 | Hugh Grant als Dr. Guy Luthan |
 | Gene Hackman als Dr. Lawrence Myrick |
 | Sarah Jessica Parker als Jodie Trammel |
 | David Morse als Frank Hare |
 | Bill Nunn als Burke |
 | Paul Guilfoyle als Dr. Jeffrey Manko |
 | Debra Monk als Dr. Judith Gruszynski |
 | John Toles-Bey als Bobby |
 | Peter Appel als Det. Stone |
 | Shaun Austin-Olsen als Claude Minkins |
 | André De Shields als Teddy Dolson |
 | J.K. Simmons als Dr. Mingus |
| Diana Zimmer als Helen |
 | Nancy Beatty als Ruth Myrick |
 | Gerry Becker als Dr. Gene Spitelli |
 | Gene Ruffini als Izzy |
 | Bill MacDonald als Det. Stone's Partner |
 | Garnet Harding als E.R. Doctor |
 | Simon Reynolds als E.R. Doctor |
| Derwin Jordan als E.R. Doctor |
 | Tara Rosling als E.R. Doctor |
 | Martin Roach als E.R. Doctor |
| Bernard Browne als E.R. Doctor |
 | Sanjay Talwar als E.R. Doctor |
| Christina Collins als E.R. Nurse |
 | Arlene Duncan als E.R. Nurse |
| Cheryl Swarts als E.R. Nurse |
 | Peter Maloney als Mr. Randall |
 | Johnie Chase als Cop |
 | Noam Jenkins als Criminal |
 | Larissa Laskin als Myrick's Daughter |
| Phallon Carpino als Granddaughter |
| Ross Petty als Dr. Garlock |
| Todd Stewart als Shelter Supervisor |
 | Lawrence Arancio als Medical Examiner |
| Vincent Marino als Janitor |
 | Marcia DeBonis als Pam |
 | John Ventimiglia als Det. Manning |
 | John Heffernan als Cartman |
 | Raynor Scheine als Half-Mole |
 | John Trudell als Tony |
 | Nelson Vasquez als Skicap |
 | Vincent Laresca als Patches |
 | Denis Akiyama als Prof. Asakura |
 | Kim Roberts als Home Nurse |
 | Gerry Quigley als Party Guest |
 | Teresa Yenque als Neighbor |
| Chris Edwards als Uniformed Cop |
 | David Eisner als Guy's Lawyer |
| Dana Stevens als Prosecutor |
 | Michael J. Reynolds als Judge |
 | David Cronenberg als Hospital Lawyer |
 | Jackie Richardson als Triphase Nurse |
| Marium Carvell als Triphase Nurse |
| Marilyn McDonald als Mole Lady |
 | Desi Moreno als Toll Collector (uncredited) |
| Danny Elfman | Original Music Composer |
| Rick Shaine | Editor |
| Michael Apted | Director |
| Tony Gilroy | Screenplay |
| John Bailey | Director of Photography |
| Elizabeth Hurley | Producer |
| Ray Fisher | Leadman |
| Linda Lowy | Casting |
| John Brace | Casting |
| Susan Lyall | Costume Design |
| Doug Kraner | Production Design |
| Chris Brigham | Co-Producer |
| Andrew Scheinman | Executive Producer |
| Michael Palmer | Novel |
| Chris Brigham | Unit Production Manager |
| Marilyn Stonehouse | Unit Production Manager |
| David Webb | First Assistant Director |
| Bruno Bryniarski | Second Assistant Director |
| Michele Rakich | Second Second Assistant Director |
| Tony Gittelson | First Assistant Director |
| Amy Lauritsen | Second Assistant Director |
| Kate Eisemann | Second Second Assistant Director |
| Denise Pinckley | Assistant Unit Manager |
| Jeanney Kim | Associate Producer |
| Tia Nolan | Assistant Editor |
| Kay Chapin | Script Supervisor |
| Paul D. Austerberry | Art Direction |
| Gordon Sim | Set Decoration |
| Angelo Colavecchia | Camera Operator |
| Michael Stone | Camera Operator |
| Michael Stone | Steadicam Operator |
| Angelo Colavecchia | Steadicam Operator |
| Bruce Carwardine | Sound Mixer |
| Tom Nelson | Sound Mixer |
| Michael Kavanagh | Special Effects Supervisor |
| Jery Hewitt | Stunt Coordinator |
| Donald Mowat | Key Makeup Artist |
| Donald Mowat | Makeup Artist |
| David Fields | Hairstylist |
| Larry Mann | Supervising Sound Editor |
| Paul Massey | Sound Re-Recording Mixer |
| Doug Hemphill | Sound Re-Recording Mixer |
| Mary-Lou Green-Benvenuti | Hairstylist |
| Andrew M. Stearn | Set Designer |
| Thomas Carnegie | First Assistant Art Direction |
| Mun Ying Kwun | First Assistant Art Direction |
| Ken Watkins | First Assistant Art Direction |
| KEi | Second Assistant Art Director |
| Keith Sly | On Set Dresser |
| Michael Vanderteems | On Set Dresser |
| Michael Clancy | Assistant Costume Designer |
| Kathleen Meade | Wardrobe Supervisor |
| Ron Scott | Hairstylist |
| Carol Marinoff | Assistant Hairstylist |
| Carol Davidson | Assistant Makeup Artist |
| Rick Forsayeth | Stunt Coordinator |
| Tom Warren | Art Direction |
| Alyssa Winter | Set Decoration |
| Matt Vogel | Special Effects |
| David Stein | Assistant Art Director |
| Jessica Lanier | Assistant Set Decoration |
| Jane E. Williams | Wardrobe Supervisor |
| Frank L. Fleming | Assistant Costume Designer |
| Jill E. Anderson | Wardrobe Supervisor |
| Daniel K. Grosso | Set Dresser |
| Rick Nelson | Set Dresser |
| Greco | Set Dresser |
| William A. Farley | Key Hair Stylist |
| Leslie Fuller | Assistant Makeup Artist |
| Sean Garnhart | Sound Effects Editor |
| Craig Berkey | Sound Effects Editor |
| John Edwards-Younger | Sound Effects Editor |
| Cindy Marty | Sound Effects Editor |
| David Lewis Yewdall | Sound Effects Editor |
| Jerelyn J. Harding | Supervising ADR Editor |
| Paul Apted | Assistant Sound Editor |
| David Burk | Assistant Sound Editor |
| Aisling O'Brien | Visual Effects Producer |
| Rob Hodgson | Visual Effects Supervisor |
| Chris Watts | Visual Effects Supervisor |
| Jennifer Lamb | Stunts |
| Susan Dawes | Assistant Sound Editor |
| Mickey Giacomazzi | Stunts |
