 | Miles Teller als Reed Richards / Mr. Fantastic |
 | Michael B. Jordan als Johnny Storm / The Human Torch |
 | Kate Mara als Sue Storm / Invisible Woman |
 | Jamie Bell als Ben Grimm / The Thing |
 | Toby Kebbell als Doctor Victor von Doom |
 | Reg E. Cathey als Dr. Franklin Storm |
 | Tim Blake Nelson als Harvey Elder |
 | Joshua Montes als Quarterback Speech School Kid |
 | Dan Castellaneta als Mr. Kenny |
 | Owen Judge als Young Reed |
 | Kylen Davis als Teasing School Kid |
 | Evan Hannemann als Young Ben |
 | Chet Hanks als Jimmy Grimm |
 | Mary-Pat Green als Mrs. Grimm |
 | Tim Heidecker als Mr. Richards |
 | Mary Rachel Dudley als Mrs. Richards |
 | Wayne Pére als Science Fair Judge #1 |
 | Rhonda Johnson Dents als Science Fair Judge #2 |
 | Don Yesso als Pentagon General |
| Jodi Lyn Brockton als Lawyer |
 | Lance E. Nichols als DC Senior Official (Area 57) |
 | Dina Morrone als Emergency Announcer (Area 57) |
 | Ravi Naidu als Ben Scientist #1 (uncredited) |
 | Aaron V. Williamson als Navy Seal (uncredited) |
| Barney Lanning als Science Fair Plane Kid |
 | Dennis Thomas IV als Baxter Security Guard |
 | Abhi Trivedi als Baxter Employee |
 | Benjamin Papac als Baxter Student |
 | Jim Gleason als Board Member |
| Gabe Begneaud als Trash Talk Car Driver |
| Anna R. Parsons als Girl Classmate |
| Brian Stapf als Reed's Guard (Area 57) |
 | Ben VanderMey als Soldier (Area 57) |
| Elvin Presley als Drag Race Official |
 | Brittney Alger als Street Race Girl |
| J.T. Rowland als Monkey Test Lab Technician |
 | Gretchen Koerner als Reed's Scientist (Area 57) |
 | Hunter Burke als Reed's Scientist (Area 57) |
 | Han Soto als Reed's Doctor (Area 57) |
 | Michael Harrity als Military Interrogator (Area 57) |
| Melissa McCurley als Sue's Doctor (Area 57) |
 | Jane Rumbaua als Johnny's Doctor (Area 57) |
 | Anthony Reynolds als Airplane Military Official (Area 57) |
 | Spence Maughon als Johnny's Technician (Area 57) |
 | Deneen Tyler als DC Military Official (Area 57) |
 | Marco St. John als DC Military Official (Area 57) |
 | Shauna Rappold als Computer Military Tech (Area 57) |
 | Fernando Rivera als Disguised Reed |
| Juan Corrigan als Barber Shop Owner |
 | Jaylen Moore als Tarmac Guard |
| Tre Styles als Tarmac Guard |
 | Adam Fristoe als Quantum Gate Scientist (Area 57) |
| Jackson Pyle als Government Caretaker |
 | Tim Bell als Local Cop (uncredited) |
 | Nicolas Bosc als Rebel (uncredited) |
| Christopher Heskey als Delta Force Soldier #2 (uncredited) |
| Nathaniel Holt als Military Tech (uncredited) |
| Lisa Ann Smith als NYC Passerby (uncredited) |
 | Catherine Kresge als Lab Tech (uncredited) |
| Samantha Hopkins als Sibling (uncredited) |
 | David Jensen als War Room Soldier (uncredited) |
 | Michael Papajohn als Tank Commander (uncredited) |
| Robert Kulzer | Producer |
| Ronna Kress | Casting |
| Stephen E. Rivkin | Director |
| Stephen E. Rivkin | Editor |
| Matthew Vaughn | Producer |
| Philip Glass | Original Music Composer |
| Marco Beltrami | Original Music Composer |
| Victor J. Zolfo | Set Decoration |
| Stan Lee | Executive Producer |
| Stan Lee | Characters |
| Michael Papajohn | Stunts |
| Paul Hughen | Second Unit Director of Photography |
| Simon Kinberg | Screenplay |
| Simon Kinberg | Director |
| Simon Kinberg | Producer |
| George L. Little | Costume Design |
| Laurel Van Dyke | Key Hair Stylist |
| Brian Smrz | Second Unit Director |
| Jack Kirby | Characters |
| Jeffrey J. Dashnaw | Stunt Coordinator |
| Richard Bronskill | Orchestrator |
| Daniel J. Lester | Assistant Costume Designer |
| Joe Bucaro III | Stunts |
| Warren Hendriks | Sound Designer |
| Paul Massey | Sound Re-Recording Mixer |
| Tierre Turner | Stunts |
| Chris Seagers | Production Design |
| Curt Sobel | Music Editor |
| Douglas Cumming | Art Direction |
| Kenneth Nakada | Visual Effects Supervisor |
| Mark Millar | Creative Consultant |
| Al Cerullo | Stunts |
| Charlie Picerni | Stunts |
| Francisco X. Pérez | Makeup Department Head |
| Matthew Jensen | Director of Photography |
| Clyde E. Bryan | First Assistant Camera |
| Gregory Goodman | Producer |
| Sean Paul Braud | Stunts |
| Brian Simpson | Stunts |
| Zack Duhame | Stunts |
| Tim Trella | Stunts |
| Helena Barrett | Stunts |
| Helena Barrett | Stunt Double |
| Jim Henry | Stunts |
| Jay Amor | Stunts |
| Jeff Galpin | Stunts |
| Andrea von Foerster | Music Supervisor |
| Hutch Parker | Producer |
| Josh Trank | Screenplay |
| Josh Trank | Director |
| Miguel López-Castillo | Art Direction |
| Elliot Greenberg | Editor |
| Mandy Kowalski | Stunts |
| Mandy Kowalski | Stunt Double |
| Thirl Haston | Stunts |
| Jeremy Slater | Screenplay |
| Elena Sanchez | Stunts |
| Tristan Paris Bourne | Art Direction |
| Brian Brown | Stunts |
| Matt Leonard | Stunts |
| David Schultz | Stunts |
| Tim J. Smith | Stunts |
| Clay Donahue Fontenot | Stunts |
| Dennis Liddiard | Makeup Artist |
| Mark Fisher | Stunts |
| Robert Q. Mathews | Costume Supervisor |
| Tom Frohling | Supervising Art Director |
| Brian Kane | Art Direction |
| Elizabeth Coulon | Casting |
| Dan O'Connell | Foley Artist |
| Craig Henighan | Sound Designer |
| Craig Henighan | Supervising Sound Editor |
| Dug Rotstein | Script Supervisor |
| Joel Thingvall | Researcher |
| Shayna Brown | Sound Re-Recording Mixer |
| Carol Kiefer | Art Department Coordinator |
| Jason Ellson | Steadicam Operator |
| Clint Wallace | Art Direction |
| Andrew M. Siegel | Property Master |
| John T. Cucci | Foley Artist |
| Anthony Ortiz | Boom Operator |
| Marie-Cecile Dahan | Visual Effects Producer |
| François Dumoulin | Visual Effects Supervisor |
| Tricia Yoo | Set Costumer |
| Bruce Lomet | Digital Intermediate |
| Phil Neilson | Stunts |
| Will Files | Sound Re-Recording Mixer |
| Steve M. Davison | Stunts |
| Brian Machleit | Stunt Coordinator |
| Ben Rothstein | Still Photographer |
| Jim Brookshire | Supervising ADR Editor |
| Benjamin Beardwood | Sound Editor |
| Hans Bjerno | Helicopter Camera |
| John Berri | Visual Effects Editor |
| Julia Neighly | Visual Effects Producer |
| Rob King | Stunts |
| Patrick B. O'Brien | Camera Operator |
| Matt Tassone | First Assistant Editor |
| Cari Thomas | Visual Effects Producer |
| Wayne Lemmer | Sound Designer |
| Frank Torres | Stunts |
| James Meikle | Visual Effects Editor |
| David B. Nowell | Helicopter Camera |
| Kevin Scott Mack | Visual Effects Supervisor |
| Joseph V. Cicio | Camera Operator |
| Brian Heller | Helicopter Camera |
| Dan Riffel | Gaffer |
| Adriane Bennett | Set Costumer |
| Carla S. Nemec | Art Department Coordinator |
| Regis Harrington | Stunts |
| Daniel C. Gold | Camera Operator |
| Leon Woud | Animation Director |
| Fabiano Petroni | Animation Director |
| Sean Andrew Faden | Visual Effects Supervisor |
| Brady Romberg | Stunts |
| Jonathan Taylor | Additional Photography |
| Brooks Robinson | Steadicam Operator |
| Tom Cummins | Set Costumer |
| Colette Slattery | Key Hair Stylist |
| Michael Applebaum | Camera Operator |
| Dale DeStefani | Construction Coordinator |
| Joseph Arena | Steadicam Operator |
| Kimberley Spiteri | Hair Department Head |
| Adam Hart | Stunts |
| Ashley Nicole Hudson | Stunts |
| Kevin Andrew Smith | Visual Effects Supervisor |
| Nico Woulard | Stunts |
| Jason Chu | Stunts |
| J.J. Dashnaw | Stunts |
| Michael Jamorski | Stunts |
| Hannah d'Angerio | Casting Associate |
| Nicolas Bosc | Stunts |
| Jon Kull | Orchestrator |
| John Bernecker | Stunts |
| Larry Zanoff | Armorer |
| Marlie Arnold | Researcher |
| Zachary Berger | Conceptual Design |
| Rossano Galante | Orchestrator |
| Russell Cannon | Armorer |
| Lisa Rocco | Makeup Artist |
| Arthur Kirk Martin | Carpenter |
| Justine Baker | ADR Recordist |
| Mikaël Damant-Sirois | CG Supervisor |
| Jérome Escobar | CG Supervisor |
| Owen Jones | CG Supervisor |
| Sean Noel Walker | CG Supervisor |
| Jimmy E. Jensen | First Assistant Camera |
| Ray Milazzo | First Assistant Camera |
| Andre Green | Rigging Gaffer |
| Oleg Jiliba | VFX Editor |
| Michel Raad | VFX Editor |
| Guillaume Poulin | VFX Editor |
| Patrick J. Smith | First Assistant Editor |
| Eli Jarra | Visual Effects Supervisor |
| Blaine Lougheed | Visual Effects Supervisor |
| Patrick Ledda | Visual Effects Supervisor |
| Jenna Barratt | Visual Effects Editor |
| Christopher Collis | Visual Effects Editor |
| William Day | Visual Effects Editor |
| Michael Endoso | Stunts |
| Erik Schultz | Stunts |
| Guy Fernandez | Stunts |
| Kevin Abercrombie | Stunts |
| Frank Reina | Production Office Assistant |
| Eddie J. Fernandez Jr. | Stunts |
| Malosi Leonard | Stunts |
| Heidi Pascoe | Stunts |
| Heidi Pascoe | Stunt Double |
| Matt J. Thompson | Stunts |
| Richard Epper | Stunts |
| Ben Skorstad | Stunts |
| Chad Dashnaw | Stunts |
| Brian Philpot | Stunts |
| Arturo Dickey | Stunts |
| Chris Ekstrom | Stunts |
| Ryan Ryusaki | Stunts |
| Adam Horwitz | Stunts |
| Rick Newsome | Storyboard Designer |
| Cliff McLaughlin | Stunts |
| Michael Hansen | Stunts |
| Jordan Warrack | Stunts |
| Walter Garcia | Stunts |
| Sean Taylor | Stunts |
| Michael Ortiz | Stunts |
| Liam Day | Stunts |
| Chris J. Fanguy | Stunts |
| Brennan Walstrom | Stunts |
| Ashley Wilks | Stunts |
| Ryan Staats | Stunts |
| Aaron Walters | Stunts |
| Brandon Cornell | Stunts |
| Nathan Alan Thomas | Stunts |
| Johnny Hoffman | Stunts |
