 | Matilda Lawler als Flora Buckman |
 | Alyson Hannigan als Phyllis Buckman |
 | Ben Schwartz als George Buckman |
 | Danny Pudi als Miller |
 | Benjamin Evan Ainsworth als William Spiver |
 | Kate Micucci als Rita |
 | Nancy Robertson als Tootie |
 | Christine Lee als Journalist |
 | Darien Martin als Incandesto |
 | Carolyn Yonge als Technician |
 | Kyle Strauts als Shobo |
 | Craig Haas als Meter Man |
 | Malaika Jackson als Animal Control Tech |
 | Arkie Kandola als Binders Keepers Employee |
 | Nicholas Dohy als Squirrel Man (uncredited) |
 | Bobby Moynihan als Stanlee |
 | Janeane Garofalo als Marissa |
 | Anna Deavere Smith als Dr. Meescham |
| Kate DiCamillo | Novel |
| Lena Khan | Director |
| Gil Netter | Producer |
| Katterli Frauenfelder | Executive Producer |
| Brad Copeland | Screenplay |
| Andrew Dunn | Director of Photography |
| Michael Fitzgerald | Production Design |
| Jamie Gross | Editor |
| Mona May | Costume Design |
| Jake Monaco | Original Music Composer |
| Zachary Dawes | Executive Music Producer |
| Emily Schweber | Casting Director |
| Daryl Sawchuk | Visual Effects Supervisor |
| David Feinsilber | Visual Effects Producer |
| Michael Diner | Art Direction |
| Gwendolyn Margetson | Art Direction |
| Andrew Li | Set Designer |
| Zoe Jirik | Set Decoration |
| Connie Parker | Makeup Department Head |
| Sanna Seppanen | Hair Department Head |
| Mark Noda | Sound Mixer |
| Leslie Rodier | Post Production Supervisor |
| Matt Todaro | VFX Editor |
| Aaron Glascock | Sound Designer |
| Aaron Glascock | Sound Supervisor |
| Tony Lazarowich | Special Effects Coordinator |
| Jon Mooney | Supervising Music Editor |
| Nicolas Chevallier | VFX Supervisor |
| Massimo Meo | Visual Effects Producer |
| Thiago Lima Martins | Animation Supervisor |
| Laurent Laban | Animation Supervisor |
| Therese Skundberg Fidje | VFX Editor |
| Bryan Godwin | VFX Supervisor |
| Tyler Marino | Visual Effects Producer |
| William Barkus | VFX Supervisor |
| Peter Steffan | VFX Artist |
| Joanna Mireau | Assistant Makeup Artist |
| Cassandra Ebner | Stunts |
| Owen Walstrom | Stunt Coordinator |
