 | Jim Carrey als Joel Barish |
 | Kate Winslet als Clementine Kruczynski |
 | Kirsten Dunst als Mary Svevo |
 | Mark Ruffalo als Stan Fink |
 | Elijah Wood als Patrick |
 | Tom Wilkinson als Dr. Howard Mierzwiak |
 | Jane Adams als Carrie Eakin |
 | David Cross als Rob Eakin |
 | Deirdre O'Connell als Hollis Mierzwiak |
 | Thomas Jay Ryan als Frank |
 | Ryan Whitney als Young Joel |
 | Lola Daehler als Young Clementine |
 | Debbon Ayer als Joel's Mother |
 | Gerry Robert Byrne als Train Conductor |
 | Brian Price als Young Bully |
 | Josh Flitter als Young Bully |
 | Paulie Litt als Young Bully |
 | Amir Ali Said als Young Bully |
 | Lauren Adler als Rollerblader (uncredited) |
| Michel Gondry | Director |
| Jon Brion | Original Music Composer |
| Ellen Kuras | Director of Photography |
| Anthony Bregman | Producer |
| Steve Golin | Producer |
| Christopher Norr | Camera Operator |
| Charlie Kaufman | Screenplay |
| Charlie Kaufman | Story |
| Michel Gondry | Story |
| Pierre Bismuth | Story |
| Dan Leigh | Production Design |
| Valdís Óskarsdóttir | Editor |
| Jeanne McCarthy | Casting |
| Melissa Toth | Costume Design |
| Ron von Blomberg | Set Decoration |
| Mary Cybulski | Script Supervisor |
| David L. Bushell | Executive Producer |
| Glenn Williamson | Executive Producer |
| Georges Bermann | Executive Producer |
| Charlie Kaufman | Executive Producer |
| John C. Nadeau | Gaffer |
| Philip Stockton | Supervising Sound Editor |
| David Stein | Art Direction |
| Allen Weisinger | Makeup Artist |
| Mark Dornfeld | Visual Effects Supervisor |
| Louis Morin | Visual Effects Supervisor |
| Kam Chan | Foley Editor |
| Marko Costanzo | Foley Artist |
| Eugene Gearty | Sound Re-Recording Mixer |
| Eugene Gearty | Sound Designer |
| George A. Lara | Foley Mixer |
| Marissa Littlefield | ADR Editor |
| Tom Nelson | Sound Mixer |
| Jay Peck | Foley Artist |
| Fred Rosenberg | Dialogue Editor |
| Reilly Steele | Sound Re-Recording Mixer |
| Paul Urmson | Sound Effects Editor |
| Michael Hausman | First Assistant Director |
| Scott Ferguson | Second Assistant Director |
| Peter Thorell | Second Second Assistant Director |
| David L. Bushell | Unit Production Manager |
| Ray Angelic | Assistant Unit Manager |
| Carlos Omar Guerra | First Assistant Camera |
| Braden Belmonte | Second Assistant Camera |
| Peter Agliata | "B" Camera Operator |
| Mark Schmidt | Additional Camera |
| Stanley Fernandez Jr. | First Assistant "B" Camera |
| Christopher Raymond | Second Assistant "B" Camera |
| Angela Bellisio | Camera Loader |
| David Lee | Still Photographer |
| Tommy Louie | Boom Operator |
| Scott P. Murphy | Assistant Art Director |
| Hinju Kim | Assistant Art Director |
| Natalie N. Dorset | Assistant Set Decoration |
| Addy McClelland | Art Department Coordinator |
| Michael Leather | Leadman |
| Ruth DeLeon | On Set Dresser |
| Roman Greller | Set Dresser |
| David Scott Gagnon | Set Dresser |
| John Roche | Set Dresser |
| Brian Buteau | Set Dresser |
| Christian Brockey | Assistant Production Coordinator |
| Francesca Paris | Hairstylist |
| Noriko Watanabe | Makeup Artist |
| Noriko Watanabe | Hairstylist |
| Peter Owen | Wigmaker |
| Kyra Panchenko | Key Makeup Artist |
| Michelle Johnson | Key Hair Stylist |
| Jill Kliber | Assistant Costume Designer |
| Lisa R. Frucht | Wardrobe Supervisor |
| David Page | Costumer |
| Cara Borrelli | Costumer |
| Joseph Quirk | Gaffer |
| Mark Summers | Best Boy Electric |
| Andrea Cronin-Souza | Electrician |
| Paul Daley | Rigging Gaffer |
| Robert M. Andres | Key Grip |
| Chris Skutch | Best Boy Grip |
| Lamont Crawford | Dolly Grip |
| Alison Barton | Grip |
| Mel Cannon | Grip |
| Tony Campenni | Grip |
| John Panuccio | Key Rigging Grip |
| Kevin Ladson | Property Master |
| R. Vincent Smith | Assistant Property Master |
| Morgan Pitts | Props |
| Brian Smyj | Stunt Coordinator |
| Danny Aiello III | Stunts |
| E.J. Evans | Stunts |
| Stephanie Finochio | Stunts |
| Artie Malesci | Stunts |
| Stephen A. Pope | Stunts |
| Bill Anagnos | Stunts |
| John R. Favre | Stunts |
| Cort Hessler | Stunts |
| Peewee Piemonte | Stunts |
| Michael Russo | Stunts |
| Frank Kern | Foley Editor |
| Steven Visscher | Foley Editor |
| Chris Fielder | Assistant Sound Editor |
| Larry Wineland | Assistant Sound Editor |
| Michele Ferrone | Visual Effects Producer |
| Blythe Cappello | Casting |
| Natasha Cuba | Casting Associate |
| John Srednicki | Casting Assistant |
| Sage Lehman | Casting Assistant |
| Linda R. Chen | Casting Assistant |
| Grant Wilfley | Extras Casting |
| Kristian Sorge | Extras Casting Assistant |
| Nick Miller | Construction Coordinator |
| Brent Haywood | Construction Coordinator |
| Mark Bero | Special Effects |
| Drew Jiritano | Special Effects Coordinator |
| Thomas Viviano | Special Effects |
