 | Ioan Gruffudd als Reed Richards / Mr. Fantastic |
 | Jessica Alba als Sue Richards / Invisible Woman |
 | Chris Evans als Johnny Storm / Human Torch |
 | Michael Chiklis als Ben Grimm / The Thing |
 | Julian McMahon als Victor von Doom / Doctor Doom |
 | Kerry Washington als Alicia Masters |
 | Andre Braugher als General Hager |
 | Laurence Fishburne als Norrin Radd / Silver Surfer (voice) |
 | Doug Jones als Norrin Radd / Silver Surfer |
 | Beau Garrett als Frankie Raye |
 | Brian Posehn als Priest |
 | Zach Grenier als James Sherman / Rafke |
 | Kenneth Welsh als Dr. Jeff Wagner |
 | Kevin McNulty als Baxter Building Doorman |
 | Andy Stahl als Tailor |
 | Debbie Timuss als Hot Party Girl #1 |
 | Moneca Delain als Hot Party Girl #2 |
 | Crystal Lowe als Hot Party Girl #3 |
| Vanessa Lachey als Johnny's Wedding Date |
 | Stan Lee als Stan Lee - Rejected Wedding Guest |
 | Gonzalo Menendez als Lieutenant |
| Giuliana Rancic als Entertainment Reporter |
| Lauren Sánchez als Fox News Reporter |
 | Patricia Harras als Fan Four Receptionist |
 | Fareed Abdelhak als Egyptian Tour Guide |
| Michael McCusker | Editor |
| Michael McCusker | Additional Editing |
| Bernd Eichinger | Producer |
| Ralph Winter | Producer |
| William Hoy | Editor |
| Heike Brandstatter | Casting |
| Coreen Mayrs | Casting |
| Stan Lee | Executive Producer |
| Stan Lee | Characters |
| Avi Arad | Producer |
| Kevin Feige | Executive Producer |
| Mary E. Vogt | Costume Design |
| John Ottman | Original Music Composer |
| Chris Columbus | Executive Producer |
| Mark Radcliffe | Executive Producer |
| Kirk M. Petruccelli | Production Design |
| Daniel T. Dorrance | Supervising Art Director |
| Michael Barnathan | Executive Producer |
| Jack Kirby | Characters |
| Tim Story | Director |
| Don Payne | Screenplay |
| Larry Blanford | Director of Photography |
| Elizabeth Wilcox | Set Decoration |
| Peter S. Elliot | Editor |
| Caitlin McKenna-Wilkinson | ADR Voice Casting |
| Mark Frost | Screenplay |
| Mark Frost | Story |
| Ross T. Fanger | Co-Producer |
| John Turman | Story |
| Sandi Tanaka | Art Direction |
| Susan Lambie | Script Supervisor |
| Lee Cleary | Co-Producer |
| Stewart Bethune | Associate Producer |
| Allison Calleri | Associate Producer |
| Joe Doserro | Stunts |
