 | Henry Thomas als Elliott |
 | Drew Barrymore als Gertie |
 | Robert MacNaughton als Michael |
 | Peter Coyote als Keys |
 | Dee Wallace als Mary |
 | Erika Eleniak als Pretty Girl |
 | K.C. Martel als Greg |
 | C. Thomas Howell als Tyler |
 | Sean Frye als Steve |
 | David M. O'Dell als Schoolboy |
| Richard Swingler als Science Teacher |
| Frank Toth als Policeman |
| Robert Barton als Ultra Sound Man |
| Michael Darrell als Van Man |
| David Berkson als Medical Unit |
| David Carlberg als Medical Unit |
 | Milt Kogan als Medical Unit |
| Alexander Lampone als Medical Unit |
| Rhoda Makoff als Medical Unit |
| Robert Murphy als Medical Unit |
| Richard Pesavento als Medical Unit |
| Tom Sherry als Medical Unit |
| Susan Cameron als Medical Unit |
| Will Fowler Jr. als Medical Unit |
| Barbara Hartnett als Medical Unit |
| Diane Lampone als Medical Unit |
 | Mary Stein als Medical Unit |
| Mitch Suskin als Medical Unit |
 | Ted Grossman als Government Agent (uncredited) |
 | James Kahn als Mustachioed Medical Unit Member who confirms E.T.'s death (uncredited) |
 | Anne Lockhart als Nurse (uncredited) |
 | Melissa Mathison als Elliot's School Nurse (uncredited) |
 | Debra Winger als Nurse Zombie Carrying Poodle (uncredited) |
| Lori Randolph als Blonde little girl tricker or treater (uncredited) |
| John Williams | Original Music Composer |
| Leslie Butcher | Art Department Coordinator |
| Carlo Rambaldi | Special Effects |
| Robert Sidell | Makeup Artist |
| Richard E. Butler | Stunts |
| Steven Spielberg | Producer |
| Charles L. Campbell | Supervising Sound Editor |
| Carol Littleton | Editor |
| Mike Fenton | Casting |
| Marci Liroff | Casting |
| Jackie Carr | Set Decoration |
| Kathleen Kennedy | Producer |
| Jane Feinberg | Casting |
| Allen Daviau | Director of Photography |
| Dale L. Martin | Special Effects |
| Steven Spielberg | Director |
| Melissa Mathison | Screenplay |
| James D. Bissell | Production Design |
| Al Bailey | Visual Effects |
| Glenn Randall Jr. | Stunt Coordinator |
| Richard Vane | Location Manager |
| Dennis Muren | Visual Effects Supervisor |
| Carlo Rambaldi | Visual Effects |
| Frank Marshall | Production Supervisor |
| Melissa Mathison | Associate Producer |
| Katy Emde | First Assistant Director |
| Daniel Attias | Second Assistant Director |
| Glenn Randall Jr. | Second Unit Director |
| Esther Vivante | Script Supervisor |
| Bonne Radford | Production Accountant |
| Jane Goe | Assistant Accountant |
| Bruce McBroom | Still Photographer |
| Gene S. Cantamessa | Sound Mixer |
| James Plannette | Gaffer |
| Gene Kearney | Key Grip |
| Bob Munoz | Best Boy Grip |
| Donald L. Hartley | Dolly Grip |
| William James Teegarden | Set Designer |
| Russell Goble | Property Master |
| Deborah Lynn Scott | Costumer |
| Lola 'Skip' McNalley | Hairstylist |
| John Feinblatt | Transportation Captain |
| Ramon Pahoyo | Craft Service |
| Lyla Foggia | Unit Publicist |
| Kathleen Korth | First Assistant Editor |
| David Pettijohn | Sound Effects Editor |
| Louis L. Edemann | Sound Effects Editor |
| Richard C. Franklin | Sound Effects Editor |
| Samuel C. Crutcher | Sound Effects Editor |
| Hank Salerno | ADR Editor |
| Nicholas Korda | ADR Editor |
| Chuck Neely | Assistant Sound Editor |
| Kenneth Hall | Music Editor |
| Herbert W. Spencer | Orchestrator |
| Robert Knudson | Sound Re-Recording Mixer |
| Robert Glass | Sound Re-Recording Mixer |
| Don Digirolamo | Sound Re-Recording Mixer |
| Donah Bassett | Negative Cutter |
| Dennis Brookins | Negative Cutter |
| Robert Raring | Color Timer |
| Fred Lerner | Stunts |
| Bobby Porter | Stunts |
| Felix Silla | Stunts |
| Chuck Waters | Stunts |
| Bennie E. Dobbins | Stunts |
| Ted Grossman | Stunts |
| Robert Elswit | Visual Effects Camera |
