 | Javier Bardem als Pablo Escobar |
 | Penélope Cruz als Virginia Vallejo |
 | Peter Sarsgaard als Shepard |
 | Julieth Restrepo als Maria Victoria Henao |
 | Óscar Jaenada als Santoro |
 | David Valencia als Santos |
 | Mark Basnight als Family Man |
 | Joavany Alvarez als Ignacio Velarde |
 | Matthew Moreno als Pablito |
 | David Ojalvo als FBI Agent |
 | Fredy Yate als Pelado |
 | Ricardo Niño als Careta |
| Pedro Calvo als Gatillero |
| Santiago Londoño als Hermosilla |
 | Juan Sebastián Calero als Carlos Corral |
| Quique Mendoza als Abel Monje |
 | Ariel Sierra als Salvador Martín |
| Julio Nava als Garza |
| Miguel Such als Victor |
 | Atanas Srebrev als Agent Holland |
| Carlos Ramírez als Juan Pablo (8 years) |
| Tania Valencia als Chantal |
| Erik Rodriguez als Boy from the Slums |
 | Sara Deray als Paula |
| Patrick Forster-Delmas als Producer |
 | Lillian Blankenship als Family Man's Daughter |
| Georgi Nikolov als Hitman #1 |
| Mihail Stoyanov als Hitman #2 |
 | Nathan Cooper als Cop #1 |
| Andrew De La Rocha als Cop #2 |
 | Colin Salmon als High State US Official |
| Santiago Soto als Ignacio Castro |
 | Bernardo García als Cali Delegate |
| Oscar Rodriguez als Campaign Manager |
| Simón Rivera als Rodrigo Lara Bonilla |
 | Carlos Manuel Vesga als La Plaga |
 | Álvaro García als Alfonso López Michelsen |
 | Catalina Londoño als Nurse |
| Pedro Ochoa als Doctor Panama Clinic |
| Douglas Ceballos als Judge Alarcón |
 | Francisco Bolívar als Gunman |
 | Luis Fernando Hoyos als Colonel Méndez |
 | Juan Pablo Gamboa als Director TV |
| Karine Amaya als Attractive Blonde Presenter |
| Andrea Vidal als Teenager |
 | Heisel Mora als Airline Employee |
| Emilia Klayn als Secretary |
 | Alejandro Ruiz als Soccer Announcer |
| Herbert King als Pawn Shop Attendant |
 | Ricardo Vélez als Surgeon |
| Nicolas Gonzales als Juan Pablo (Teenager) |
| Hannah L'Hoeste als Manuela (4 Years) |
| Manuel José Chaves als Samuel Elizondo |
 | Giselle Da Silva als Olguita Arranz |
| Juan David Agudelo als Puppy Dog |
 | Nina Caicedo als Woman |
| Jorge Monterrosa als Young Man |
| Juan Carlos Ortega als Locutor |
| Santiago Lozano als Hitman |
| Alberto Pablo Rivera als Family Man |
| Juan Castillo als Employee |
| Cristian Rojas als Judge Alarcón's Son (8 Years) |
| Juan Sábato als Operator 1 |
| Andrés Felipe Calero als News Anchor |
| Carlos Carvajal als Stage Manager |
 | Norma Nivia als Reporter |
 | Diego Landaeta als Phone Technician |
 | David Trejos als Passenger |
| Jorge Alberto Reyes als Janitor |
| Juan Angulo als Subordinate |
| Alexander Acosta-Osorio als Workers' Leader |
| Juan Vela als Worker |
| Mihail Rangelov als Monje Double |
| Plamen-Kaloyan Todorv als Hitman #3 |
| Philip Lind-Bendixen als US Marine Soldier |
 | Juan Camilo Castillo als Funeral Employee |
| Diana Wiswell als Nurse |
| Quique Mendosa als Abel Monje |
| Julio Navas als Garza |
| Jere Hausfater | Producer |
| Fernando León de Aranoa | Director |
| Álex Catalán | Director of Photography |
| Ana Lozano | Makeup Designer |
| Miguel Menéndez de Zubillaga | Producer |
| Fernando León de Aranoa | Writer |
| Loles García Galeán | Costume Design |
| Antonio Ordóñez | Assistant Director |
| Ed Cathell III | Producer |
| Dean Nichols | Producer |
| Guillermo Navajo | Assistant Director |
| Ramiro Sabell hijo | First Assistant Camera |
| Javier Bardem | Producer |
| Kalina Kottas | Producer |
| Todor Lazarov | Stunt Coordinator |
| Alain Baineé | Production Design |
| Selena Arizanovic | Music Supervisor |
| Virginia Vallejo | Book |
| Wanda Morales | Costume Design |
| Massimo Gattabrusi | Hair Designer |
| Peter Krumov | Carpenter |
| Ivo Velkov | Digital Imaging Technician |
| Gustavo Moyano | Casting Coordinator |
| Milena Georgieva | Production Accountant |
| Zahary Borisov | Assistant Sound Editor |
| Tapio Liukkonen | Foley Artist |
| Oleksii Moskalenko | Visual Effects Supervisor |
| María Clara López | Key Makeup Artist |
| Mark Sussman | ADR Voice Casting |
| Mauricio Martinez | Casting Assistant |
| Carolina Soto | Wardrobe Assistant |
| Catalina Giangrandi | Wardrobe Supervisor |
| Sandra Serna | Script Supervisor |
| Nikolay Bakalov | Foley Editor |
| Mike Duffy | Visual Effects Producer |
| Brian Hayashi | Post Production Supervisor |
| Laura Lopera | Art Department Coordinator |
| Nicolás Vélez Noguera | Extras Casting Coordinator |
| Vanya Benelinova | Visual Effects Coordinator |
| Sean Wheelan | Visual Effects Producer |
| Richard Baker | Visual Effects Supervisor |
| Iva Petkova | Location Manager |
| Rafa Lluch | Second Unit Director of Photography |
| Saioa Lara | Costume Supervisor |
| Omaira Olarte | Health and Safety |
| Violeta Piperevska | Production Coordinator |
| Juan Cortés | Music Programmer |
| Gord Hillier | Dialogue Editor |
| Felipe Siem | Lighting Artist |
| Christine Pyle | Visual Effects Coordinator |
| Iveta Tsvetkova | Visual Effects Coordinator |
| Simona Ilieva | Art Department Assistant |
| Jenny Arango | Costume Assistant |
| Jugatx Urabayen | Costume Assistant |
| Shiri Lerner | Production Coordinator |
| Jivko Chakarov | Post Production Supervisor |
| Melissa Villegas Solórzano | Set Decoration |
| Ivailo Tzvetkov | First Assistant Camera |
| Vasil Paunov | Second Assistant Camera |
| Ivelin Metodiev | Second Assistant Camera |
| Ana Obradors | Production Coordinator |
| Trevor Graciano | Compositing Supervisor |
| Nevena Dragoshinova | Visual Effects Editor |
| Isaac Heron | Visual Effects Editor |
| Nikolay Pachov | Visual Effects Editor |
| Javier Muñoz | Digital Imaging Technician |
| Valentina Arjona | Assistant Makeup Artist |
| Lulú Salgado | Assistant Set Decoration |
| Andrés Gurisatti | Property Master |
| Mihail Yanakiev | Camera Operator |
| Samuel Cig | Second Assistant Camera |
| Juanjo Sánchez | Steadicam Operator |
| Jhon Moyano | Casting Assistant |
| Ana Bernal | Assistant Costume Designer |
| Natalia Sabogal | Production Coordinator |
| Vladimir Kaloyanov | Sound Mixer |
| Bright Jani | Compositor |
| Iñigo Navarro | Art Direction |
| Cristian Espinosa Toro | Transportation Coordinator |
| Gustavo Gini | Orchestrator |
| Gord Hillier | Sound Re-Recording Mixer |
| Alba Rodriguez del Rio | Animation |
| Tovonaina Andriamampionona | Compositor |
| María José Almela | First Assistant Editor |
| César Abades | Special Effects Supervisor |
| Susana Jaramillo | Costume Assistant |
| Fernando Furones | Orchestrator |
| Kiril Kaloyanov | Boom Operator |
| Kristian Talajic | Visual Effects Supervisor |
| Ainhoa Eskisabel | Assistant Makeup Artist |
| Elynarco Garay | Key Grip |
| Andrés Gutiérrez | Steadicam Operator |
| Catherine Rodríguez | Assistant Costume Designer |
| Paola A. Holguin | Production Assistant |
| Biviana Márquez | Script Supervisor |
| Kaiser Thomas | Matte Painter |
| Ferrán Piquer | Visual Effects Coordinator |
| Jessie Rosbäck | Visual Effects Coordinator |
| Andrey Hristozov | Visual Effects Editor |
| Kiril Valchanov | Steadicam Operator |
| Chiky Serrano | Assistant Costume Designer |
| Belinda Uriegas | Production Coordinator |
| Avi Salem | Compositor |
| Michelle Ryan | Matte Painter |
| Maria Andrea Rangel | Set Decoration |
| David Parra | Video Assist Operator |
| Beba Yordanova | Production Assistant |
| Milena Mihaylova | Script Supervisor |
| Lourdes Hernández | Music Consultant |
| Toño Cubillo | ADR Recordist |
| Ryan Nowak | Sound Designer |
| Daniel Peña | Sound Editor |
| Yuliya Manolova | Visual Effects Coordinator |
| Agustín Serna G. Lavín | Assistant Editor |
| Adrián Foulkes | Music Producer |
| Alejandro Uribe Holguín | ADR Recordist |
| Adrian Gougov | Dialogue Editor |
| Andy Robinson | Compositor |
| Sandra Migueli | Key Makeup Artist |
| Tatiana Dulcey | Assistant Property Master |
| Garret Lord | First Assistant Accountant |
| Juanma López | Sound Mixer |
| Kris Casavant | Supervising Sound Editor |
| Ivailo Bonev | Concept Artist |
| Juan Pablo Rincón | Casting |
| Diego Garcia | Leadman |
| Dimitar Krustev | Drone Pilot |
| Oscar Felipe Rineda Carvaial | First Assistant Camera |
| Mariana Zubillaga | Location Coordinator |
| Lili Bonil | Key Makeup Artist |
