| Jon Oliva | Songs |
| Mark Oliver Everett | Songs |
| Mariah Carey | Songs |
| James Horner | Songs |
| Faith Hill | Songs |
| Lisa Hoyle | Stunt Double |
| Lou Pecora | Compositing Artist |
