 | Millie Bobby Brown als Enola Holmes |
 | Henry Cavill als Sherlock Holmes |
 | Sam Claflin als Mycroft Holmes |
 | Helena Bonham Carter als Eudoria Holmes |
 | Louis Partridge als Lord Tewkesbury |
 | Adeel Akhtar als Lestrade |
 | Fiona Shaw als Miss Harrison |
 | Frances de la Tour als The Dowager |
 | Burn Gorman als Linthorn |
 | Susan Wokoma als Edith |
 | Claire Rushbrook als Mrs. Lane |
 | David Bamber als Sir Whimbrel |
 | Hattie Morahan als Lady Tewkesbury |
 | Gaby French als Seamstress |
 | Paul Copley als Station Master |
 | Ellie Haddington als Miss Gregory |
 | Alex Kelly als Miss Gregory II |
 | James Duke als Footman |
| Connor Catchpole als Gardener |
 | Sarah Flind als Tea Shop Assistant |
 | Dempsey Bovell als Fleet Street Hawker |
 | Neil Bell als Constable |
| Sofia Stavrinou als Young Enola |
| Sophie Dixon als Toddler Enola |
 | David Kirkbride als Agitator |
 | Delroy Atkinson als Porter |
 | Mary Roscoe als Grace Whitting |
 | Anthony Aje als Newspaper Boy (House of Lords) |
| Anthony Rickman als Newspaper Boy (Fleet Street) |
| Philip Scott-Wallace als Newspaper Editor |
| Tuyen Do als Boarding School Teacher |
| Esther Coles als Miss Fox |
 | Owen Atlas als Young Sherlock Holmes (uncredited) |
| Paul Parker als Police Inspector (uncredited) |
| Heather Pearse als Hawker (uncredited) |
 | Jay Simpson als Conductor (uncredited) |
| Millie Bobby Brown | Producer |
| Nancy Springer | Novel |
| Harry Bradbeer | Director |
| Jack Thorne | Screenplay |
| Michael Carlin | Production Design |
| Michael Dreyer | Executive Producer |
| Jina Jay | Casting |
| Paige Brown | Producer |
| Consolata Boyle | Costume Design |
| Adam Bosman | Editor |
| Daniel Pemberton | Original Music Composer |
| Mary Parent | Producer |
| Harry Bradbeer | Executive Producer |
| Giles Nuttgens | Director of Photography |
| Michael Dreyer | Unit Production Manager |
| Jack Ravenscroft | First Assistant Director |
| Joe Barlow | Second Assistant Director |
| Simon Fraser | Unit Production Manager |
| Jane Houston | Co-Producer |
| Ali Mendes | Producer |
| Joshua Grode | Executive Producer |
| Jo McLaren | Stunt Coordinator |
| Alex Garcia | Producer |
| Fizz Hood | Stunt Double |
| Hasit Savani | Stunt Double |
| Juliette Cheveley | Stunt Double |
| Ian Pead | Fight Choreographer |
| Choi Ho Man | Supervising Art Director |
| Martin Hitchcock | Art Direction |
| Andrew Munro | Art Direction |
| Ashley Winter | Art Direction |
| Nina Armstrong | Stunts |
| Matthew Bell | Stunts |
| Liam Coote | Stunts |
| Nicholas Daines | Stunts |
| Will Deville | Stunts |
| Nadia Hansell | Stunts |
| Sarah Lochlan | Stunts |
| Chus Lucas | Stunts |
| Kim McGarrity | Stunts |
| Adrian McGaw | Stunts |
| Ruth Nelson | Stunts |
| James O'Daly | Stunts |
| Shane Roberts | Stunts |
| Alli Ryan | Stunts |
| Luke Scott | Stunts |
| Marlow Warrington-Mattei | Stunts |
| Annabel Wood | Stunts |
| Giles Nuttgens | "A" Camera Operator |
| Lisa Chugg | Set Decoration |
| Lorna Houlihan | Assistant Art Director |
| Suzanna Smith | Assistant Art Director |
| Paul Edwards | Steadicam Operator |
| Paul Edwards | "B" Camera Operator |
| Ray Meere | First Assistant "A" Camera |
| Harry Wingate | Second Assistant "A" Camera |
| Spencer Murray | First Assistant "B" Camera |
| Alistair King | Second Assistant "B" Camera |
| Adam Shell | Digital Imaging Technician |
| Alex Bailey | Still Photographer |
| Jane Houston | Script Supervisor |
| Will Whale | Production Sound Mixer |
| Andy Cole | Gaffer |
| Dave Thom | Best Boy Electric |
| Alan Graham | Rigging Gaffer |
| Bernd Mayer | Key Grip |
| Mark Holt | Special Effects Supervisor |
| Aimee Watret | Special Effects Coordinator |
| Jess MacDonald | Location Manager |
| Roy Chapman | Property Master |
| Marion Weise | Costume Supervisor |
| Joanne Lees | Assistant Costume Designer |
| Bethany Cross | Costume Coordinator |
| Sian Grigg | Hair Designer |
| Sian Grigg | Makeup Designer |
| Carol Hemming | Hairstylist |
| Sarah Nuth | Makeup & Hair |
| Claudia Stolze | Makeup & Hair |
| Emanuele Giraldo | First Assistant Editor |
| Emma Zee | Post Production Supervisor |
| Helen Judd | Visual Effects Producer |
| Michael Bruce Ellis | Visual Effects Supervisor |
| Fiona Harper | Production Coordinator |
| Valentina König | Assistant Production Coordinator |
| Chris Bevan | Assistant Production Coordinator |
| Eleanor Coverdale | Assistant Production Coordinator |
| Jools Faiers | Graphic Designer |
| Sav Akyüz | Storyboard Artist |
| Molly Blake | Art Department Coordinator |
| Amandeep Rahi | Set Decoration Buyer |
| Olivia Brittain | Casting Associate |
| Rebecca Rossmaur | Casting Assistant |
| Catherine Garlick | Casting Assistant |
| Verity Naughton | Additional Casting |
| Penny Dyer | Dialect Coach |
| Nicola Graydon-Harris | Unit Publicist |
| Rob Harris | Unit Publicist |
| Nessa King | Production Accountant |
| Harry Skinner | Payroll Accountant |
| Nina Hartstone | Supervising Sound Editor |
| Eilam Hoffman | Supervising Sound Editor |
| Jens Rosenlund Petersen | Supervising Dialogue Editor |
| Amy Felton | Dialogue Editor |
| Samir Foco | Sound Designer |
| Tom Sayers | Sound Designer |
| Steve Browell | Sound Effects Editor |
| Louise Burton | Assistant Sound Editor |
| Mike Tehrani | ADR Mixer |
| Sue Harding | Foley Artist |
| Oliver Ferris | Foley Artist |
| Sophia Hardman | Foley Mixer |
| Dario Swade | Foley Editor |
| Maria Kelly | ADR Recordist |
| Warren Lever | Construction Manager |
| Sian Lyn-Jones | Construction Coordinator |
| David Beminster | Transportation Captain |
| Mason Durrell | Transportation Co-Captain |
| Rachel Bucknor | Unit Medic |
| Peter Talbot | Second Unit Director of Photography |
| Alison Litton | Music Supervisor |
| Peter Afterman | Music Supervisor |
| Jane Berry | Music Coordinator |
| Andrew Skeet | Orchestrator |
| Andrew Skeet | Conductor |
| Ben Smithers | Music Editor |
| Catherine Hébert | Visual Effects Supervisor |
| Matt Curtis | Title Designer |
| Pratik Chaudhari | Visual Effects |
| Markus Andreas | Sound Assistant |
| Tom Hannibal | Visual Effects Editor |
