 | Jim Carrey als Lloyd Christmas |
 | Jeff Daniels als Harry Dunne |
 | Laurie Holden als Adele |
 | Rachel Melvin als Penny |
 | Kathleen Turner als Fraida |
 | Rob Riggle als Travis / Captain Lippincott |
 | Tembi Locke als Dr. Walcott |
 | Paul Blackthorne als Emergency Room Doctor |
 | Brady Bluhm als Billy |
 | Patricia French als Ms. Sourpuss |
 | Steve Tom als Dr. Pinchelow |
 | Don Lake als Dr. Meldman |
 | Eddie Shin als Gordy |
 | Atkins Estimond als Gus |
 | Tommy Snider als Tom |
 | Lindsay Ayliffe als Professor Garabedian |
 | Matthew Cardarople als Inventor No. 1 |
 | Bill Murray als Ice Pick |
 | Grant James als Mr. Stainer |
 | Taylor St. Clair als Mrs. Steiner |
 | Erin Allin O'Reilly als Asylum Nurse No. 1 |
 | Walt Arnett als KEN Audience Member |
 | Erika Bierman als Fanny at Age 13 |
 | Kassidy Claire als Fanny at Age 5 |
 | Carly Craig als Young Fraida |
| Bryan Dilbeck als Dr. Dilbeck |
 | Dalton E. Gray als Young Harry |
| Michael McCrudden als Audience Member |
 | June Shannon als Harry's Trailer Park Wife |
 | Maia Moss-Fife als Receptionist |
 | Jeff Sumner als Convention Official |
 | Julius Sharpe als KEN Conference Attendee |
| Dave Walpole als KEN Conference Attendee |
 | Elizabeth Cooper als Mrs. Julie James |
 | Michael Yama als Harry's Dad |
| Nancy Byers Farrelly als Asylum Nurse #2 |
| Derek Holland als Asylum Patient |
| Brendan Boyle als Asylum Patient |
 | Swizz Beatz als Ninja Leader |
 | Mike Cerrone als Trucker |
 | Sean Gildea als Trucker's Pal |
 | Brett Wyman als Inventor #2 |
 | Jo Helton als Mrs. Snergle |
 | Edward Barbanell als Nursing Home Orderly |
| Mariann Neary als Farmer's Wife |
| John Imlay als Farmer |
 | Jon Barinholtz als Inventor No. 3 |
| Lucas Daniels als Bartender |
| Carter Hicks als Bus Kid |
| Baxter Cooper Rogers als Prom Date |
 | Sandra Dorsey als Stuffy Woman |
 | Arielle Liberman als Emergency Room Nurse |
| Jon Barry als Emergency Room Orderly |
| Jesse Gines als Emergency Room Orderly |
| Robin O'Neal Sorensen als Emergency Medical Technician #1 |
| Chris Randall Sorensen als Emergency Medical Technician #2 |
 | Daniel Greene als Wheelchair Ninja |
| Will Coogan als Room Service Waiter |
| Caryle Seim als Trailer Grandma |
 | Danny Murphy als Joystick Victim |
| Paul Bednarz als KEN Convention Employee (uncredited) |
| Jennifer Cocker als Young Inventor (uncredited) |
| John Deifer als Mental Patient (uncredited) |
 | Gregory Fears als Man at Gas Station (uncredited) |
| Abigail Gamache als Prom Attendee (uncredited) |
| William Goodrum als Prom Singer (uncredited) |
 | Walter Hendrix III als Street Patron (uncredited) |
 | Angela Kerecz als Waitress (uncredited) |
 | John Merical als Neighbor (uncredited) |
 | Rhomeyn Johnson als Bus Driver |
 | Nancy Yee als Harry's Mom |
| Peter Farrelly | Director |
| Bobby Farrelly | Director |
| Bennett Yellin | Writer |
| John Morris | Writer |
| Sean Anders | Writer |
| Riza Aziz | Producer |
| Steven Stabler | Executive Producer |
| Joey McFarland | Producer |
| Steven Rasch | Editor |
| David Koplan | Executive Producer |
| Peter Farrelly | Writer |
| Bobby Farrelly | Writer |
| Matthew F. Leonetti | Director of Photography |
| Peter Farrelly | Producer |
| Charles B. Wessler | Producer |
| Bradley Thomas | Producer |
| Mike Cerrone | Writer |
| Danny Dimbort | Executive Producer |
| Brad Krevoy | Executive Producer |
| Christian Mercuri | Executive Producer |
| Aaron Osborne | Production Design |
| Bobby Farrelly | Producer |
| Rick Montgomery | Casting |
| Marc S. Fischer | Executive Producer |
| Bill Corso | Makeup Artist |
| Empire of the Sun | Music |
| Karen Patch | Costume Design |
| J.B. Rogers | Co-Producer |
| Linda Fields | Associate Producer |
| Ellen Dumouchel | Associate Producer |
| Tom Wolfe | Music Supervisor |
| Manish Raval | Music Supervisor |
| Marc S. Fischer | Unit Production Manager |
| J.B. Rogers | First Assistant Director |
| Greg Guzik | Second Assistant Director |
| Tierre Turner | Stunt Coordinator |
| Erin Cochran | Art Direction |
| Jennifer M. Gentile | Set Decoration |
| Danny Brown | Assistant Art Director |
| Sean Ryan Jennings | Assistant Art Director |
| Michael Sabo | Property Master |
| Shawn M. Gray | Assistant Property Master |
| Hopper Stone | Still Photographer |
| John S. Moyer | "A" Camera Operator |
| John S. Moyer | Steadicam Operator |
| Paul Varrieur | "B" Camera Operator |
| Mark Santoni | First Assistant Camera |
| Jeffrey N. Civa | First Assistant Camera |
| Ross Davis | Second Assistant Camera |
| Trey Twitty | Second Assistant Camera |
| Mary H. Ellis | Sound Mixer |
| Bartek Swiatek | Sound Mixer |
| James Peterson | Boom Operator |
| Thomas Doolittle | Utility Sound |
| Amir R. Khan | Second Second Assistant Director |
| Martin Kitrosser | Script Supervisor |
| Allison Furgal | Production Coordinator |
| Kelly Mokris | Assistant Production Coordinator |
| Ilana McAllistor | Production Accountant |
| Stephen Crowley | Gaffer |
| Steve Zigler | Rigging Gaffer |
| Kerry Rawlins | Key Grip |
| Mackie Roberts | Best Boy Grip |
| C. Ashley Sudge | Dolly Grip |
| Chris D. Chapman | Dolly Grip |
| Maida N. Morgan | Location Manager |
| Erinn Knight | Assistant Costume Designer |
| Danielle Baker | Costume Supervisor |
| Robert Lucas | Leadman |
| Ron Hammond | Set Decorating Coordinator |
| Stacie McKinnon | Art Department Coordinator |
| Haley Keim | Graphic Designer |
| Kimberly Jones | Makeup Department Head |
| Lay'Na Anderson | Key Makeup Artist |
| Kelly Muldoon | Hair Department Head |
| Lawrence Davis | Key Hair Stylist |
| Andrea C. Brotherton | Hairstylist |
| Patrick Ingram | Extras Casting |
| Russell Tyrrell | Special Effects Supervisor |
| David H. Nash | Construction Coordinator |
| Dan Muscarella | Color Timer |
| George Mandl | Assistant Editor |
| David Raymond | Additional Editor |
| Debra Neil-Fisher | Additional Editor |
| Walter Volpatto | Digital Intermediate Colorist |
| Jeff Halsey | Digital Intermediate Producer |
| Paul Lavoie | Digital Intermediate Producer |
| Andrew DeCristofaro | Supervising Sound Editor |
| Kelly Oxford | Supervising Sound Editor |
| Michael Payne | Sound Designer |
| Joe Barnett | Sound Re-Recording Mixer |
| Marshall Garlington | Sound Re-Recording Mixer |
| Glynna Grimala | ADR Supervisor |
| David Stanke | First Assistant Sound Editor |
| Dan Hegeman | Sound Effects Editor |
| Kerry Ann Carmean | Foley Editor |
| Frederick H. Stahly | Dialogue Editor |
| Laura Harris Atkinson | Dialogue Editor |
| Tammy Fearing | Dialogue Editor |
| Nerses Gezalyan | Foley Mixer |
| Gary A. Hecker | Foley Artist |
| Gary Marullo | Foley Artist |
| Howard London | ADR Mixer |
| Brian Smith | ADR Mixer |
| Patty Connolly | ADR Voice Casting |
| Mark Sussman | ADR Voice Casting |
| John Heller | Visual Effects Supervisor |
| Aaron Becker | Title Designer |
| Erika Abrams | Visual Effects Producer |
| Alison Rosenfeld Moses | Music Coordinator |
| Jonathan Leahy | Music Coordinator |
| Tracy Keehn-Dashnaw | Stunts |
| John Cenatiempo | Stunts |
| Danny Wynands | Stunts |
| Sean Patrick Burke | Production Assistant |
