 | Johnny Depp als Raoul Duke |
 | Benicio del Toro als Dr. Gonzo |
 | Tobey Maguire als Hitchhiker |
 | Michael Lee Gogin als Uniformed Dwarf |
 | Larry Cedar als Car Rental Agent - Los Angeles |
 | Brian Le Baron als Parking Attendant |
 | Katherine Helmond als Desk Clerk at Mint Hotel |
 | Michael Warwick als Bell Boy |
 | Craig Bierko als Lacerda |
 | Tyde Kierney als Reporter |
 | Mark Harmon als Magazine Reporter |
 | Tim Thomerson als Hoodlum |
 | Richard Riehle als Dune Buggy Driver |
| Ransom Gates als Dune Buggy Passenger |
| Frank Romano als Dune Buggy Passenger |
| Gil Boccaccio als Desert Room Doorman |
| Gary Bruno als Desert Room Doorman |
 | Richard Portnow als Wine Colored Tuxedo |
 | Debbie Reynolds als Debbie Reynolds (voice) |
 | Steve Schirripa als Goon |
 | Verne Troyer als Wee Waiter |
| Will Blount als The Black Guy |
| Ben Yeagar als Clown Barker |
 | Penn Jillette als Carnie Talker |
 | Christopher Callen als Bazooko Circus Waitress |
 | Cameron Diaz als Blonde TV Reporter |
 | Benjamin A. Van Der Veen als TV Crew Man |
 | Lyle Lovett als Road Person |
 | Flea als Musician |
| Alex Craig Mann als Stockbroker |
 | Gregory Itzin als Mint Hotel Clerk |
 | Gary Busey als Highway Patrolman |
 | Troy Evans als Police Chief |
| Gale Baker als Police Chief's Wife |
 | Christopher Meloni als Clerk at Flamingo Hotel |
 | Christina Ricci als Lucy |
| Chris Hendrie als Executive Director |
 | Larry Brandenburg als Cop in Car |
 | Michael Jeter als Ron Bumquist |
| Donald Morrow als Film Narrator (voice) |
 | Harry Dean Stanton als Judge |
 | Jenette Goldstein als Maid |
 | Stephen Bridgewater als Human Cannonball |
 | Buck Holland als Shopper |
| Mary Gillis als Shopper |
 | Jennifer Elise Cox als Shopper |
| Robert Allen als Car Rental Agent - Los Angeles |
| David Brisbin als Man in Car |
 | Ellen Barkin als Waitress at North Star Cafe |
| James O'Sullivan als TV Newsman |
| Milt Tarver als TV Newsman |
| Kathryn Alexander als Lizard Performer |
| Mia Babalis als Lizard Performer |
| Kristin Draudt als Lizard Performer |
 | Kim Flowers als Lizard Performer |
| Trudi Forristal als Lizard Performer |
| Nan Friedman als Lizard Performer |
| Judith Lieff als Lizard Performer |
 | Tane McClure als Lizard Performer |
| Diana Mehoudar als Lizard Performer |
| Geoffrey Nimmer als Lizard Performer |
| Marlene Bologna als Trapeze Artist |
| Chobi Gyorgy als Trapeze Artist |
| Karen Price als Trapeze Artist |
 | Lisa Hoyle als Trapeze Artist |
 | Joseph S. Griffo als Trapeze Artist |
 | Laraine Newman als Frog-Eyed Woman (uncredited) |
 | Hunter S. Thompson als Other Duke in Matrix Flashback (uncredited) |
| Lesley Walker | Editor |
| Nancy Haigh | Set Decoration |
| Patrick Cassavetti | Producer |
| Terry Gilliam | Director |
| Margery Simkin | Casting |
| Laila Nabulsi | Producer |
| Julie Weiss | Costume Design |
| Stephen Nemeth | Producer |
| Nicola Pecorini | Director of Photography |
| Chris Gorak | Art Direction |
| Alex McDowell | Production Design |
| Terry Gilliam | Screenplay |
| Elliot Lewis Rosenblatt | Co-Producer |
| Ronald Day | Painter |
| JoAnn Fregalette Jansen | Choreographer |
| Lynn Christopher | Set Designer |
| Glen Hanz | Sculptor |
| Mark Weissenfluh | Leadman |
| Mark Blumenthal | Standby Painter |
| Frank Perl | Camera Operator |
| Alex Cox | Screenplay |
| Tony Grisoni | Screenplay |
| Tod Davies | Screenplay |
| John Jergens | Associate Producer |
| Harold Bronson | Executive Producer |
| Richard Foos | Executive Producer |
| Ray Cooper | Original Music Composer |
| Rob Bottin | Makeup Effects |
| Bridget Cook | Hairstylist |
| Olga Ishkhanova | Seamstress |
| Bill Fletcher | Wigmaker |
| Maureen Kropf | Scenic Artist |
| Michael Singer | Unit Publicist |
| Deborah Ricketts | Researcher |
| Randy Benjamin | Picture Car Coordinator |
| Peter Pennell | Supervising Sound Editor |
| Michael Cooper | Visual Effects Coordinator |
| Tani Kunitake | Production Illustrator |
| Michael Solinger | Post Production Supervisor |
| Matt Langenbach | Stand In |
| James Babineaux | Best Boy Electric |
| Ray Svedin | Special Effects Supervisor |
| Eden Clark Coblenz | Costume Supervisor |
| Jay Meagher | Production Sound Mixer |
| Kelly Joe Dugan | Stunts |
| Linda S. Cormany | Set Costumer |
| Pedro Amaya | Driver |
| Roanne Moore | Post Production Assistant |
| Łukasz Bielan | First Assistant Camera |
| Noon Orsatti | Stunt Coordinator |
| James Lowder | Transportation Coordinator |
| Pearl A. Lucero | Production Coordinator |
| Peter Mountain | Still Photographer |
| Karon May | Script Supervisor |
| Randy Smith | Boom Operator |
| Andrea Carter | Art Department Coordinator |
| Frank McEldowney | Greensman |
| Nicola Pecorini | Steadicam Operator |
| David Rees | Color Timer |
| Dan Pemberton | Construction Coordinator |
| Kent Houston | Visual Effects Supervisor |
| Kimberly Adams | Assistant Costume Designer |
| Gloria M. Fujita | Set Medic |
| Jimmy Bennett | Set Production Assistant |
| Reynaldo Barrera | Electrician |
| Molly Allen | Location Manager |
| Dianne Chadwick | Art Department Assistant |
| Gary Gingold | Craft Service |
| Steve Galich | Special Effects Coordinator |
| Ian Kelly | Video Assist Operator |
| Dominic Lester | Sound Re-Recording Mixer |
| Tom Lifsey | Construction Foreman |
| Pat Stubbs | Transportation Co-Captain |
| Mark Indig | Unit Production Manager |
| Earl F. Betts | Propmaker |
| Christopher Lyons | Gaffer |
| Kevin Lane | Music Editor |
| Martin Cantwell | Assistant Sound Editor |
| Peter Chrimes | Key Grip |
| Cheryl Ann Nick | Key Makeup Artist |
| Paige Augustine | Set Dresser |
| Nancy Restuccia | Assistant Production Coordinator |
| Christina Fong | Second Assistant Director |
| Lila Byall | Camera Loader |
| Carlos M. Gallardo | Dolly Grip |
| Caroline Dale | Musician |
| Joe Gallagher | ADR Editor |
| Michael Mick Armstrong | Grip |
| Rebeka L. Roberts | Ager/Dyer |
| Carmen Cuba | Casting Assistant |
| Stephen Bridgewater | ADR Supervisor |
| John Linsmeier | Key Costumer |
| Philip A. Patterson | First Assistant Director |
| David Acord | Utility Sound |
| Lisa Rocco | Makeup Artist |
| Bob Risk | Foley Editor |
| J.R. Westen | ADR Mixer |
| Sav Akyüz | Intern |
| Bruce Logan | Second Unit Director |
| Amy Gilliam | Wardrobe Assistant |
| Jeremy Hume | Assistant Editor |
| P. Scott Bailey | Swing |
| Jimmy Ortega | Stunt Double |
| Keli Craig | Production Assistant |
| Martin Charles | Graphic Designer |
| Sonja Rom | Camera Production Assistant |
| Susan Giordano | First Assistant Accountant |
| Serena Baker | Location Assistant |
| Seth Edelstein | Second Second Assistant Director |
| Bryan Birge | Costumer |
| R. Scott Poole | Assistant Location Manager |
| Kristen Felan | Payroll Accountant |
| Vidal Cohen | Best Boy Grip |
| Warren Feldman | Second Assistant Camera |
| Jenni Wieland | Second Assistant Accountant |
| Joe Barden | Special Effects Assistant |
| Steve Itano | First Assistant "A" Camera |
| Jose Gonzales | Catering |
| Alisa Moeller | Assistant Production Coordinator |
| Paul Carr | ADR Recordist |
| Alan Paley | Dialogue Editor |
| Will Blount | Property Master |
| Ernie F. Orsatti | Stunts |
| Hunter S. Thompson | Novel |
