 | Owen Wilson als Kyle |
 | Ed Helms als Peter |
 | J.K. Simmons als Ronald Hunt |
 | Katt Williams als Hitchhiker |
 | Terry Bradshaw als Terry Bradshaw |
 | Ving Rhames als Rod Hamilton |
 | Christopher Walken als Dr. Tinkler |
 | Glenn Close als Helen Baxter |
 | Katie Aselton als Sarah |
 | Retta als Annie |
 | Harry Shearer als Gene |
 | June Squibb als Mrs. Hunt |
 | Ali Wong als Ali |
 | Robert Jon Mello als Mr. Jensen |
 | Zachary Haven als Ethan |
 | Mary Grill als Katherine |
| Ann McKenzie als Sheila |
 | Jessica Gomes als Kaylani |
 | Sarah Skeist als Pretty Flight Attendant |
 | Debra Stipe als Karen Bradshaw |
 | Robert Pralgo als Ferrari Owner |
| Niki Davis als Ferrari Owner's Wife |
 | Donna DuPlantier als ER Doctor |
 | Robert Walker Branchaud als Officer #1 |
| B'nard Lewis als Officer #2 |
 | Andrew Wilson als Hotel Desk Clerk |
 | Ryan Cartwright als Liam |
 | Ryan Gaul als Sean |
 | Taylor Treadwell als Kelly |
 | Jack McGee als Kevin O'Callaghan |
 | Jim France als Father McManus |
 | Ivan Mallon als Young Peter (uncredited) |
 | Annie Starke als Young Helen (uncredited) |
| Lawrence Sher | Director |
| Justin Malen | Screenplay |
| Jeanette Scott | Set Decoration |
| Blair Foster | Casting Associate |
| Broderick Johnson | Producer |
| Dana E. Glauberman | Editor |
| Alex Plapinger | Co-Producer |
| Rob Simonsen | Original Music Composer |
| Jeremy Woolsey | Art Direction |
| Patty Harrigan | Production Coordinator |
| Chris Fenton | Executive Producer |
| Tom Pollock | Executive Producer |
| John Lindley | Director of Photography |
| Ben Schor | Supervising Music Editor |
| Carl Rogers | Co-Producer |
| Kristen Jenkins | Set Designer |
| Deanna Brigidi | Casting Associate |
| Ryan Schaetzle | Location Manager |
| Gail Hunter | Script Supervisor |
| Timothy M. Bourne | Executive Producer |
| Jennifer Radzikowski | Location Manager |
| Nan Morales | Line Producer |
| Lenzi Sealy | Location Scout |
| Heath M. Howard | Production Coordinator |
| Julie Donovan | Associate Producer |
| Scott Parish | Executive Producer |
| Ivan Reitman | Producer |
| John Papsidera | Casting |
| Stephen H. Carter | Production Design |
| Dana Belcastro | Co-Producer |
| Chris Cowles | Executive Producer |
| Andrew A. Kosove | Producer |
| Stacie McKinnon | Art Department Coordinator |
| Emily Bohbrink | Casting Assistant |
| Ali Bell | Producer |
| Nathan Krochmal | Set Designer |
| Brad Arensman | Post Production Supervisor |
| Andrew C. Keeter | Production Supervisor |
| George Drakoulias | Music Editor |
| Christopher Gray | Casting |
| Denise Gallo | Stunt Driver |
| Julie Weiss | Costume Designer |
| George Drakoulias | Music Supervisor |
| Timothy M. Bourne | Unit Production Manager |
| Richard L. Fox | First Assistant Director |
| Meaghan F. McLaughlin | Second Assistant Director |
