 | Robert Downey Jr. als Peter Highman |
 | Zach Galifianakis als Ethan Tremblay |
 | Michelle Monaghan als Sarah Highman |
 | Jamie Foxx als Darryl |
 | Juliette Lewis als Heidi |
 | Danny McBride als Lonnie |
 | RZA als Airport Screener |
 | Matt Walsh als TSA Agent |
 | Brody Stevens als Limo Driver |
 | Jakob Ulrich als Patrick |
| Naiia Ulrich als Alex |
 | Todd Phillips als Barry |
 | Bobby Tisdale als Carl |
 | Sharon Conley als Airport X-Ray |
| Nathalie Fay als Flight Attendant |
 | Emily Wagner als Flight Attendant |
 | Steven M. Gagnon als Air Marshall |
 | Paul Renteria als Border Guard |
 | Marco Rodríguez als Federali Agent |
 | Mimi Kennedy als Sarah's Mom |
 | Tymberlee Hill als New Mother |
 | Keegan-Michael Key als New Father |
 | Aaron Lustig als Dr. Greene |
 | Charlie Sheen als Charlie Harper |
 | Jon Cryer als Alan Harper |
| Haji Abdullah als Airport Passenger (uncredited) |
 | Jeremy Ambler als TSA Agent (uncredited) |
 | Madeline Brumby als Airport Pedestrian (uncredited) |
| Joseph Harold als Private Johnson (uncredited) |
 | Sarah Reagin als Airport Security Agent (uncredited) |
| Todd Phillips | Director |
| Todd Phillips | Screenplay |
| Alan R. Cohen | Screenplay |
| Alan Freedland | Screenplay |
| Adam Sztykiel | Screenplay |
| Susan E. Novick | Post Production Supervisor |
| Christophe Beck | Original Music Composer |
| Debra Neil-Fisher | Editor |
| Lawrence Sher | Director of Photography |
| Bill Brzeski | Production Design |
| Seth Yanklewitz | Casting |
| Juel Bestrop | Casting |
| Louise Mingenbach | Costume Design |
| Danielle Berman | Set Decoration |
| Desma Murphy | Art Direction |
| Clint Wallace | Art Direction |
| Christopher Isenegger | Art Department Coordinator |
| Karen Golden | Script Supervisor |
| Jeanne Byrd | Script Supervisor |
| Melinda Sue Gordon | Still Photographer |
| Alan Freedland | Story |
| Alan R. Cohen | Story |
| Susan Downey | Executive Producer |
| Scott Budnick | Executive Producer |
| Thomas Tull | Executive Producer |
| Todd Phillips | Producer |
| Daniel Goldberg | Producer |
| Jeffrey Wetzel | Co-Producer |
| David Witz | Co-Producer |
| Joseph Garner | Associate Producer |
| José Antonio García | Sound mixer |
| Cameron Frankley | Sound Designer |
| Cameron Frankley | Supervising Sound Editor |
| Ron Bartlett | Sound Re-Recording Mixer |
| Doug Hemphill | Sound Re-Recording Mixer |
| Ai-Ling Lee | Sound Effects Editor |
| Ai-Ling Lee | Sound Designer |
| Jason W. Jennings | Sound Effects Editor |
| Jason W. Jennings | Sound Designer |
| Jonathan Fuh | Boom Operator |
| George Drakoulias | Music Supervisor |
| Randall Poster | Music Supervisor |
| Fernand Bos | Music Editor |
| Andrew Silver | Music Editor |
| Julie Pearce | Music Editor |
| Mark Swenson | Production Coordinator |
| David Witz | Unit Production Manager |
| Mark Scoon | Executive In Charge Of Production |
| Allan Graf | Stunt Coordinator |
| Daniel C. Gold | Camera Operator |
| Tommy Lohmann | Camera Operator |
| Luke Kalteux | Lighting Technician |
| Tim Mikulecky | Stunts |
| David A. Arnold | Dialogue Editor |
| David V. Butler | Supervising Dialogue Editor |
| Benjamin Beardwood | Dialogue Editor |
| Shepherd Frankel | Supervising Art Director |
| Petra Bach | ADR Supervisor |
| Mychael Bates | Property Master |
| Michael P. Sweeney | Assistant Property Master |
| Grady Allen Bishop | Camera Car |
| Maria Baker | Art Direction |
| Merribelle Anderson | Key Hair Stylist |
| Jennifer Bell | Hair Department Head |
| John Blake | Makeup Artist |
| Richard Boggs | Hairstylist |
| Vanessa Davis | Hairstylist |
| LaLette Littlejohn | Makeup Artist |
| Deidra Dixon | Hairstylist |
| Yvette Meely | Additional Hairstylist |
| Joseph Regina | Makeup Artist |
| Keith Sayer | Key Makeup Artist |
| Janeen Schreyer | Makeup Department Head |
| Christopher Trujillo | Makeup Artist |
| Dawn Turner | Hairstylist |
| Dionne Wynn | Makeup Artist |
| Jessie Graff | Stunts |
| Mark De Alessandro | Stunts |
| Doug Coleman | Stunt Driver |
| Merritt Yohnka | Stunts |
| Gregory J. Barnett | Stunts |
| Jeffrey J. Dashnaw | Stunts |
| Marilyn Giacomazzi | Stunts |
| Allan Graf | Second Unit Director |
| Scott Wilder | Stunts |
| Matt Leonard | Stunts |
| Joanna Shelmidine | Stunt Driver |
| Danny Wynands | Stunts |
| Al Goto | Stunt Driver |
| Joe Bucaro III | Stunt Driver |
| Ed Duran | Stunt Driver |
| Steve Kelso | Stunt Driver |
| Tom Elliott | Stunt Driver |
| Angelique Midthunder | Stunt Driver |
